Yeni, Hervita
Fakultas Kedokteran Universitas Andalas

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Angka Ketahanan Hidup 3 Tahun Pasien Kanker Anak di RSUP Dr. M. Djamil Padang Yeni, Hervita; Izzah, Amirah Zatil; Arbi, Firman
Jurnal Kesehatan Andalas Vol 7 (2018): Supplement 4
Publisher : Fakultas Kedokteran Universitas Andalas

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Abstract

Latar belakang: Kejadian kanker pada anak terus meningkat dan menjadi masalah kesehatan dunia. Angka ketahanan hidup pasien dengan keganasan semakin meningkat sejalan dengan berjalannya kemoterapi dan modalitas terapi untuk keganasan lainnya.Tujuan: Mengetahui angka ketahanan hidup 3 tahun pasien kanker anak yang di rawat di RSUP Dr. M Djamil Padang.Metode: Penelitian secara retrospektif, menggunakan data rekam medik anak yang didiagnosis kanker di RSUP Dr M Djamil Padang dari 1 Januari 2013 – 31 Desember 2013. Data diambil pada Maret 2016. Kriteria inklusi adalah seluruh pasien kanker anak yang didiagnosis tahun 2013. karakteristik pasien dan status kehidupan saat ini dicatat. Angka ketahanan hidup dihitung menggunakan metode Kaplan Meier.Hasil: Terdapat 29 pasien kanker anak tahun 2013 dengan kelompok usia terbanyak 1-4 tahun (48,3%) dengan jumlah laki-laki dan perempuan hampir sama. Leukemia akut limfoblastik (ALL) merupakan kanker anak terbanyak (22 orang, 75,9%). Dari 29 pasien kanker anak 20 (69%) diantaranya masih bertahan hidup, 6 orang (20,7%) meninggal dan 3 orang (10,3%) tidak diketahui. Angka ketahanan hidup 3 tahun pasien kanker anak secara keseluruhan adalah 76,9%. Angka ketahanan hidup 3 tahun pada pasien leukemia limfoblastik akut 94,7%.Kesimpulan: Angka ketahanan hidup anak dengan keganasan di RSUP Dr M Djamil Padang cukup baik.
Relationship between serum ferritin and zinc levels in patients with major thalassemia Yeni, Hervita; Yani, Finny Fitry; Izzah, Amirah Zatil; Lubis, Gustina
Paediatrica Indonesiana Vol 59 No 3 (2019): May 2019
Publisher : Indonesian Pediatric Society

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Abstract

Background In thalassemia patients, reduced zinc absorption results from increased serum iron due to repeated blood transfusions, increased iron absorption due to ineffective erythropoiesis, and competitive inhibition between iron and zinc in binding to transferrin, a means of transporting both types of minerals in the blood. Few studies have been done to examine zinc levels in thalassemia patients and its relationship with ferritin. Objective To compare serum zinc in thalassemia patients and healthy controls and to assess for a possible correlation between serum ferritin and zinc in thalassemia patients. Methods This cross-sectional study in 68 subjects was done from October 2016 to August 2017. Serum ferritin measured by chemiluminescence immunoassay and serum zinc by inductively coupled plasma mass  spectrometry (ICP-MS). Wilcoxon test was used to analyze for differences between serum zinc in thalassemia patients and controls. Spearman’s correlation test was used to analyze for a possible correlation between ferritin and serum zinc in thalassemia patients. Results There were 34 patients with thalassemia and 34 healthy control subjects. The median serum zinc was 119.34 µg/dL (IQR=71.27) in the thalassemia group and 120.08 µg/dL (IQR=26.28) in the control group (P=0.36). There was no significant correlation between serum ferritin and zinc in thalassemic children (r=-0.023; P=0.895). Conclusion There is no significant difference in serum zinc levels between thalassemic children and healthy controls. There is  no significant correlation between serum ferritin and zinc in thalassemic children.