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UJI AKTIVITAS PENGHAMBATAN XANTIN OKSIDASE EKSTRAK ETANOL 80% DARI TANAMAN FAMILI COMBRETACEAE, LAURACEAE, LYTHRACEAE, OXALIDACEAE, PIPERACEAE, PLUMBAGINACEAE, DAN SMILACACEAE

FITOFARMAKA | Jurnal Ilmiah Farmasi Vol 6, No 2 (2016): Vol.6, No.2, Desember 2016
Publisher : Universitas Pakuan

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Abstract

ABSTRAK Hiperurisemia dapat disebabkan oleh produksi berlebih dan kurangnya ekskresi asam urat dalam tubuh. Xantin oksidase adalah enzim yang memiliki peran mengkatalisis oksidasi hipoxantin dan xantin menjadi asam urat. Tujuan penelitian ini adalah untuk mengetahui tanaman obat yang memiliki aktivitas penghambatan xantin oksidase dan mengidentifikasi golongan senyawa kimianya. Metode yang digunakan adalah Continous Spectrophotometric Rate Determination. Serbuk simplisia diekstrak dengan cara refluks menggunakan pelarut etanol 80%. Dengan uji aktivitas penghambatan xantin oksidase didapatkan ekstrak yang memiliki aktvitas penghambatan, yaitu ekstrak herba suruhan (Peperomia pellucida (L.) Kunth), ekstrak daun blimbing wuluh (Averrhoa bilimbi L.), ekstrak daun sirih (Piper betle L.), dan ekstrak kulit kayu manis (Cinnamomum burmannii Nees ex Blume) yang memiliki nilai IC50 berturut-turut 2621,07 ppm, 1149,113 ppm, 245,30 ppm, dan 1294,58 ppm. Identifikasi kimia pada ekstrak herba suruhan menunjukkan adanya alkaloid, flavonoid, tanin, saponin, dan glikosida. Pada ekstrak daun belimbing wuluh mengandung senyawa flavonoid, tanin, dan saponin. Pada eksktrak daun sirih hijau mengandung senyawa alkaloid, flavonoid, tanin, saponin, dan antrakuinon. Pada ekstrak kulit kayu manis mengandung senyawa alkaloid, flavonoid, tanin, saponin Kata kunci: suruhan, blimbing wuluh, sirih, kayu manis, hiperurisemia, aktivitas inhibitor, xantin oksidase

FORMULASI GEL TOPIKAL DARI EKSTRAK NERII FOLIUM DALAM SEDIAAN ANTI JERAWAT

JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 4, No 4 (2009)
Publisher : Indonesian Research Gateway

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Abstract

The leaf of Nerium oleander has an antibacterial activity toward some microorganisms and empirically had been used to solve the acne problem. The anti acne formulation should not make the acne worse because of mistaken to choose the dosage form. In this study the gel formulation (has no oil content makes the acne worse) was chosen containing the dried leaf extract of Nerium oleander in 97% alcohol and varying respectively carbomer, sodium carboxy methyl cellulose and sodium alginate as a gelling agent. The efficacy test was confirmed by the extract antibacterial activity test upon Propionibacterium acnes bacterium causing acne, and the gel formula evaluation test was done by physical stability test including organoleptical test (color and odor), pH, viscosity stored in low temperature of 40C, room temperature of 280C, and high temperature of 400C, cycling test and mechanical test. The results showed that carbomer gel has better physical stability than sodium CMC or sodium alginate gel. ABSTRAK Daun Nerium oleander mempunyai aktifitas antibakteri terhadap beberapa mikroba dan secara empiris telah digunakan untuk mengatasi masalah jerawat. Formula yang layak untuk dibuat menjadi sediaan anti jerawat seyogyanya tidak memperburuk gangguan jerawat itu sendiri karena pemilihan bentuk sediaan yang tidak tepat. Bentuk sediaan gel dipilih karena tidak mengandung bahan minyak yang akan memperburuk jerawat. Formulasi sediaan gel untuk mengatasi jerawat ini mengandung ekstrak Nerium oleander dalam etanol 97% yang telah dikeringkan, sedangkan untuk basis gelnya dicoba bahan karbomer, Natrium CMC, dan Na alginate. Penilaian keberhasilan untuk pemastian manfaat dilakukan dengan uji aktifitas ekstrak terhadap bakteri Propionibacterium acnes penyebab jerawat, sedang terhadap keberhasilan formula dilakukan uji kestabilan fisik sediaan gel yang meliputi uji organoleptik (warna, bau), pH, dan viskositas selama masa penyimpanan dalam suhu rendah (4oC), suhu kamar (28oC) dan suhu tinggi (40oC). Dilakukan juga cycling test dan uji mekanik terhadap sediaan gel tersebut. Hasilnya menunjukkan bahwa gel berbasis karbomer memiliki kestabilan fisik yang lebih baik daripada gel berbasis Natrium CMC maupun Natrium alginat.

Formulation, Characterization and In Vitro Penetration Study of Resveratrol Solid Lipid Nanoparticles in Topical Cream

JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 2 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Indonesia

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Abstract

There are many target sites in the skin layer that will be demage as the cause of oxidative stress, including lipids, DNA and proteins. Oxidative damage of skin can be prevented by using topical antioxidant. Resveratrol is a polyphenol antioxidant from grape seed oil, shows a potent antioxidant activity that could be beneficial in skin protection from oxidative stress. The objective of this research was to develop solid lipid nanoparticles (SLNs) of resveratrol and to evaluate the potential of SLNs as nanovesicle to penentrate through the skin layer. The SLN of resveratrol was prepared by solvent emulsification method. The developed SLN resveratrol were characterized for particle size, polydispersity index, entrapment efficiency and morphology. Resveratrol loaded SLN with glyceryl monostearate 0.5% displayed spherical morphology with particle size of 334.4±8.95 nm, polydispersity index of 0.289±0.062, entrapment efficiency of 48.706±1.319% and zeta potential of –27.53±0.802 mV. In vitro permeation studies of cream enriched with SLN resveratrol 10% showed fluks 6.64±0.19 μg/cm2/hour while fluks of cream enriched with resveratrol alone was 6.09±0.84 μg/cm2/hour.

Pemanfaatan Nanoteknologi dalam Sistem Penghantaran Obat Baru untuk Produk Bahan Alam

JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 2 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Indonesia

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Abstract

Natural products have been known to have a major role in maintaining health. Some studies reported that they demonstrated various pharmacological activities and provided a lead compound or drug candidate. Isolated compounds from the extracts have been studied both in vitro and in vivo to determine their effects and bioavailability in the body. However, more than 40% natural products have low solubility in water, or even give a high toxicity. Low solubility in water and the lack of ability to penetrate the absorption barrier may affect the bioavailability in the body. Furthermore, the bioavailability of a compound is also influenced by the stability of drugs in the pH of the stomach and colon, metabolism by normal microflora in the digestive tract, absorption through the intestinal wall, efflux pumps mechanism and first-pass metabolism. Solution to overcome these problems is by developing a drug delivery system known as a novel drug delivery system (NDDS). The NDDS is a more modern system to control the release of drugs so that it will give better pharmacological activity. Making dosage forms based on this novel technology can be an alternative for manufacturing herbal products. It can increase their bioavailability in the body so that it can provide a better therapeutic effect.

Aktivitas Gastroprotektif Kombinasi Ekstrak Kulit Batang Mimba (Azadirachta indica A. Juss) dan Rimpang Kunyit (Curcuma domestica Linn.) pada Tikus Putih yang Diinduksi Asetosal

JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 2 (2013): JIFI
Publisher : Fakultas Farmasi Universitas Indonesia

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Abstract

Kulit batang mimba (Azadirachta indica A. Juss) dan rimpang kunyit (Curcuma domestica Linn.) dilaporkan memiliki aktivitas gastroprotektif baik secara preklinik maupun klinik. Tujuan penelitian ini adalah untuk mengetahui efek sinergis kombinasi ekstrak kulit batang mimba dan rimpang kunyit pada tikus putih yang diinduksi asetosal. Kombinasi ekstrak ini diberikan dengan berbagai dosis selama 7 hari secara oral. Pada hari ke-8 dilakukan induksi tukak lambung dengan pemberian asetosal 400 mg/kg bb. Tikus dibedah 8 jam setelah pemberian asetosal untuk dilakukan perhitungan indeks ulkus, determinasi mukus, pemeriksaan keasaman lambung dan histologi. Kombinasi ekstrak kulit batang mimba (250 mg/kg bb) dan rimpang kunyit (50 mg/kg bb) menurunkan indeks ulkus dan meningkatkan ketebalan mukus secara bermakna (a = 0,05), hal ini juga didukung oleh pemeriksaan histologi lambung. Berdasarkan penelitian ini dapat disimpulkan bahwa kombinasi ekstrak kulit batang mimba dan rimpang kunyit memiliki efek sinergis gastroprotektif.

Analisis Penerapan dan Sistem Bagi Hasil Akad Mudharabah Dalam Akuntansi Syariah

Jurnal Ilmu Manajemen Advantage Vol 3 No 1 (2019): Juni 2019
Publisher : Jurnal Ilmu Manajemen Advantage

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Abstract

Islam is the religion that is most widely adhered to by the people of  Indonesia, so it is not surprising that since before the year two thousand Islamic banks have emerged in this country, starting from Bank Muamalat which was first in Indonesia and then independent Islamic Banks to various conventional banking systems which opened the. In Islamic banking itself, there are many products offered, ranging from pure savings, financing to Islamic banking services like a conventional one, but there are fundamental principles that distinguish between the two. Therefore there is a need for further understanding of Islamic banking products Through this research, it is expected that the implementation and system of profit sharing in the Mudharabah contract in sharia accounting will be well known and in accordance with Sharia PSAK and the fatwa of the national sharia council (DSN). The results of this study are that the results of the mudharabah contract and sharia accounting are of two types, namely profit loss sharing, and revenue sharing, these two methods can be used in determining profit sharing in carrying out mudharabah contracts.