Indonesian Journal of Tropical and Infectious Disease
Vol 5, No 3 (2014)

BACTERIA CAUSED SEPSIS BIOMARKERS

Tjempakasari, Artaria ( Tropical and Infectious Disease Division - Department of Internal Medicine, Dr. Soetomo General Hospital - Faculty of Medicine Universitas Ailangga, Surabaya, Indonesia )
Nasronudin, Nasronudin ( Tropical and Infectious Disease Division - Department of Internal Medicine, Dr. Soetomo General Hospital - Faculty of Medicine Universitas Ailangga, Surabaya, Indonesia Institute of Tropical Disease - Universitas Airlangga, Surabaya, Indonesia )



Article Info

Publish Date
06 Jul 2015

Abstract

Sepsis is a clinical condition of patients with serious infections that show a systemic inflammatory response, with or without a positive blood culture. sepsis is one of the most frequent causes of death in patients in intensive care units. We are at urgent need for biomarkers and reliable measurements that can be applied to risk stratification of septic patients and that would easily identify those patients at the highest risk of a poor outcome. Such markers would be of fundamental importance to decision making for early intervention therapy. Pro-inflammatory cytokines such as tumor necrosis factor- (TNF- ), interleukins-1,-6,-8 (IL-1, IL-6, IL-8) are postulated to play a major role in the pathogenesis of the syndrome. C-reactive protein (CRP) and procalcitonin (PCT) are among a few biomarkers thatincorporated into clinical practice although their precise role in the pathopysiology of sepsis and organ dysfunction still unclear.

Copyrights © 2014






Journal Info

Abbrev

IJTID

Publisher

Subject

Earth & Planetary Sciences Health Professions Medicine & Pharmacology Public Health

Description

This journal is a peer-reviewed journal established to promote the recognition of emerging and reemerging diseases specifically in Indonesia, South East Asia, other tropical countries and around the world, and to improve the understanding of factors involved in disease emergence, prevention, and ...