Saleh, Masagus Irsan
Indonesian Pediatric Society

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Correlation of heart failure severity and N-terminal pro-brain natriuretic peptide level in children Mahrani, Yasmien; Nova, Ria; Saleh, Masagus Irsan; Rahadianto, Kemas Yakub
Paediatrica Indonesiana Vol 56 No 6 (2016): November 2016
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi56.6.2016.315-9

Abstract

Background  Heart failure affects morbidity and mortality in children with heart disease. There is no single, specific test to diagnose heart failure. The modified Ross Reithmann scoring system has been used to classify heart failure severity, but it is limited due to its subjectivity. The N-terminal pro-brain natriuretic peptide (NT-proBNP) is secreted by the ventricles during heart failure. It has been suggested as a possible marker for diagnosing heart failure.Objective To investigate the correlation between heart failure severity and plasma NT-proBNP concentration in children aged one month to 14 years.Methods A cross-sectional study was performed in the Pediatrics Department of Mohammad Hoesin Hospital from July to September 2015 on children with congestive heart failure, aged one month to 14 years. Heart failure severity was assesed using the modified Ross Reithmann scoring system. Plasma NT-proBNP measurements were done in all subjects. Statistical analysis was done by Spearman’s test.Results  Subjects’ median plasma NT-proBNP concentration was 1,703 pg/mL (range 310-9,000 pg/mL). The NT-proBNP level and severity of heart failure had a significant, positive correlation (r=0.87; P<0.001). The NT-proBNP minimum levels in subjects with mild, moderate and severe heart failure were 310 pg/mL, 1,251 pg/mL, and 2,610 pg/mL, respectively.Conclusion Plasma NT-proBNP level has a significant, positive correlation with the severity of heart failure in children. As such, NT-proBNP level may be useful as a biochemical marker for the diagnosis and grading of the severity of heart failure in children.
Duration and dose of antiepileptic drugs and serum calcium levels in children Atmasari, Arinta; Dewi, Masayu Rita; Aditiawati, Aditiawati; Saleh, Masagus Irsan
Paediatrica Indonesiana Vol 57 No 2 (2017): March 2017
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi57.2.2017.104-7

Abstract

Background Antiepileptic drugs (AEDs) may affect calcium metabolism through several mechanisms. Much evidence has confirmed that carbamazepine and valproic acid, as the most widely used AEDs in epileptic children, leads to decreased serum calcium levels. This effect was suggested to be time and dose dependent. However, correlations between AEDs and calcium levels in Indonesian epileptic children have not been well studied.Objective To investigate possible correlations between total calcium levels and durations of therapy as well as doses of carbamazepine and valproic acid.Methods This analytical, cross-sectional study was performed from March to May 2015 in the Neuropediatric Outpatient Ward of Mohammad Hoesin Hospital, Palembang, South Sumatera. A total of 60 epileptic children taking carbamazepine and or valproic acid monotherapy were included and grouped accordingly. A single blood test was done for every participant to measure total serum calcium level. Correlation between daily dose or duration of AED with calcium level was assess using the Spearman-rho test.Results The mean total serum calcium levels in the carbamazepine and valproic acid groups were 9.48 (SD 0.83) mg/dL and 9.58 (SD 0.63) mg/dL, respectively. There was a statistically significant moderate correlation between the duration of carbamazepine therapy and total calcium level (r = 0.36; P=0.001). The cut-off point for duration of therapy was 23 months. There were no significant correlations between total calcium level and mean daily carbamazepine dose, nor between total calcium level and duration and dose of valproic acid therapy.Conclusion Longer duration of carbamazepine therapy is associated with low total serum calcium level, but carbamazepine dose is not. In addition, duration and dose of valproic acid are not associated with low total serum calcium level.
Korelasi Paparan Sinar Matahari dengan Derajat Pterigium di Rumah Sakit Khusus Mata Provinsi Sumatera Selatan Periode 2015-2016 Hanifah, Erika sandra nor; Ibrahim, Ibrahim; Saleh, Masagus Irsan
Majalah Kedokteran Sriwijaya Vol 50, No 1 (2018): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Pterigium merupakan pertumbuhan fibrovaskular konjungtiva yang bersifat degeneratif dan invasif. Penyebab kejadian pterigium salah satunya adalah sinar ultraviolet (UV) baik UVA maupun UVB. Berdasarkan ukurannya pterigium sendiri dikelompokkan menjadi 4 ukuran, yaitu derajat 1,2,3,dan 4. Penelitian ini bertujuan untuk mengetahui adanya korelasi antara derajat pterigium dan paparan sinar matahari di RSKM provinsi Sumatera Selatan. Penelitian ini merupakan penelitian deskriptif korelatif dengan menggunakan rancangan serial kasus (case series). Sampel penelitian ini adalah rekam medik penderita pterigium di RSKM provinsi Sumatera Selatan 2015-2016 sebanyak 40 sampel minimal. Dari 40 subjek penelitian mayoritas (39,7%) didiagnosis sebagai pterigium derajat IV, diikuti berturut-turut pterigium derajat III (31%), pterigium derajat II (25,9%), dan pterigium derajat I (3,4%). Terdapat korelasi yang kuat antara derajat pterigium dan lama paparan sinar matahari sejak 10 tahun yang lalu (p value=.0,018, r=0,458). Pada korelasi antara derajat pterigium dengan lama paparan sinar matahari sejak 5 tahun yang lalu tidak ditemukan adanya korelasi (p value=0,072).