Müller, Robert
IJFAC (Indonesian Journal of Fundamental and Applied Chemistry)

Published : 1 Documents
Articles

Found 1 Documents
Search

Studies on the Controlled Release of Drugs from Magnetic Nanobiocomposites Heinze, Thomas; Müller, Robert; Zhou, Mengbo; Rabel, Martin; Warncke, Paul; Fischer, Dagmar
IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Vol 4, No 1 (2019): February 2019
Publisher : IJFAC (Indonesian Journal of Fundamental and Applied Chemistry)

Show Abstract | Original Source | Check in Google Scholar | Full PDF (374.706 KB)

Abstract

Magnetic nanocomposites are a class of smart materials that have attracted recent interest as drug delivery systems or as medical implants. In this study, meltable nanobiocomposites (NBC) composed of biocompatible dextran fatty acid ester and magnetic nanoparticles (MNPs) melting close to human body temperature were prepared and loaded with Rhodamine B (RhB) or green fluorescent protein (GFP) as model drugs to evaluate their potential use as drug delivery system. The release of the model drugs from the magnetic NBC investigated under the influence of a high frequent alternating magnetic field (AMF, 20 kA/m at 400 kHz) showed that on-demand release is realized applying the external AMF. The NBC showed a long-term stability (28 d) of the incorporated iron oxide particles after incubation in artificial body fluids. This work reveals the potential of the NBC as a drug carrier.