Herlina, H
Center for Radioisotope and Radiopharmaceutical Technology, National Nuclear Energy Agency Puspiptek Area Serpong, Tangerang 15314, Indonesia

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The Use of Sodium Hypochlorite Solution for (n,γ)99Mo/99mTc Generator Based on Zirconium-Based Material (ZBM) Saptiama, I.; Marlina, M; Sarmini, E.; Herlina, H; Sriyono, S; Abidin, A; Setiawan, H.; Kadarisman, K; Lubis, H.; Mutalib, A.
Atom Indonesia Vol 41, No 2 (2015): August 2015
Publisher : PPIKSN-BATAN

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (337.436 KB) | DOI: 10.17146/aij.2015.384

Abstract

The many problems in preparing fission product 99Mo led into this work to develop 99Mo/99mTc generator using neutron-irradiated natural MoO3 targets and, more specifically, to develop a zirconium-based material (ZBM) for chromatography columns that have an adsorption capacity of more than 100 mg Mo/g ZBM. This paper reports our recent experiments in the use of sodium hypochlorite solution of various concentrations to improve the yield of 99mTc in performance of (n,γ)99Mo/99mTc generators based on the ZBM. The synthesized ZBM was coated with tetraethyl orthosilicate for improving the hardness of the material. The adsorption of [99Mo]molybdate into ZBM was carried out by reacting ZBM into [99Mo]molybdate solution at 90°C to form ZBM-[99Mo] molybdate. ZBM-[99Mo]molybdate was then packed into generator column, then eluted with 10 × 1 mL of saline followed by 1 × 5 mL of NaOCl solution. The NaOCl solution concentrations used were 0.5%; 1%; 3%; and 5% for each column, respectively. This study resulted in a ZBM which has a 99Mo adsorption capacity of 167.5 ± 3.4 mgMo/g ZBM, as well as in a yield eluate of 99mTc of up to 70%, and the find that the optimum NaOCl concentration was 3%. The use of sodium hypochlorite solution affected 99Mo breakthrough. The higher sodium hypochlorite concentration used, the more 99Mo breaktrough exist on 99mTc eluate.Received: 22 October 2014; Revised: 21 April 2015; Accepted: 21 May 2015