Agustiningsih, Denny
Department of Physiology Faculty of Medicine Universitas Gadjah Mada

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The Influence of Dry Cupping toward Heart Rate Variability (HRV) in Male Obesity adolescence Syahruramdhani, Syahruramdhani; Agustiningsih, Denny; Sofro, Zaenal Muttaqien
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 16 No 2: July 2016
Publisher : Universitas Muhammadiyah Yogyakarta

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Abstract

Cardiovascular disease defines as a disease related to heart and blood vessel. One of high risk in the disease of cardiovascular is its on people with obesity. Heart Rate Variability (HRV) indicator is an important sign to identify cardiovascular risk and provide early information related to change of heart autonomy controlling. This indicator was influenced by several factors such as cupping therapy. Study found that HRV increased after cupping therapy by wet cupping treatment in healthy people. The aims of this research is to investigate the influence of dry cupping toward increased HRV in male obesity adolescence. The study was experimental with pre-post test design by using consecutive sampling of 30 male adolescence aged 18-24 years old with BMI  25 kg/m2. They were divided into 2 groups, control and intervention group with cupping therapy. Data result used in SDDN and RMSSD level. Analysis Data were used paired and independent t test. The result showed SDNN and RMMSD level before intervention were 73,95 ms dan 67,11 ms. Whereas SDNN and RMMSD level after intervention were 69,66 ms dan 61,95 ms. In paired (p=0,52 and p=0,38) and independent t test (p=0,30 and p=0,56) showed that there were no significant difference between SDNN and RMSSD in intervention group and control group (p>0,05). The conclusion of this study is dry cupping had no effects toward increased HRV level in male obesity adolescence.
The Influence of Dry Cupping toward Heart Rate Variability (HRV) in Male Obesity adolescence Syahruramdhani, Syahruramdhani; Agustiningsih, Denny; Sofro, Zaenal Muttaqien
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 16 No 2: July 2016
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (47.922 KB)

Abstract

Cardiovascular disease defines as a disease related to heart and blood vessel. One of high risk in the disease of cardiovascular is its on people with obesity. Heart Rate Variability (HRV) indicator is an important sign to identify cardiovascular risk and provide early information related to change of heart autonomy controlling. This indicator was influenced by several factors such as cupping therapy. Study found that HRV increased after cupping therapy by wet cupping treatment in healthy people. The aims of this research is to investigate the influence of dry cupping toward increased HRV in male obesity adolescence. The study was experimental with pre-post test design by using consecutive sampling of 30 male adolescence aged 18-24 years old with BMI 25 kg/m2. They were divided into 2 groups, control and intervention group with cupping therapy. Data result used in SDDN and RMSSD level. Analysis Data were used paired and independent t test. The result showed SDNN and RMMSD level before intervention were 73,95 ms dan 67,11 ms. Whereas SDNN and RMMSD level after intervention were 69,66 ms dan 61,95 ms. In paired (p=0,52 and p=0,38) and independent t test (p=0,30 and p=0,56) showed that there were no significant difference between SDNN and RMSSD in intervention group and control group (p>0,05). The conclusion of this study is dry cupping had no effects toward increased HRV level in male obesity adolescence.
Gambaran Faktor Risiko Prolaps Organ Panggul Pasca Persalinan Vaginal di Daerah Istimewa Yogyakarta Pangastuti, Nuring; Sari, Dwi Cahyani Ratna; Santoso, Budi Iman; Agustiningsih, Denny; Emilia, Ova
Majalah Kedokteran Bandung Vol 50, No 2 (2018)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v50n2.1321

Abstract

Prolaps organ panggul merupakan salah satu bentuk disfungsi dasar panggul pada perempuan. Disfungsi dasar panggul adalah keadaan terganggunya fungsi dasar panggul merupakan salah satu kondisi kesehatan yang banyak dikeluhkan perempuan. Lebih dari 46% perempuan dengan riwayat persalinan vaginal mengalami disfungsi dasar panggul,dan peningkatan jumlah paritas berkorelasi dengan peningkatan kejadian prolaps organ panggul. Tujuan penelitian ini adalah untuk mengetahui gambaran karakteristik faktor risiko prolaps organ panggul pasca persalinan vaginal di wilayah Daerah Istimewa Yogyakarta. Penelitian dilakukan pada Januari–Maret 2018. Hasil penelitian didapatkan 51 subjek penelitian dengan persalinan vaginal yang dapat dilakukan pemeriksaan POPQ pada 3 bulan pascapersalinan. Prolaps organ panggul didapatkan pada sebagian besar pasien pascasalin, yaitu sejumlah 46 orang, prolaps uteri 33 orang, sistokel 44 orang, serta rektokel pada 46) orang. Hanya 5 orang yang tidak memiliki gambaran prolaps organ panggul pada 3 bulan pascapersalinan.Dari penelitian ini dapat disimpulkan bahwa faktor risiko prolaps organ panggul pascapersalinan vaginal di Daerah Istimewa Yogyakarta terdiri atas faktor intrinsik (usia ibu, panjang genital hiatus maupun perineal body), dan ekstrinsik (paritas, indeks massa tubuh overweight dan obes, kenaikan berat badan selama hamil >15 kg, serta dilakukan episiotomi dan terjadi robekan perineum). Upaya pencegahan terutama edukasi, perbaikan gaya hidup, pengendalian indeks massa tubuh, pengaturan diet, olahraga penguatan otot dasar panggul, pembatasan jumlah kehamilan dan persalinan, serta pertolongan persalinan sesuai Asuhan persalinan normal. Kata kunci: Disfungsi dasar panggul, faktor risiko, persalinan vaginal, prolaps organ panggul Risk Factors for Pelvic Organ Prolapse in Women with History of Vaginal Delivery in YogyakartaPelvic organ prolapse is one form of pelvic floor dysfunctions in women that impairs the pelvic floor function and also one of the most frequently conditions complained by women. More than 46% women with history of vaginal delivery have experienced pelvic floor dysfunction where higher number of parity correllates to increased pelvic organ prolapse incident. The aim of this study was to understand the  characteristic risk factors of pelvic organ prolapse incident post vaginal delivery in Special Region of Yogyakarta. The study ws performed during the period of January to March 2018 on 51 subjects with history of vaginal delivery evaluated using POPQ in 3 months postpartum. Pelvic floor dysfunction was present in most postpartum patients, i,e, 46 people while 33 experienced uterine prolapse, 44 experienced cystocele, and 46 experienced rectocele. Only 5 subjects had no pelvic floor dysfunction in any form. Risk factors for pelvic organ prolapse in post vaginal delivery in the Special Region of Yogyakarta consist of intrinsic factors (maternal age, genital length of hiatus, and perineal body), and extrinsic factors (parity, overweight status and obese status based on body mass index, weight gain during pregnancy exceeding 15 kg,  episiotomy and the occurrence of perineal rupture). Prevention actions include  education followed by lifestyle improvement, control of body mass index, dietary regulation, exercise, restrictions on the number of pregnancies and childbirth, and safe delivery according to normal birth care standard.Key words: Pelvic floor dysfunction, pelvic organ prolapse, risk factors, vaginal delivery
PENGARUH LATIHAN RENANG TERHADAP KADAR HORMON KORTISOL PADA PENDERITA ASMA Handayani, Rahmaya Nova; Agustiningsih, Denny; Djuneadi, Achmad
Viva Medika Vol 7 No 1 (2014)
Publisher : Universitas Harapan Bangsa Purwokerto

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Bronchial asthma is one of allergic disease and a health problem both in developedcountries and in developing countries characterized by reversible narrowing of the bronchi due tobronchial hyperactivity . The prevalence and hospitalization rates of bronchial asthma indeveloped countries from year to year tend to increase. One of the triggers of asthma is stress.Stress is closely related to a hormone called glucocorticoids . Glucocorticoids which regulatesmetabolism and resistance to stress , including cortisol , corticosterone and cortisone .Glucocorticoids can potentially respond kotekolamin the bronchial tissue , occurs only atconcentrations influence physiology . This suggests cortisol has a role in affecting airway tone in individuals.The purpose of this study was mengidentifikasipengaruh swimming against cortisol levels in patients with asthmaThe design of this study is a quasi experimental study with pre-post study design -test group design . Measurement of cortisol levels do in the beginning , middle and end of thetreatment pool exercises were performed 1 week 3 times in the morning with a sample of 20respondents . Cortsisol hormonal measurements done using ELIZA measurement , the blood of therespondents were taken before and after swimming practice . People with asthma are taken by amedical diagnosis is determined by the doctor at the health center Brits with the male genderThe result of this research is there before and after the effect of swimming exercise on cortisollevels in patients with asthma . Keywords : Pool , cortisol , asthma
PENGARUH SENAM ASMA TERHADAP PENINGKATAN FORCED EXPIRATORY IN 1 SECOND (FEV 1) PADA PENDERITA ASMA Handayani, Rahmaya Nova; Agustiningsih, Denny; Djuneadi, Achmad
Viva Medika Vol 7 No 2 (2014)
Publisher : Universitas Harapan Bangsa Purwokerto

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Asthma is a disorder such as chronic inflammation of the airways that causes hyperactivity of thebronchi to various stimuli which is characterized by symptoms of recurrent episodic form of wheezing , coughing , shortness of breath and tightness in the chest , especially at night or earlymorning are generally reversible either with or without treatment. Asthma fluctuated ( intermittent) means it can be quiet without symptoms , but can not interfere with the activities developed mildto severe symptoms can even cause death . One indication of obstruction in the respiratory tract isForced expiratory volume in 1 second ( FEV1 ) decreased . Forced expiratory volume in 1 secondis the amount of air that is expelled as soon as possible in the first second after taking the deepest breath. The purpose of this study was to determine the effect of asthma gymnastics to increasedFEV1 in patients with asthma . The design of this study is a quasi experimental study with pre-post study design -test group design . FEV1 measurements made at the beginning , middle and endof the treatment of asthma gymnastics performed 1 week 3 times in the morning with a sample of20 respondents . Gymnastics asthma conducted every Tuesday , Thursday and Saturday at 07.00 pm for 12 weeks . FEV1 measurements done using sprirometri brand " Autospiro AS - 505 "Minato Japanese production . People with asthma are taken by a medical diagnosis is determined by thedoctor at the health center Brits with the male gender .The result of this study is therebefore and after the effect of asthma gymnastics to increased FEV1 in patients with asthma . Keywords : Gymnastics asthma , FEV1 , asthma
Efek Sitotoksik Madu Dan Silver Dressing Terhadap Sel Fibroblas Dalam Media Tinggi Glukosa: Studi In Vitro Rizqi, Januar; Agustiningsih, Denny; Agung, Dwi Aris; Arfian, Nur
Jurnal Keperawatan Respati Yogyakarta Vol 6, No 2 (2019): Mei 2019
Publisher : Universitas Respati Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.2016/jkry.v6i2.316

Abstract

Penyembuhan luka diabetes merupakan proses yang unik dan kompleks. Sejumlah dressing dikembangkan untuk mengetahui manfaat yang diharapkan meningkatkatkan proses penyembuhan. Penelitian in vivo maupun in vitro madu dan silver menunjukan hasil yang berbeda. Diperlukan penelitian lebih lanjut aktifitas sitotoksik madu dan silver terhadap sel fibroblas dalam media tinggi glukosa. Penelitian inibertujuan untuk mengetahui apakah madu dan silver bersifat sitotoksik terhadap sel fibroblast dalam media tinggi glukosa. Jenis penelitian ini adalah kuasi eksperimental  dengan post test only desain. Kultur sel fibroblast di uji sitotoksik dengan meggunakan metode MTT Assay secara in vitro. Kelompok penelitian dibagi menjadi  kelompok madu dengan konsentrasi 6%, 3% 1.5% dan kelompok Silver. Silver memiliki efek sitotoksik terhadap sel fibroblas dengan nilai penghambatan sebesar 100%. Madu dengan konsentrasi 6% dan 3% memiliki nilai penghambatan lebih dari 50%. Madu konsentrasi 1,5% menujukan proses penghambatan kurang dari 50% dan meningkatkan proses priliferasi sel fibroblas dalam media tinggi glukosa. Madu memiliki aktifitas sitotoksik yang lemah terhadap sel fibroblas dan dapat meningkatkan proliferasi sel, sedangkan silver memiliki aktifitas sitotoksik yang kuat terhadap sel fibroblast.
ALOE VERA STIMULATES CELL PROLIFERATION, CELL MIGRATION, EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR-A (VEGF-A), AND C-JUN N-TERMINAL KINASE-1 (JNK-1) ON FIBROBLAST CELL CULTURED OF DIABETIC RAT SKIN Firdaus, Insanul; Arfian, Nur; Wahyuningsih, Mae Sri Hartati; Agustiningsih, Denny
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 51, No 2 (2019)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

ABSTRACTBackground: Delayed healing process in diabetic wound caused by the disturbance of cell migration and cell proliferation, also diminished production of VEGF and JNK-1 which are important factors in wound healing process. Aloe vera contains variety of active compounds which can help in wound healing process. The research assess the effect of ethanol extract from A. vera in fibroblast cell cultures of diabetic rat skin by investigating of cell proliferation, cell migration, VEGF-A and JNK-1 expression.Method: Experimental research by using primary skin fibroblast cell culture of diabetic Wistar rat. The samples were given A. vera extract with concentration 500, 250, and 125 µg/mL. The proliferation examination carried out by counting the number of cells, in vitro scratch assay method was used to monitor the cell migration, and RT-PCR was used to VEGF-A and JNK-1 expression examination.Result: Cell proliferation examination in 24 and 48 hour, the AV500 and AV250 group had higher number of cells than negative control group, but there was no significant difference (p>0.05). However the examination in hour 72 had significant difference between AV500 group (29.33±1.28x104 cells/mL) and negative control group (22.91±3.21x104 cells/mL) (p=0.14). The examination of cell migration in 24 hours, the AV500, AV250 and AV125 group had higher percentage of cell migration (78.13±7.18%; 73.88±4.75%; 68.80±17.11%) than negative control group (53.91±2.74%) (p=0.003; p=0.009; and p=0.040). In contrast, examination in 48 and 72 hour had no significant difference (p>0.05). The expression of VEGF-A and JNK-1 in 48 hours, the AV500 group had higher than negative control group (p=0.001 and p=0.003).Conclusion: A.vera has effect to increase cell proliferation, cell migration, VEGF-A and JNK-1 expression in fibroblast cell culture of diabetic rat skin.