Indonesian Journal of Tropical and Infectious Disease
Vol 5, No 2 (2014)

COLOSTRUM-COLLAGEN-HYDROXYAPATITE COMPOSITE, AN EXCELLENT CANDIDATE BIOMATERIAL FOR BONE REPAIR AND BONE INFECTION MANAGEMENT

Setiawan, Dio Nurdin ( Bachelor of Biomedical Engineering Study Program, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia )
Anwar, Mirzaq Hussein ( Bachelor of Biomedical Engineering Study Program, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia )
Putri, Kholifatul Wanda ( Bachelor of Information System Study Program, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia )
Fiddarain, Nilna Faizah ( Bachelor of Pharmacy Study Program, Faculty of Pharmasy, Universitas Airlangga, Surabaya, Indonesia )
Widiyanti, Prihartini ( Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia Biomedical Engineering Study Program, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia )
Purnobasuki, Heri ( Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia )



Article Info

Publish Date
06 Jul 2015

Abstract

In the case of bone fracture or defect after surgery, which is common in patients with bone cancer (osteosarcoma), it takes a long time for closure and it may cause an infection problem. The use of collagen-hydroxyapatite composite with a blend of colostrum as a scaffold is aimed to accelerate the process of osteoblast growth, inhibite the emergence of infections, and act as bone tissue repair material. The method used was the hydrogel formation process and freeze dry process to remove the solvent and to form pores. The composition of scaffold composite manufactured was 15% collagen, 75% hydroxyapatite and 10% colostrum. Combination of scaffold collagen-hydroxyapatite-colostrum has quite reliable properties because SEM test showed that scaffold could bind to both and could bind to both and could form sufficient pores to provide enough place for bone cells (osteoblats) to grow. The results of MTT assay revealed percentage of above 60%, which indicates that the material is not toxic. In conclusion, collagen-hydroxyapatite-colostrum combination is an excellent biomaterial candidate for bone repair and bone infection management.

Copyrights © 2014






Journal Info

Abbrev

IJTID

Publisher

Subject

Earth & Planetary Sciences Health Professions Medicine & Pharmacology Public Health

Description

This journal is a peer-reviewed journal established to promote the recognition of emerging and reemerging diseases specifically in Indonesia, South East Asia, other tropical countries and around the world, and to improve the understanding of factors involved in disease emergence, prevention, and ...