Burhan, Asril
Faculty of Medicine, Universitas Islam Indonesia

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The effect of kersen's skin infusion (Muntingia calabura L.) on blood uric acid levels of the rats (Rattus novergicus) Burhan, Asril; Usmar, Usmar; Zulham, Zulham; Andarwiyati, Ana
Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 9, No 3, (2018)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol9.Iss3.art7

Abstract

Background: Uric Acid or Gout is the results of purine metabolism, i.e. the enzymatic reshuffle of body cells from dinucleotide or ribonucleotide acids. High uric acid levels can be settled in the central joints and mesenchymal tissues such as the kidney.Objective: To determine an effect of administering the Kersen's (Muntingia calabura L.) ripe skin infusion against uric acid levels in the rats which have been induced with caffeine.Methods: Eighteen rats was divided into six groups, i.e. three as a control group (negative, positive and normal) and three as a treatment group (0,5%, 1%, and 2% doses). The measurements of blood uric acid levels were performed before induction, after induction and after treatment on 9th, 12nd, and 15th days. Results: There was a reduction of the uric acid levels in the rats which administered by ripe Kersen's fruit skin infusion at 1% with 3,43 mg/dL and 2% with 3.32 mg/dL doses. However, this reduction is not equivalent to the effect of allopurinol control decreased at 2.9 mg/dL. Statistical analysis results with Complete Randomized Design (RAL) revealed that positive control group, infusion in 1% and 2% dose did not have a significant difference with normal controls, that means allopurinol and both doses test give an effect to return the uric acid to normal conditions.Conclusion: The ripe Kersen's (Muntingia Calabura) fruit skin infusion provides a reduction effect on blood uric acid levels in the rats (Rattus Novergicus) that have been induced by caffeine. Concentration of infusion that reduced effect of blood uric acid levels in the rats are at 1% ( 1 g/ 200 gBW) and 2% (2 g/200 gBW). However, the reduction is not equivalent to the positive control of Allopurinol.
UJI AKTIVITAS HIPOGLIKEMIK EKSTRAK DAUN PISANG KEPOK KERING (Musa paradisiaca forma typica) TERHADAP MENCIT JANTAN (Mus musculus) Burhan, Asril; Hardianti, Besse; Mujilah, Mujilah
Media Kesehatan Politeknik Kesehatan Makassar Vol 14, No 1 (2019): Media Kesehatan
Publisher : Politeknik Kesehatan Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (167.185 KB) | DOI: 10.32382/medkes.v14i1.748

Abstract

Diabetes melitus merupakan gangguan kronis yang bercirikan hiperglikemia (peningkatan glukosa dalam darah) akibat pankreas tidak mampu memproduksi cukup insulin. Penelitian ini bertujuan untuk mengetahui aktivitas hipoglikemik ekstrak daun pisang kepok kering (Musa paradisiaca forma typica). Hewan uji yang digunakan sebanyak 15 ekor mencit jantan (Mus musculus) dibagi dalam 5 kelompok terdiri dari kontrol positif (Glibenklamid), kontrol negatif (Na-CMC 0,5%), ekstrak dosis 5,6 mg/20 gBB, ekstrak dosis 11,2 mg/20 gBB dan kontrol sehat. Sebelum dilakukan perlakuan mencit dipuasakan selama 8 jam danĀ  diukur glukosa darah awal kemudian di induksi glukosa selama 8 hari. Setelah diinduksi diukur glukosa darah kedua kemudian diberi perlakuan dan diukur glukosa darah mencit setelah perlakuan pada menit ke 30, 60, dan 90. Hasil yang diperoleh Ekstrak dosis 5,6 mg/20 gBB memberikan efek yang tidak berbeda nyata dengan kontrol positif dan kontrol sehat. Sedangkan dosis ekstrak dosis 11,2 mg/20 gBB tidak berbeda nyata dengan kontorl negatif. dapat disimpulkan bahwa ekstrak daun pisang kepok kering mengandung senyawa flavonoid yang dapat menurunkan kadar glukosa darah pada mencit yang hiperglikemia pada dosis 5,6 mg/20 gBB dan 11,2 mg/20 gBB.Kata kunci : Diabetes Melitus, Hiperglikemia, Ekstrak Daun Pisang Kepok Kering