Loesnihari, Ricke
Fakultas Kedokteran USU

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Peran analisa urin pada penanganan penyakit ginjal dan traktus urinarius Loesnihari, Ricke
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 45, No 3 (2012): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Renal and urinary tract diseases can caused severe problem if its diagnose late. That is because Renal organs have ability to compensate and human can live normally with one renal organ. Urinalysis test as a screening test can be performed without any indication and there are parameters which are represent so many condition that are affected by renal function. Abnormal urinalysis may indicate renal and urinary tract disease or renal damage caused by other disease. The source of uncertain component in urine specimen were estimated on biological variation or influenced by end product of metabolism and the question is whether or not this approach represents good laboratory practice should be identified. In conclusion, urinalysis could detect chronic renal disease in its early stage and also good laboratory practice could give reliable result. Keywords: renal; urinalysis; proteinuria; urine sediment
Deteksi Immunoglobulin M dengan antigen Outer Membrane Protein (OMP) 50K-DA salmonella typhi pada demam tifoid E, Herawina; Lubis, Zulfikar; Loesnihari, Ricke
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 49, No 2 (2016): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Introduction : Typhoid fever is a systemic infectious disease caused by Salmonella typhi. That is still widely found in the world and many developing countries that are mainly located in the tropical and subtropical. Clinical diagnosis of typhoid fever is difficult because there is no typical clinical manifestation, therefore we need laboratory tests. Typhidot IgM  is one of serological examination is a rapid examination with  of detecting the presence of  antibodies IgM of Outer membrane protein (OMP) 50KDa antigen in Salmonella typhi.The aim of this study was to assess the sensitivity and specificity of the IgM antigen examination of  Outer membrane protein (OMP) 50KDa Salmonella typhi  with blood culture.Methods : The method that was used in this study was diagnostic testing to compare rapid examination Typhidot IgM with blood cultures in  adult patients ≥ 18 years old, with fever≥38º,  fever ≥3 days, who were diagnosed with suspected typhoid fever or typhoid fever based on Nelwan score in Haji Adam Malik Hospital.Results : The number of subjects are 29 people, with 25 positive Typhidot IgM (86%) and 11 positive blood cultures (38%). The examination results of Typhidot IgM towards blood culture showed 100% sensitivity, 22% specificity, 45%  positive predictive value and 100% negative predictive value.Conclusion : The results of rapid examination Typhidot IgM  showed a good sensitivity and a poor specificity, with a negative predictive value of 100% which indicates that  rapid examination Typhidot IgM can not be use a diagnostic examination but Typhidot IgM can be use as an initial screening examination this means that Typhidot IgM  able to get rid of a case that really is not typoid fever.Keyword : Typhoid fever, rapid test Typhidot , Blood Cultures.
Karakteristik Pendonor Darah dengan HIV Reaktif Positif Melalui Rapid Test HIV Tiga Metode Rajagukguk, Marlina; Loesnihari, Ricke; Amelia, Sri; Nasution, Tetty Aman; Sanuddin, Ozar
Global Medical & Health Communication (GMHC) Vol 6, No 1 (2018)
Publisher : Faculty of Medicine Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v6i1.2418

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Penyakit HIV/AIDS merupakan masalah besar yang mengancam Indonesia dan banyak negara di dunia. Keadaan ini menyebabkan krisis multidimensi bahkan kematian karena sekali terinfeksi akan tetap terinfeksi. Risiko penularan human immunodeficiency virus (HIV) melalui perilaku berisiko dan transfusi darah sebesar 90%. Penelitian ini bertujuan mengetahui hubungan faktor risiko pada pendonor darah dengan HIV reaktif positif menggunakan rapid test HIV tiga metode di Palang Merah Indonesia (PMI) Medan. Jenis penelitian ini adalah uji diagnostik dengan memakai rapid test HIV tiga metode pada 75 sampel darah pendonor yang dianggap berisiko. Penelitian dilakukan di Unit Transfusi Darah (UTD) PMI Medan sejak Desember 2015 sampai Juni 2016. Kriteria inklusi, yaitu memenuhi syarat donor yang ditetapkan PMI. Pendonor mempunyai karakteristik perilaku berisiko seperti pengguna jarum suntik (penasun), bertato/tindik, seks bebas, homoseks, pernah berobat kulit, dan pernah menerima transfusi darah. Hasil penelitian terdapat hubungan bermakna kejadian reaktif positif HIV secara rapid test HIV tiga metode dengan nilai p=0,031 sebagian besar reaktif positif memiliki lebih dari satu karakteristik. Dari 75 sampel darah berisiko didapat 19 sampel darah (0,25%) reaktif positif HIV dan 6 sampel (0,08%) indeterminate dan reagen yang paling efektif memeriksa adalah oncoprobe. Simpulan, pendonor dengan hasil reaktif positif HIV secara rapid test HIV tiga metode memiliki karakteristik perilaku berisiko lebih dari satu. CHARACTERISTICS OF BLOOD DONORS WITH HIV REACTIVE POSITIVE THROUGH THE THREE METHODS OF HIV RAPID TESTHIV/AIDS is a big problem that threatens Indonesia and many countries in the world. This situation causes multidimensional crises and even deaths because once a person  infected they will remain infected. The risk of transmission of human immunodeficiency virus (HIV) through risky behavior and blood transfusions by 90%. This study aims to determine the characteristic of blood donors with HIV reactive positive using three methods of HIV rapid test at Indonesian Red Cross (PMI) Medan. This study was a diagnostic test using three methods of HIV rapid test on 75 blood samples. The study considered to be at risk directly at blood donor site of Blood Transfusion Unit (UTD) PMI Medan from December 2015 to June 2016 with inclusion criteria that meet the donor requirements set by PMI and risky donors such as users of syringes (IDUs), tattoos/piercing, free sex, homosexuals, have had skin treatment and have received blood transfusions. The results of this study concluded that there was a significant association between HIV reactive positive occurrences in the three methods of HIV rapid test with p=0.031 where most reactive positive had more than one risk behavior. Of the 75 blood samples at risk in 19 blood samples (0.25%) were positively HIV reactive and six samples (0.08%) were indeterminate. The most effective reagent check was oncoprobe. In conclusions, blood donors with HIV reactive positive results in three methods of HIV rapid test have multiple risk factors.
Profil Resistensi Antimikroba dari Flora Normal dalam Kavum Nasi Petugas Kamar Operasi Bedah Jantung dan Petugas Pasca Operasi Intensive Coronary Care Unit RSUP H. Adam Malik Medan Irma, Fani A.; Loesnihari, Ricke; Akbar, Nizam
Jurnal e-Biomedik Vol 7, No 1 (2019): Jurnal e-Biomedik (eBM)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (273.641 KB) | DOI: 10.35790/ebm.7.1.2019.23535

Abstract

Abstract: Nosocomial infection often occurs in hospitalized patients due to microbial contamination. This study was aimed to obtain the profile of microbes in nasal cavities of hospital personnel by identification the microbial pattern, therefore, the microbial resistance to several antimicrobial groups could be determined. This was an observational analytical study with a cross sectional design. Subjects were hospital personnel at the Cardiac Surgery room and at the Intensive Coronary Care Unit (ICCU) room of H. Adam Malik General Hospital, Medan. Specimens of nasal cavity swabs were taken from all subjects, and then were cultured and tested for antimicrobial sensitivity. From 37 subjects, the most common bacteria found were S. epidermidis (40%), S. saprophyticus (21%), and S. aureus (12%). The antimicrobial susceptibility test showed that sufamethoxsazole had the highest resistance while erythomycin still had good sensitivity. At the ICCU room, amikacin showed better sensitivity than doxycyclin. Amoxiclav had the highest sensitivity, meanwhile from the floroquinolone class, norfloxacin had better sensitivity than ciprofloxacin. The microbes were still sensitive to cephalosporin class but were resistant to vancomycin. Conclusion: S. epidermidis, S. saprothyticus, and S. aureus were the most commonly found microbes in the nasal cavities of hospital personnel. The nasal cavity microbes were still sensitive to erythromycin, amikacin, amoxiclav, norfloxacin, and cephalosporin group.Keywords: nosocomial infection, nasal cavity, antimicrobial resistance, antimicrobial sensitivity Abstrak: Infeksi nosokomial sering terjadi pada saat pasien dirawat di rumah sakit akibat adanya kontaminasi mikroba yang berada di rumah sakit. Penelitian ini bertujuan untuk mendapatkan pola mikroba kavum nasi dari petugas rumah sakit melalui identifikasi mikroba sehingga dapat ditentukan pola resistensi mikroba terhadap berbagai macam golongan antimikroba. Jenis penelitian ialah analitik observasional dengan desain potong lintang. Subyek penelitian ialah petugas di kamar operasi bedah jantung dan ruang pasca operasi ICCU di RSUP H. Adam Malik Medan. Pengambilan spesimen swab kavum nasi dilakukan pada semua subyek, dilanjutkan dengan pembiakan serta uji resistensi antimikroba. Dari 37 subyek didapatkan bakteri terbanyak yaitu S. epidermidis (40%), diikuti oleh S. saprothyticus (21%), dan S. aureus (12%). Uji sensitivitas terhadap antimikroba lini pertama mendapatkan sulfametoksasol merupakan antimikroba yang paling tinggi resistensinya sedangkan eritromisin merupakan antimikroba yang masih baik sensitivitasnya. Untuk ruang ICCU, sensitivitas terhadap amikasin masih lebih baik dibandingkan doksisiklin. Amoksiklav merupakan antimikroba yang sensitivitasnya sangat baik, sedangkan dari golongan florokuinolon, norfloksasin memiliki sensitivitas yang lebih baik dibanding siprofloksasin. Golongan sefalosporin masih memiliki sensitifitas yang baik, sedangkan vankomisin sudah resisten. Simpulan: Bakteri terbanyak didapatkan dalam kavum nasi ialah S. epidermidis, S. saprothyticus, dan S. aureus. Antimikroba yang masih sensitif yaitu eritromisin, amikasin, amoksiklav, norfloksasin, dan golongan sefalosporin.Kata kunci: infeksi nosokomial, kavum nasi, resistensi antimikroba, sensitivitas antimikroba