Journal of the Indonesian Medical Association
Vol. 59 No. 11 November 2009

Biochemical Markers in Stroke

Immanuel, Suzanna ( Faculty of Medicine University of Indonesia, Jakarta )
Utami, Lidya ( Faculty of Medicine University of Indonesia, Jakarta )



Article Info

Publish Date
30 Nov 2009

Abstract

Stroke is a clinical syndrome marked by sudden partial or total neurologic deficit, due to impaired brain vessels. Stroke is a potentially fatal neurologic emergency with abrupt onset. Prompt and accurate diagnosis is very crucial for a successful management of patients with stroke. Thrombolytic therapy has been proven to improve the outcome in patients with ischemic stroke if administered within 6 hours after onset and after the possibility of intracranial hemorrhage has been eliminated. Recently, some biochemical markers for brain ischemia has been developed, which is expected to be readily available kits for rapid diagnosis of stroke. The markers for the early diagnosis of stroke include GFAP, PARK7, NDKA, NSE, and FABP. GFAP is a specific marker for brain and can be used to distinguish between ischemic and hemorrhagic stroke. Protein S-100B can also be useful as early marker for stroke if used in conjunction with other markers. Biochemical markers can also predict the extent of lesion and outcome. Until now, there is no apparent single biochemical marker which can fulfil the criteria of ideal marker for the diagnosis of stroke. Biochemical markers for stroke are more useful if used together in a panel.Keywords: stroke, biochemical markers, GFAP, S-100B

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