Situmeang, Boima
Jurnal Pendidikan Kimia (JPKim)

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Antimalarial activity and phitochemical analysis from Suruhan (Peperomia pellucida) extract

Jurnal Pendidikan Kimia (JPKim) Vol 8, No 3 (2016): Desember 2016
Publisher : Jurnal Pendidikan Kimia (JPKim)

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Abstract. Infectious and parasitic diseases is one of various disease that the most common. Based on data from the World Health Organization (WHO) in 2011, infectious and parasitic diseases become the third largest cause of death in the world. One of the plants that have potential as an antimalarial is suruhan (Peperomia pellucida). The purpose of this study is to test antimalarial activity against Plasmodium falciparum and analysis photochemistry consituen from extract suruhan. Antimalarial activity test using Desjardin method. Extraction was done by using maceration wuth methanol as a solvent and fractionation using partition methods. Results of phytochemical screening revealed the presence of alkaloids, flavonoid, steroid, saponins and triterpenoid test results antimalarial activity fraction of n-hexane, ethyl acetate and water show IC50 values are 12.80, 2.90 and 10.74 mg/ mL respectively. Keyword: Peperomia pellucida, suruhan, antimalarial

Analysis of secondary metabolite compounds from leaves extract kesambi (Schleichera oleosa) and antioxidant activity test

Jurnal Pendidikan Kimia (JPKim) Vol 8, No 3 (2016): Desember 2016
Publisher : Jurnal Pendidikan Kimia (JPKim)

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Abstract

Abstract. Kesambi (Schleichera oleosa) is one of plants that have the potential to treat various deasease. Kesambi plant or kusum widely spread in Asia such as India, Nepal, Malaysia and Indonesia. In Indonesia, this plant widely available in Java precisely Cilegon and Jember area. This study aimed to analyze the content of secondary metabolites from plants kesambi extract and antioxidant activity test of hexane, ethyl acetate and water fraction. Analysis of secondary metabolites is done with phytochemical and GC-MS test methods. Extraction was done by using maceration and fractionation methods. Antioxidan tactivity test using DPPH methods. The content of secondary metabolites contained in leaves kesambi (Schleichera oleosa) are flavonoids, alkaloids, tannins, phenols, and steroids. Based on IC50 values were obtained from three fraction, ethyl acetate fraction had a strong radical inhibition rate than the fraction of water and n-hexane. IC50 fraction of ethyl acetate, water, and n-hexane successively are: 206.0851; 272.2891 and 425,1143 ppm respectively. Keyword: kesambi, schleichera oleosa, DPPH, antioxidant

Analysis of secondary metabolite compounds from leaves extract kesambi (Schleichera oleosa) and antioxidant activity test

JURNAL PENDIDIKAN KIMIA (JPKim) Vol 8, No 3 (2016): Desember 2016
Publisher : JURNAL PENDIDIKAN KIMIA (JPKim)

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Abstract

Abstract. Kesambi (Schleichera oleosa) is one of plants that have the potential to treat various deasease. Kesambi plant or kusum widely spread in Asia such as India, Nepal, Malaysia and Indonesia. In Indonesia, this plant widely available in Java precisely Cilegon and Jember area. This study aimed to analyze the content of secondary metabolites from plants kesambi extract and antioxidant activity test of hexane, ethyl acetate and water fraction. Analysis of secondary metabolites is done with phytochemical and GC-MS test methods. Extraction was done by using maceration and fractionation methods. Antioxidan tactivity test using DPPH methods. The content of secondary metabolites contained in leaves kesambi (Schleichera oleosa) are flavonoids, alkaloids, tannins, phenols, and steroids. Based on IC50 values were obtained from three fraction, ethyl acetate fraction had a strong radical inhibition rate than the fraction of water and n-hexane. IC50 fraction of ethyl acetate, water, and n-hexane successively are: 206.0851; 272.2891 and 425,1143 ppm respectively. Keyword: kesambi, schleichera oleosa, DPPH, antioxidant

Antimalarial activity and phitochemical analysis from Suruhan (Peperomia pellucida) extract

JURNAL PENDIDIKAN KIMIA (JPKim) Vol 8, No 3 (2016): Desember 2016
Publisher : JURNAL PENDIDIKAN KIMIA (JPKim)

Show Abstract | Original Source | Check in Google Scholar | Full PDF (565.757 KB)

Abstract

Abstract. Infectious and parasitic diseases is one of various disease that the most common. Based on data from the World Health Organization (WHO) in 2011, infectious and parasitic diseases become the third largest cause of death in the world. One of the plants that have potential as an antimalarial is suruhan (Peperomia pellucida). The purpose of this study is to test antimalarial activity against Plasmodium falciparum and analysis photochemistry consituen from extract suruhan. Antimalarial activity test using Desjardin method. Extraction was done by using maceration wuth methanol as a solvent and fractionation using partition methods. Results of phytochemical screening revealed the presence of alkaloids, flavonoid, steroid, saponins and triterpenoid test results antimalarial activity fraction of n-hexane, ethyl acetate and water show IC50 values are 12.80, 2.90 and 10.74 mg/ mL respectively.Keyword: Peperomia pellucida, suruhan, antimalarial

Antibacterial activity and phytochemical screening of Kesambi (Sapindaceae) against Eschericia coli and Staphylococcus aureus

JURNAL PENDIDIKAN KIMIA Vol 11, No 1 (2019): April 2019
Publisher : JURNAL PENDIDIKAN KIMIA

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Abstract

Kesambi plant (Schleichera oleosa) is a medicinal plant belongs to family Sapindaceae, commonly found in tropical and subtropical regions of the world. In Indonesia, kesambi plants can be found in Java and Bali island. The purpose of this study is to extraction and antibacterial activity test of steam bark extract of kesambi against Escherichia coli and Staphylococcus aureus. Extraction was done by maceration method using n-hexane, ethyl acetate and methanol. Antibacerial test using Kirby bauer method by measure inhibition zone. Phytochemical screening shown that n-hexane extract contain triterpenes and steroid compounds. Ethyl acetate extract contain triterpenes, flavonoid, steroid, and fenolic compounds. Methanol extract contain flavonoid, fenolic and triterpenes compounds. Inhibition zone of n-hexane, ethyl acetate and methanol extracts against E. coli and S. aureus at concentration of  5000 µg/mL showed 4.4; 7.9; 4.6 mm and 4.7; 8.9; 4.5 respectively, while amoxicillin and ciprofloxacin as positive control at concentration of 100 µg/mL showed 6.9 and 7.1 mm respectively. Kesambi extract have potential as antibacterial against E. coli and S. aureus.Keywords:Kesambi; antibacterial; Eschericia coli; Staphylococus aureus

Triterpenoid compound from metanol extract of mangrove leaves (Sonneratia alba) and anti-cholesterol activity test

JURNAL PENDIDIKAN KIMIA Vol 11, No 1 (2019): April 2019
Publisher : JURNAL PENDIDIKAN KIMIA

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Abstract

Mangrove plant (Sonneratia alba) is easily found in West and North Indonesia. Mangrove plant has the potential of being a herb medicine. Mangrove plant variously used in ethnomedicine to treat various deseases like wounds, diarrhea, and fever. In previously sutudy, leaf extract of mangrove plants reported have anti-cholesterol activity. This plant is widely used to treat various deseases like wounds, diarrhea, and fever. The purpose of this study was to isolate triterpenoid compound from the ethyl acetate fraction of mangrove leaves and anticholesterol activity test. Extraction was done by maceration method using methanol 96% as solvent. Isolation was carried out by column chromatography using a combination of n-hexane, ethyl acetate, and methanol solvents. The elucidation of the structure was determined by analysis of IR, 1H-NMR, 13C-NMR, 2D-NMR, and MS spectroscopies as well as by comparisons with the literature. Anticholesterol activity test was carried out in vitro. The results showed that triterpenoid compounds (lupeol) were able to reduce cholesterol from concentrations of 5, 10, 20, 40, 60, and 80 ppm are 13.7; 29.4; 49.0; 60,1; 70.2; and 77.0% respectively. Therefore, isolates compound (lupeol) have anti-cholesterol activity.Keywords:Anti-cholesterol; mangrove; triterpenes