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Gastric Ulcer Healing Effect of Bangle (Zingiber cassumunar (Roxb.)) Rhizome Extract in Aspirin-induced Rats Model Yuniarto, Ari; Susilawati, Elis; Rahman, Toni Abdul; Setiawan, Finna; Juanda, Dadang
Indonesian Journal of Pharmaceutical Science and Technology Supp 1, No 1 (2017)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (481.322 KB) | DOI: 10.15416/ijpst.v1i1.10436

Abstract

In the gastrointestinal system, gastric ulcers are one of the common serious diseases. The pathophysiology of gastric ulcer is an imbalance between aggressive and mucosal defense factor. Imbalance between aggressive and mucosal defense factor have contribution against developed of gastric ulcer disease. The objective of the research was to evaluate gastric ulcer healing effect of Bangle (Zingiber cassumunar (Roxb.) rhizome extract in aspirin-induced rats model. Antiulcer activity of Bangle rhizome extract was evaluated by several parameters involving gastric acidity, number of ulcers, diameters of ulcers, ulcer index, and healing ratio. Doses level of Bangle rhizome extract which used in this study such as 50 mg/kg and 100 mg/kg, respectively. Histopathological of the stomach was performed using hematoxylin-eosin stained. The results of study showed that groups which given Bangle rhizome extract have signi cant effect in gastric acidity, number of ulcers, diameters of ulcers, ulcer index, and healing ratio compared to the control group. Histopathological study of the stomach ulcers showed tissues regeneration in group were treated by Bangle rhizome extract compared to the control group. It can be concluded that from the experimental study of Bangle (Zingiber cassumunar (Roxb.)) rhizome extract have potential antiulcer activity in aspirin-induced rats model. Keywords : Zingiber cassumunar (Roxb.), Extract, Ulcer, Aspirin. 
Desa Mitra dalam Budidaya Tanaman Obat Keluarga Menuju Desa Cibiru Wetan sebagai Sentra Herbal Muttaqin, Fauzan Zein; Aligita, Widhya; Muhsinin, Soni; Juanda, Dadang; Asnawi, Aiyi
Jurnal Pengabdian Pada Masyarakat Vol 3 No 2 (2018)
Publisher : Universitas Mathla'ul Anwar Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (650.779 KB) | DOI: 10.30653/002.201832.59

Abstract

PARTNER VILLAGE IN FAMILY MEDICINE PLANT CULTIVATION TOWARDS CIBIRU WETAN VILLAGE AS A HERBAL CENTER. The area of ​​Cibiru Wetan Village is a farming area because besides the limited water supply, the land is hilly. With the initiative and participation of women farmer groups which had so many achievements and skills, it was necessary to explore the potential that could provide a new icon for Cibiru Wetan Village. The purpose of the activity was to socialize and practice the cultivating of the medicinal plants carried out by a group of women farmers with simple and effective technology and finally able to become a center of dried herbs production. The method used in the cultivation program for medicinal plants was divided into three stages. The first stage was to provide material counseling on family medicinal plants including the understanding of the benefits of the plant, the second stage was to provide an explanation or training in planting family medicinal plants and the last stage or third stage was to practice directly in planting these medicinal plants. The results showed a positive understanding of both groups for both the socialization and counseling stages as well as for the practice of medicinal plants cultivation. It could be concluded, the partner village activities in medicinal plants cultivation could improve the understanding of the target group.
Penetapan Kadar Total Fenol dan Aktivitas Antioksidan dari Jus Buah Lima Spesies Jeruk (Citrus sp.) Juanda, Dadang
JURNAL FARMASI GALENIKA Vol 2 No 01 (2015): JURNAL FARMASI GALENIKA
Publisher : Sekolah Tinggi Farmasi Bandung

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Abstract

Jeruk merupakan buah yang sering dikonsumsi oleh masyarakat Indonesia, jenis jeruk cukup banyak diantaranya jeruk sunkist (Citrus sinensis Osbeck), jeruk purut (Citrus hystrix D. C.), jeruk nipis (Citrus aurantifolia), jeruk bali (Citrus maxima Merr) dan jeruk garut (Citrus nobilis Lour), kandungan senyawa aktif yang diketahui cukup banyak diantaranya senyawa fenolat yang diketahui memiliki aktivitas sebagai antioksidan. Penelitian ini dilakukan untuk menetapkan kadar senyawa fenol dan aktivitas antioksidan dari dari beberapa spesies jeruk. Buah jeruk diblender  dan filtrat yang diperoleh  di freeze dry sehingga didapat jus kering. Jus jeruk ditentukan kadar total fenol dengan menggunakan reagen Folin Ciocalteau dan aktivitas antioksidan diuji secara in vitro menggunakan metode peredaman radikal bebas DPPH (1,1-difenil-2-pikrilhidrazil). Kadar fenol total  dari jeruk sunkist, jeruk purut, jeruk nipis, jeruk bali dan jeruk garut secara berurutan  98,6 ; 141,7; 81,7; 71,3; 67,4 (mg asam galat/100 g jus). Aktivitas antioksidan dari jeruk sunkist, jeruk purut, jeruk nipis, jeruk bali dan jeruk garut  memberikan EC50 (Efisien Konsentrasi) secara berurutan 732,00; 1.255,07; 1.631,80;  1.739,72; 2.192,2 µg/mL..