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Association between hepatitis C infection and number of screened blood unit transfusions in thalassemic children

Paediatrica Indonesiana Vol 45 No 4 (2005): July 2005
Publisher : Indonesian Pediatric Society

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Abstract

Background Donor blood screening test for antibody againsthepatitis C virus (HCV) by third generation ELISA is widely used.However, there is still a window period during which a donor mayalready be infected despite a negative screening test.Objectives To determine the prevalence of hepatitis C infection inthalassemic children who had received screened donor blood andto seek the association between HCV infection and the number ofblood unit transfusions received.Methods This was an analytic cross-sectional study. Sixty-sevenchildren who had received third generation ELISA screened donorblood were examined for HCV antibody. The study was conductedin Hasan Sadikin General Hospital, Bandung, from January toMarch 2004. The prevalence of hepatitis C was presented in per-centage. The association between HCV infection and sex, age,interval between transfusions, and the number of blood unit trans-fusions received was determined by univariate analysis and logis-tic regression analysis.Results In univariate analysis, significant difference between HCV-infected and uninfected subjects was found in the mean age andmean number of blood units transfused (P<0.001). In logistic re-gression analysis, we found a significant association between thequantity of transfused blood with positive HCV antibody (P<0.001).The odds ratio for positive HCV antibody was 1.08 for each bloodunit transfusion received (95%CI 1.02;1.14). The prevalence ofhepatitis C in thalassemic children who received third generationELISA screened blood was 22.4% (95%CI 12.4%;32.4%). Thisprevalence is lower than that in a previous study of thalassemicchildren receiving unscreened blood (50.8%).Conclusions The prevalence of HCV infection in thalassemic chil-dren who had received screened donor blood is 22.4%. HCV in-fection is significantly associated with the number of screened bloodunit transfusions

Prevalence of HBsAg positive among non- immunized junior high school students in Bandung

Paediatrica Indonesiana Vol 47 No 6 (2007): November 2007
Publisher : Indonesian Pediatric Society

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Abstract

Background Sero-epidemiologic survey of hepatitis B is used todetermine the prevalence of hepatitis B infection in community,particularly among population which has not been covered byhepatitis B immunization program.Objective To determine the prevalence of HBsAg positive amongjunior high school’s students in Bandung.Methods A cross-sectional study was conducted on junior high school(SMP) students. Subjects were selected randomly using stratifiedcluster sampling of 4 junior high schools in Bandung. The inclusioncriteria were students of first and second grade, lived in Bandungarea, without history of hepatitis B immunization. Subjects wereinterviewed and were screened for HBsAg using Reverse PassiveHemagglutination technique.Results There were 341 subjects consisted of 201 girls and 140boys. None of the subjects had any sexual intercourse or intravenousdrugs, while 261 subjects (76.5%) had shared personal care. Historyof blood transfusion was found in 13 subjects (3.8%), tattooing in2 (3.8%), body piercing in 28 (8.2%), and contact with chronicliver disease patients in 16 (4.7%). Based on HBsAg serologic test,3 subjects (2 boys and 1 girl) were found to be positive, thus HBsAgpositive prevalence was 0.9% (95%CI -0.001;0.019). Two of themhad shared personal care with their relatives or friends. None ofthem had tattoo, body pierce, blood transfusion, or contact withchronic liver disease patients. Their physical condition were withinnormal limit. One of them refused to do further laboratory testsbecause no permission from his parents. Liver function of thosestudents were normal, anti-HBc IgM were negative, and total anti-HBc were positive in two of them.Conclusion The prevalence of HBsAg positive in junior highschool students in Bandung is low and there is no obvious riskfactor for the transmission of the disease.