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UJI AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL DAUN PISANG AMBON (Musa paradisiaca L.) TERHADAP TIKUS PUTIH (Rattus norvegicus L.) YANG DIINDUKSI KARAGENAN Sukmawati, Sukmawati; Yuliet, Yuliet; Hardani, Ririen
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Vol 1, No 2 (2015): (October 2015)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (435.735 KB) | DOI: 10.22487/j24428744.2015.v1.i2.6244

Abstract

Anti-inflammatory activity test of ethanolic extract of banana leaf (Musa Paradisiaca L.) on carrageenan-induced paw edema in white male rats (Rattus novergicus L.) has been conducted. It was aimed to investigate and to determine the anti-inflammatory activity and its effective dose. The extract was prepared by maceration method using ethanol 96%. Anti-inflammatory activity test was performed in five different groups. Each group consisted of 5 rats. The 1st group (negative control) was given 0.5% CMC-Na suspension; the 2nd group (positive control) was given diclofenac sodium 9 mg/KgBW; the 3rd, 4th, and 5th groups were successively given the banana leaf extract as much as 500, 750 and 1000 mg/KgBW. Each rat was then induced by 1% carrageenan and tested using subplantar method.  The inflamed paw diameter was measured using a calliper while the inflamed paw volume using pletysmometer. The measurements were done for 6 hours long with intervals of 60 minutes. The data was statistically analyzed using ANOVA (analysis of variance). The results showed that the negative control had a significant difference with the other treatment groups which did not show any anti-inflammatory effect. In conclusion, ethanolic extract of banana leaf has effective anti-inflammatory activity at a dose of 750 mg/KgBW
POTENSI EFEK HIPOGLIKEMIK KOMBINASI EKSTRAK ETANOL UMBI BAWANG HUTAN (Eleutherine bulbosa) DAN KULIT BATANG KAYU MANIS (Cinnamomum burmanii) PADA TIKUS (Rattus norvegicus) DIABETES YANG DIINDUKSI STREPTOZOTOSIN DAN TOLERANSI GLUKOSA Prabaningsih, Devyayu; Yuliet, Yuliet; Hardani, Ririen
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Vol 2, No 1 (2016): (March 2016)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (166.037 KB) | DOI: 10.22487/j24428744.2016.v2.i1.5225

Abstract

Research on potential hypoglycemic effects of ethanol extract combination of onion forest bulbs (Eleutherine bulbosa) and burmani cortex (Cinnamomum burmanii) in streptozotocin (STZ)-induced diabetic and glucose tolerant rats (Rattus norvegicus) has been conducted. This study aimed to determine the hypoglycemic effect and the effective dose of ethanol extract combination of forest onion bulbs and cinnamon cortex. Extract was obtained by maceration using 96% ethanol. A number of 30 male rats were divided into 6 groups and each group consisted of 5 rats. The first group (negative control) was given Na.CMC; the second group (positive control 1) glibenclamide 0.45 mg/kgBW; the third group (positive control 2) acarbose 9 mg/kgBW; while the 4th, 5th, and 6th were successively given combination of ethanol extract of forest onion bulbs and cinnamon cortex at doses of 100+100, 50+50, and 25+25 mg/kgBW. Each rat group was intraperitoneally (ip) induced with STZ 40 mg/kgBW and then treated for 14 days, after the rats developed diabetic condition, glucose tolerance test was performed with the induction of sucrose 150mg/kgBW which was continued with observation in minute 60, 90, 120, 150, and 180. Treatment data were analyzed using ANOVA (analysis of variance) with 95% confidence interval. The results showed that ethanol extract combination of forest onion bulbs and cinnamon cortex had potential hypoglycemic effects in male rats of which the most effective combination dose was at a dose of 50 + 50 mg/kgBW
PENGARUH ION KROMIUM(III) PADA EKSTRAKSI ION TEMBAGA(II) MENGGUNAKAN EMULSI KEROSEN DENGAN 1-FENIL-3-METIL-4-BENZOIL-5-PIRAZOLON SEBAGAI PEMBAWA KATION Hamzah, Baharuddin; Said, Irwan; Hardani, Ririen
Jurnal Akademika Kimia Vol 2, No 3 (2013)
Publisher : Universitas Tadulako

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Abstract

The influence of chromium(III) ion on copper(II) ion extraction using kerosene emulsion with 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone (HPMBP) as a cation carrier was investigated. The optimum condition for copper(II) extraction were as follows: concentration of mixed surfactant (span 80+span 20) was 5%, volume ratio of kerosene and internal phase was 1, concentration of HPMBP was 0.025 M, concentration of HCl was 1 M, volume ratio of emulsion and external phase was 0.143. The results showed that the extraction of copper(II) ion was selective to chromium(III) ion, relatively. The result also showed that the presence of 500 ppm chromium(III) ion decrease the percentage of copper(II) ion extraction from 98.6 to 91.0.
FORMULASI MIKROEMULSI EKSTRAK TERPURIFIKASI DAUN BAYAM MERAH (Amaranthus tricolor L.) SEBAGAI SUPLEMEN ANTIOKSIDAN Handayani, Dwi Lestari; Yusriadi, Yusriadi; Hardani, Ririen
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Vol 3, No 1 (2017): (March 2017)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (182.11 KB) | DOI: 10.22487/j24428744.2017.v3.i1.8133

Abstract

A research has conducted about the microemulsion formulation of purified extract of red spinach leaves (Amaranthus tricolor L.) as an antioxidant supplement with the aim to be able to know the formula to form a microemulsion which meet the physical quality stability and determine antioxidant activity (IC50) of the preparation. Extracts prepared by maceration method using ethanol 96% and then later do the purification using solvent n-hexane and ethyl acetate, after it tested its antioxidant activity. Formula to form a microemulsion purified extract of red spinach leaves clear is to use virgin coconut oil (VCO) by 15%, tween 80 for 40%, 35% glycerin and 10% distilled water. Physical stability test was conducted on the organoleptic test, measuring the diameter of globules, pH test, test and test viscosity centrifugation. Test of antioxidant activity in vitro using DPPH method and using Vitamin C as a positive control. Measurement data were statistically analyzed using paired samples T test. The test results of antioxidant activity microemulsion purified extracts of spinach leaves, red show IC50 values on day 1 was 1.83 ppm and the 28th day amounted to 3.71 ppm. While vitamin C microemulsion shows IC50 values on day 1 of 0.24 ppm and the 28th day of 2.51 ppm. Despite the decreased antioxidant activity, but each of the stocks included in the category of very powerful antioxidants.