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All Journal Jurnal Farmasi Klinik Indonesia
Gatera, Vesara A.
Indonesian Journal of Clinical Pharmacy
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Hubungan Pola Sensitivitas Bakteri pada Penggunaan Antibiotik Empirik terhadap Pencapaian Clinical Outcome Pasien Pneumonia Anak

Indonesian Journal of Clinical Pharmacy Vol 3, No 4 (2014)
Publisher : Indonesian Journal of Clinical Pharmacy

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Abstract

Pneumonia merupakan salah satu penyakit infeksi yang memerlukan upaya komprehensif dan efektif dalam penanganannya terutama dalam penggunaan antibiotik empiris. Penggunaan antibiotik empiris harus berdasarkan pola sensitivitas terhadap bakteri. Penelitian ini bertujuan untuk mengevaluasi penggunaan antibiotik berdasarkan pola sensitivitas dengan memperhatikan faktor clinical outcome pasien sebagai tujuan pengobatan. Penelitian ini dilaksanakan di RS Dr. Hasan Sadikin pada bulan Oktober–Desember 2013 dengan menerapkan desain potong lintang secara retrospektif. Data sekunder diperoleh dari rekam medis dalam kurun waktu Januari 2011–Desember 2012. Objek penelitian terdiri dari rekam medis 24 pasien berusia 1–5 tahun dengan hasil kultur positif dan menerima resep antibiotik. Hasil penelitian ini menunjukkan penggunaan sefotaksim-ampisilin sebesar 37,5%, sefotaksim 33,3%, ampisilin 20,8%, dan seftriakson 8,4%. Antibiotik yang paling memengaruhi pencapaian clinical outcome dengan taraf kepercayaan 95% adalah kombinasi sefotaksim-ampisilin (p=0,044) dengan tingkat sensitivitas 77,7%. Pola sensitivitas penggunaan antibiotik memengaruhi clinical outcome padapasien pneumonia anak.Kata kunci: Clinical outcome, pneumonia, sensitivitas antibiotikAssociation of Pattern of Bacteria Sensitivity During the Empirical Antibiotics Use to the Achievement of Clinical Outcome in Pediatric Patients with PneumoniaPneumonia is one of infectious diseases that require a comprehensive and effective effort in its treatment,including in the use of empirical antibiotics. The use of empirical antibiotics should be based on patterns of sensitivity toward bacteria. The aim of this study was to evaluate the use of antibiotics based on the sensitivity patterns by clinical outcomes as the goal of treatment. This study was conducted in Hasan Sadikin Hospital Bandung in October–December 2013 using a retrospective cross-sectional study design. Secondary data were obtained from medical records during January 2011–December 2012. This study consisted of 24 patients with positive culture test and received antibiotic prescription. The results showed the percentage of the use of cefotaxime-ampicillin (37.5%), cefotaxime (33.3%), ceftriaxone (20.8%), and ampicillin (8.4%). The most influential antibiotics for achieving clinical outcome using 95% confidence level is combination of cefotaxime-ampiciline (p=0.044) with 77.7% sensitivity level. This study suggested that the pattern of antibiotic sensitivity affected the clinical outcomes of pediatric patients with pneumonia.Key words: Clinical outcome, pneumonia, sensitivity of antibiotic