Journal of Dentistry Indonesia
Vol 10, No 1 (2003): APRIL

THE EFFECT OF OESTROGEN AND OR CALCIUM VITAMIN D3 ON THE MANDIBULAR HEIGHT OF POST OVARIECTOMIZED WISTAR RATS


Henri, Henri D. ( Faculty of Dentistry, Universitas Indonesia, Jakarta 10430 ) , Erwin, Erwin ( Faculty of Dentistry, Universitas Indonesia, Jakarta 10430 ) , Jimmy, Jimmy G. ( Faculty of Dentistry, Universitas Indonesia, Jakarta 10430 ) , Djamal, Niniarty Z. ( Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta 10430 ) , Fatma, Dewi ( Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta 10430 ) , Soekanto, Sri Angky ( Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta 10430 )



Article Info

Publish Date
30 Jul 2015

Abstract

One of the major health problems in elderly women is osteoporosis post menopause. Dentists must be aware of the disease since its involvement on the jaw. Nowadays, there are a lot of researches on correlation of osteopororsis and mandible but only few concentrate on hormonal substitution therapy and/or Calcium-vitamin D3 (Ca-Vit D3). This research is to evaluate the effect of hormonal substitiution therapy and/or Ca-vit D3 on mandibular height. Forty five rats used in this research and divided into nine groups: one control group, two ovariectomized (OVX) groups, two OVX groups treated with estrogen, two OVC groups treated with Ca-vit D3, two OVC groups treated with estrogen and Ca-vit D3. All of the rats except the control group were ovariectomized as model for postmenopausal estrogen deficiency state. The treatment was done in two or four weeks. The animals were killed with cervical dislocation, the mandible were excised and soaked on Hydrogen Peroxide 10%. Then the mandibles heights on right buccal side were measured from the manduble base to the alveolar crest. It is concluded that hormonal substitution therapy and combination of the hormonal substitution therapy and Ca-vit D3 can maintain the normal mandibular height. Mandibular height of groups with therapy using Ca-vit D3 have slightly lower means compared to control group but without significant difference statistically. The best therapy is combination of hormonal substitution therapy and Ca-vit D3.


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Journal Info

Abbrev

JDI

Publisher

Subject

Dentistry Medicine & Pharmacology

Description

Journal of Dentistry Indonesia (JDI) is a scientific journal that is published three times annually (April, August and December). This journal aims for continuous dissemination of updates in relation to dentistry and its related fields in the form of original articles, case reports and reviews. Its ...