Media Gizi Mikro Indonesia
Vol 5, No 2 (2014)

Suplementasi Besi Mampu Memperbaiki Kadar Hormon TSH Anak Sekolah di Daerah Endemik GAKI


Nurcahyani, Yusi Dwi ( Balai Litbang GAKI Magelang ) , Mulyantoro, Donny Kristanto, Ashar, Hadi



Article Info

Publish Date
27 Jan 2015

Abstract

ABSTRACT Multiple nutritional and environmental influences contribute to the prevalence and severity of IDDs in iodine deficient areas, including iron. In many developing countries, children are at high risk of both goiter and iron deficiency anemia. Iron deficiency adversely affects thyroid metabolism and may reduce the efficacy of iodized salt. The aim of this study was to investigate whether iron supplementation can improve thyrothrophin hormone in school children in iodine deficient areas. A trial of iron supplementation was carried out in an area of endemic goiter in Kertek Wonosobo (n = 35), another group given placebo (n = 35). At baseline, anthropometri, TSH, ferritin, urinary iodine excretion and level of iodized salt were measured. After 13 weeks supplementation, the same data collecting was conducted. Supplement’s compliance during the study reached 100%. Two subject were excluded from from the analysis because they have extreme bio chemical data than the overall average. Statistical test showed no differences in age and gender proportion between groups. There were no significant difference in nutritional status, level of EIU, and level of iodine in salt between groups after the intervention, but there was a significant increase in ferritin level in the iron group (31.0 vs 44.8 μg/l, p<0.05). There were a significant difference in protein and iron intake, but no significant different in energy intake.These two group did not differ in TSH level change. After taking into account the modification variable effect of adequate protein > 70% RDA, the effect of iron supplementation was proved to be effective in changing TSH level (p <0.05). Our result indicate that increase in iron status can improve TSH hormone after considering adequate protein intake (RDA). Keywords : IDD, iron supplementation, thyroid function.   ABSTRAK Di daerah yang kekurangan iodium, pengaruh gizi dan lingkungan berkontribusi pada prevalensi dan tingkat keparahan GAKI, termasuk defisiensi mikronutrien lain diantaranya zat besi. Di negara berkembang, banyak anak-anak menderita GAKI dan defisiensi besi secara bersamaan. Defisiensi besi dapat mengganggu metabolisme tiroid dan mengurangi efektivitas garam beriodum. Penelitian ini bertujuan mempelajari pengaruh suplementasi besi dosis 60 mg/minggu terhadap hormon tiroid pada anak sekolah di daerah endemik GAKI. Suplementasi besi diberikan pada anak sekolah dasar umur 9-12 tahun di daerah dengan kasus kretin, di Kertek Wonosobo (n = 35) dan kelompok lainnya mendapatkan plasebo (n = 35). Awal penelitian dilakukan pengukuran antropometri, kadar TSH, ferritin, UIE dan kadar garam. Setelah 13 minggu suplementasi dilakukan pengukuran yang sama. Tingkat kepatuhan subyek mengonsumsi bahan intervensi 100%, tetapi 2 orang dikeluarkan dari analisis karena data biokimia yang ekstrim dibandingkan rerata keseluruhan. Umur dan jenis kelamin subyek tidak berbeda secara statistik. Setelah suplementasi, status gizi, kadar UIE dan kadar iodium dalam garam tidak berbeda nyata, tetapi ada peningkatan kadar ferritin yang signifikan pada kelompok Fe (31.0 menjadi 44.8 μg/l, p <0.05). Ada perbedaan asupan protein dan zat besi yang signifikan (p <0.05) antara kelompok Fe dan plasebo, tetapi tidak pada asupan energi. Tidak ada perbedaan perubahan kadar TSH yang signifikan antara kelompok Fe dan plasebo. Setelah memperhitungkan efek modifikasi (kecukupan protein >70% AKG), terbukti suplementasi besi berpengaruh terhadap perubahan TSH (p <0.05). Peningkatan status besi dapat memperbaiki hormon TSH setelah memperhitungkan tingkat kecukupan protein (AKG). Kata kunci: GAKI, suplementasi besi, fungsi tiroid.


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Original Source : http://ejournal.litbang.depkes.go.id/index.php/mgmi/article/view/3710
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Journal Info

Abbrev

mgmi

Publisher

Subject

Health Professions

Description

Media Gizi Mikro Indonesia (Indonesian Journal of Micronutrient) is a scientific journal published periodically by the Center for Research and Development of Iodine Deficiency Disorders (BPP GAKI), regularly twice a year. A paper published in the form of text / article the results of research and ...