Found 2 Documents


Journal of Research and Technology Vol 3, No 1 (2017)
Publisher : Universitas Nahdlatul Ulama Sidoarjo

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Today, microwave can be used in various chemical processes. The advantage of microwaves is able to deliver energy directly to the material. One of microwave application is the extraction process of natural materials. Microwaves can be used to reduce extraction process time of the anthocyanin from the dragon fruit skin. This research aims to determine the solvent extracted effect to the anthocyanin extraction of dragon fruit skin using microwaves. The solvent used was 95% ethanol, 85% ethanol, 75% ethanol, 95% ethanol –citric acid, 85% ethanol -acids and 75% - citric acid ethanol to the anthocyanin extraction results of dragon fruit skin extracted using microwaves. The consumption of microwave power is 400 watt with 50 gram of dragon fruits skin. Then, anthocyanin extracts are mixe with supporting materials to be made as lipstick and proposed for topical and favorite test. The best yield can be obtained by using ethanol-citric acid solvent at 25,031%.

Anti-inflammatory Activity of Pharmaceutical Gel of Ethanolic Extract from Marine Sponge Xestospongia Sp

Borneo Journal of Pharmacy Vol 2 No 1 (2019): Borneo Journal of Pharmacy
Publisher : ?Institute for Researches and Community Services Universitas Muhammadiyah Palangkaraya

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The aim of this study was to determine the characteristics of the gel formula based on it’s organoleptic properties, pH, viscosity, dispersion and homogenity by stability test carried out using the cycling test method and to determine the anti-inflammatory activity of the Xestospongia Sp. in male white mice (Mus musculus) by creating an artificial edema on the mice left foot induced by 1% λ-carrageenan. The gel formula from the ethanol extract of Xestospongia Sp. sponge was physically stable in terms of its organoleptic observation, homogenity, pH and viscosity test. However, the results that were obtained after dispersion test did not fulfill the requirements. In this study, the gel formula of the ethanol extract of Xestospongia Sp. sponge was administered on the mice left foot by using the variations in extract concentration of 0.02%, 0.03%, and 0.04%, and the gel without extract as a negative control and Galtaren®gel (1% Diclofenac Sodium) as a positive control. The evaluated data were in the form of mice leg edema volume measured based on its percent of inflammation and percent of inflammatory inhibition and observed for 360 minutes. The data were analyzed by using the Kruskal-Wallis test followed by the Mann-Whitney test with a confidence level of 95%. The results of this study showed that the gel formula of ethanol extract of Xestospongia Sp. sponge has an anti-inflammatory effect on each concentration and the formula that has a large anti-inflammatory effect was obtained at extract concentration of 0.04%.