STIFAR - Sekolah Tinggi Ilmu Farmasi
MFI Vol 8 No 1

PROFIL FARMAKOKINETIKA NATRIUM DIKLOFENAK SETELAH PEMBERIAN JUS SAWI HIJAU (Brassica rapa var. parachinensis L.) PADA TIKUS PUTIH JANTAN GALUR WISTAR

Puspitaningrum, Ika ( Ika Puspitanigrum(1), Endang Sri Sunarsih(2), Puspita Sari (3) 1,3) Program Studi S1 Farmasi Sekolah Tinggi Ilmu Farmasi Yayasan Pharmasi 2)¬Fakultas Kedokteran Universitas Diponegoro Semarang )
Sunarsih, Endang Sri ( Ika Puspitanigrum(1), Endang Sri Sunarsih(2), Puspita Sari (3) 1,3) Program Studi S1 Farmasi Sekolah Tinggi Ilmu Farmasi Yayasan Pharmasi 2)¬Fakultas Kedokteran Universitas Diponegoro Semarang )
Sari, Puspita ( Ika Puspitanigrum(1), Endang Sri Sunarsih(2), Puspita Sari (3) 1,3) Program Studi S1 Farmasi Sekolah Tinggi Ilmu Farmasi Yayasan Pharmasi 2)¬Fakultas Kedokteran Universitas Diponegoro Semarang )



Article Info

Publish Date
22 Jul 2014

Abstract

Induction of the enzyme is an important rule that has found implications in pharmacology and toxicology of a drug. Due to the induction of  biotransformation enzymes, the rate as will increase. Mustard green (Brassica rapa var. parachinensis L.) is one of vegetable which is  liked by the people of Indonesia. The content of indole in the mustard green can act as enzyme in the biotransformation of diclofenac. So it can decrease the number of active diclofenac inflammatory therapy. this research is an experiment using 21 white male rats of  wistar strain fasted for 12 hours divided into 3 groups each group contains 7 animals,than in their blood taken through orbital vein at  0, 0.5, 0.75, 1, 1.5, 2, 3, 4, 6, 8, 11 hours. Determination of diclofenac sodium performed with UV spectrophotometer at wavelength of 278 nm. Calculated pharmacokinetic parameters are (Ke, t ½, Ka, tmaks, AUC, Cpmaks, Vd, Cl). The parameters are calculated based on a compartment and analyzed statistically by anova test using SPSS version 13:00. The results showed the provision of mustrad green juice for 1 day with a dose of 35.28 g / kg weight for rats and 7 days with a dose of 5.04 g / kg weight for rats before given diclofenac sodium, the Clereance of diclofenac sodium can increase by 24.3479%, and 33, 38% (P <0.05) and  Cpmaks decreased by 50.90% and 68.57% (P> 0.05). Key words: mustard greens, induction, sodium diclofenac, pharmacokinetics

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