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Evaluasi Rasionalitas Penggunaan Obat ditinjau dari Indikator Peresepan World Health Organization (WHO) Pasien Rawat Jalan Poli Penyakit Dalam Periode Januari-Juni 2015 di Rumah Sakit Umum Bahteramas Provinsi Sulawesi Tenggara Hamsidi, Rini; Fristiohady, Adryan; Musabar, Nasyrah
Pharmauho Vol 1, No 2 (2015): Pharmauho
Publisher : Pharmauho

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Abstract

On 1993, prescribing in Indonesia was still irrational. It can be seen from many pharmacy (3,5/patient), overuse of antibiotics (43%), and inappropriate overuse of injections (10-80%). This study aimed to evaluate rationality of drugs use based on prescribing indicators by WHO of outpatient in poly interna medicine at Bahteramas general hospital of Southeast Sulawesi from January to June period of 2015 and analyze significant differences of each month. Method of this study was retrospective and concurrent. Total amount of sample were 600 recipes. Technic of sampling was simple randomized sampling. Results of the study compared with WHO standards on 1993. Analyze significant differences of each month of this study was SPSS 16.0 with Kruskal Wallis method. Results of this study showed that average drug prescribed was 3; average percentage of medicines prescribed by generic name was 85.39%; average percentage encounters with antibiotic prescribed was 36%; average percentage encounters with injection prescribed 0%; and average percentage of medicines prescribed from Formulary of Hospital 99.81%. Result show that drug use at Bahteramas general hospitals each monthof outpatient poly interna period January-June 2015 there was no difference (p ≥ 0.05)Keywords: rational,  interna, Bahteramas, recipes, WHO
Evaluasi Penggunaan Obat Antituberkulosis pada Pasien TB Paru di Rumah Sakit Umum Bahteramas Provinsi Sulawesi Tenggara Fristiohady, Adryan; Ihsan, Sunandar; Haringi, Elfira
Pharmauho Vol 1, No 1 (2015): Pharmauho
Publisher : Pharmauho

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Abstract

TB merupakan penyakit menular yang saat ini masih menjadi permasalahan di dunia kesehatan. TB adalah penyakit menular yang disebabkan oleh infeksi Mycobacterium tuberculosis. Permasalahan TB semakin memburuk dengan meningkatnya jumlah penderita yang tidak berhasil disembuhkan. Tingginya angka kejadian TB disebabkan oleh ketidakpatuhan terhadap program pengobatan maupun penggunaan paduan obat anti tuberculosis (OAT) yang tidak sesuai. Tujuan dari penelitian ini adalah untuk mengevaluasi penggunaan obat anti tuberkulosis pada pasien TB paru meliputi kesesuaian penggunaan paduan OAT dan kesesuaian dosis. Penelitian ini dilakukan menggunakan metode retrospektif dan dianalisis secara deskriptif non analitik dari data rekam medik. Pengambilan sampel dilakukan secara simple random sampling dengan jumlah sampel sebanyak 61 pasien. Hasil penelitian menunjukkan bahwa dari 61 pasien diperoleh persentase pola penggunaan OAT berdasarkan tipe pasien terbanyak pada tipe pasien kasus baru yaitu 96,8%, pola penggunaan OAT berdasarkan kategori pengobatan terbanyak pada kategori 1 yaitu 96,8% dan pola penggunaan OAT berdasarkan jenis OAT terbanyak pada OAT sediaan tunggal (kombipak) yaitu 67,2%. Berdasarkan kesesuaian paduan OAT diperoleh persentase 96,8% dan ketidaksesuaian  paduan sebesar 3,2%. Sedangkan persentase kesesuaian dosis adalah 32,8%. Kata kunci: TB Paru, OAT, Sulawesi Tenggara, Mycobacterium tuberculosis 
Anti-inflammatory Activity of Pharmaceutical Gel of Ethanolic Extract from Marine Sponge Xestospongia Sp Zubaydah, Wa Ode Sitti; Wahyuni, Wahyuni; Sahidin, Sahidin; Halik, Tian Amalia; Andriani, Rina; Indalifiany, Astrid; Fristiohady, Adryan
Borneo Journal of Pharmacy Vol 2 No 1 (2019): Borneo Journal of Pharmacy
Publisher : ?Institute for Researches and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v2i1.694

Abstract

The aim of this study was to determine the characteristics of the gel formula based on it’s organoleptic properties, pH, viscosity, dispersion and homogenity by stability test carried out using the cycling test method and to determine the anti-inflammatory activity of the Xestospongia Sp. in male white mice (Mus musculus) by creating an artificial edema on the mice left foot induced by 1% λ-carrageenan. The gel formula from the ethanol extract of Xestospongia Sp. sponge was physically stable in terms of its organoleptic observation, homogenity, pH and viscosity test. However, the results that were obtained after dispersion test did not fulfill the requirements. In this study, the gel formula of the ethanol extract of Xestospongia Sp. sponge was administered on the mice left foot by using the variations in extract concentration of 0.02%, 0.03%, and 0.04%, and the gel without extract as a negative control and Galtaren®gel (1% Diclofenac Sodium) as a positive control. The evaluated data were in the form of mice leg edema volume measured based on its percent of inflammation and percent of inflammatory inhibition and observed for 360 minutes. The data were analyzed by using the Kruskal-Wallis test followed by the Mann-Whitney test with a confidence level of 95%. The results of this study showed that the gel formula of ethanol extract of Xestospongia Sp. sponge has an anti-inflammatory effect on each concentration and the formula that has a large anti-inflammatory effect was obtained at extract concentration of 0.04%.