Atom Indonesia Journal
Vol 41, No 2 (2015): August 2015

The Use of Sodium Hypochlorite Solution for (n,γ)99Mo/99mTc Generator Based on Zirconium-Based Material (ZBM)

Saptiama, I. ( Center for Radioisotope and Radiopharmaceutical Technology, National Nuclear Energy Agency Puspiptek Area Serpong, Tangerang 15314, Indonesia )
Marlina, M ( Center for Radioisotope and Radiopharmaceutical Technology, National Nuclear Energy Agency Puspiptek Area Serpong, Tangerang 15314, Indonesia )
Sarmini, E. ( Center for Radioisotope and Radiopharmaceutical Technology, National Nuclear Energy Agency Puspiptek Area Serpong, Tangerang 15314, Indonesia )
Herlina, H ( Center for Radioisotope and Radiopharmaceutical Technology, National Nuclear Energy Agency Puspiptek Area Serpong, Tangerang 15314, Indonesia )
Sriyono, S ( Center for Radioisotope and Radiopharmaceutical Technology, National Nuclear Energy Agency Puspiptek Area Serpong, Tangerang 15314, Indonesia )
Abidin, A ( Center for Radioisotope and Radiopharmaceutical Technology, National Nuclear Energy Agency Puspiptek Area Serpong, Tangerang 15314, Indonesia )
Setiawan, H. ( Center for Radioisotope and Radiopharmaceutical Technology, National Nuclear Energy Agency Puspiptek Area Serpong, Tangerang 15314, Indonesia )
Kadarisman, K ( Center for Radioisotope and Radiopharmaceutical Technology, National Nuclear Energy Agency Puspiptek Area Serpong, Tangerang 15314, Indonesia )
Lubis, H. ( Center for Radioisotope and Radiopharmaceutical Technology, National Nuclear Energy Agency Puspiptek Area Serpong, Tangerang 15314, Indonesia )
Mutalib, A. ( Department of Chemistry, Faculty of Mathematics and Natural Science, Padjadjaran University Jl. Raya Bandung-Sumedang Km.21 Jatinangor, Sumedang 45363, Indonesia )



Article Info

Publish Date
08 Oct 2015

Abstract

The many problems in preparing fission product 99Mo led into this work to develop 99Mo/99mTc generator using neutron-irradiated natural MoO3 targets and, more specifically, to develop a zirconium-based material (ZBM) for chromatography columns that have an adsorption capacity of more than 100 mg Mo/g ZBM. This paper reports our recent experiments in the use of sodium hypochlorite solution of various concentrations to improve the yield of 99mTc in performance of (n,γ)99Mo/99mTc generators based on the ZBM. The synthesized ZBM was coated with tetraethyl orthosilicate for improving the hardness of the material. The adsorption of [99Mo]molybdate into ZBM was carried out by reacting ZBM into [99Mo]molybdate solution at 90°C to form ZBM-[99Mo] molybdate. ZBM-[99Mo]molybdate was then packed into generator column, then eluted with 10 × 1 mL of saline followed by 1 × 5 mL of NaOCl solution. The NaOCl solution concentrations used were 0.5%; 1%; 3%; and 5% for each column, respectively. This study resulted in a ZBM which has a 99Mo adsorption capacity of 167.5 ± 3.4 mgMo/g ZBM, as well as in a yield eluate of 99mTc of up to 70%, and the find that the optimum NaOCl concentration was 3%. The use of sodium hypochlorite solution affected 99Mo breakthrough. The higher sodium hypochlorite concentration used, the more 99Mo breaktrough exist on 99mTc eluate.Received: 22 October 2014; Revised: 21 April 2015; Accepted: 21 May 2015

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Journal Info

Abbrev

aij

Publisher

Subject

Materials Science & Nanotechnology

Description

Exist for publishing the results of research and development in nuclear science and technology Starting for 2010 Atom Indonesia published three times a year in April, August, and December The scope of this journal covers experimental and analytical research in all areas of nuclear science and ...