Bambang Gonggo Murcitro, Bambang Gonggo
Faculty of Agriculture, University of Bengkulu, Jl. W.R. Supratman, Kandang Limun, Bengkulu 38371A, Indonesia

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UJI MICROTETRAZOLIUM (MTT) EKSTRAK METANOL DAUN Phaleria macrocarpa (Scheff.) Boerl TERHADAP SEL KANKER PAYUDARA MCF-7 Amir, Hermansyah; Murcitro, Bambang Gonggo
Alotrop Vol 1, No 1 (2017)
Publisher : FKIP University of Bengkulu

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Abstract

This study aimed to investigate research about cytotoxicity correlation level of Phaleria macrocarpa (Scheff) Boerl also known as Mahkota dewa leaves methanol extract against  MCF-7 cell in vitroto investigate the relationship between them in the goal to investigate alternative low cost herbal medicine agents to fight breast cancer. Cytotoxicity properties of samples against MCF-7 breast cancer cell lines was performed by using the Microtetrazolium (MTT) assay against MCF-7 cell line. The correlation between concentration of crude and cytotoxic activity was interpreted by statistical analyses. The study showed that P. macrocarpa leaves extracts showed cytoxicity activity against breast cancer MCF-7 cell lines which IC50 concentration showed at 15 µg/mL  Correlation between concentration of extract and cytotoxicity property (absorbance value) were founded in weak relationship (R = 0.372, R2 = 0.138).  It could be effect of many different compounds in the P. macrocarpa  leaves methanol extracts may cause the pharmacological interactions, so lower or higher concentration will be antagonistic effect on absorbance or cell viability. Further study on its mechanism pathway on revealing against breast cancer could be explored. Furthermore, the natural product derived from P. macrocarpa leaves methanol extracts have potential use as alternative drugs against breast cancer.
THE POTENTIAL USE OF Phaleria macrocarpa LEAVES EXTRACT AS AN ALTERNATIVE DRUG FOR BREAST CANCER AMONG WOMEN LIVING IN POVERTY Amir, Hermansyah; Murcitro, Bambang Gonggo; Ahmad, Ahmad Shamsudin; Kassim, Murni Nur Islamiah
ASIAN JOURNAL FOR POVERTY STUDIES (AJPS) Vol 3, No 2 (2017)
Publisher : Regional Network on Poverty Eradication

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Abstract

Cancer is recognized as global threat to human development and it was estimated that in 2030 there will be 22.2 million new cases of cancer and 12.7 million cancer-related deaths worldwide. Herbal medicine plant till this day all over in the word is still the main source and one of the most important fields of traditional medicine agents to fight breast cancer. The usage of plants is still important because has its own beaviour advantages such as low toxicity, easy to get, cheap and has less side effect if it is used in a right. One of this plant it has been used as a traditional medicine is a Phaleria macrocarpa (Scheff) Boerl) also known as Mahkota Dewa from Papua island. It has been used traditionally for treatment of cancers in Indonesia and also to cure many diseases. The therapeutic effect of Phaleria macrocarpa (Scheff) Boerl, is related to the its bioactive compounds contents. There are many reported compounds from Phaleria macrocarpa (Scheff) Boerl, which are found, reported and published such as Icariside, phalerin, mangiferin, gallic acid, 29-Norcucurbitacin, gentiobioside and glucoside. All compounds reported above have already published as anticancer agents,where anticancer activity were detected and showed against Hela cells, leukemia cells, cervical cancer, breast cancer, and L1210 cells. Research on Phaleria macrocarpa (Scheff.) Boerl fruit and leaves merit have been done and published, however, there are very limited research on linked correlation between the concentration of compounds and its the cytotoxicity  level. Because of that, research about correlation level of Phaleria macrocarpa (Scheff) Boerl leaves extract still need to investigate to find the relationship between them in the goal to investigate alternative low cost herbal medicine agents to fight breast cancer especially useful for low income people, thus, information about Phaleria macrocarpa (Scheff.) Boerl.Leaves became more complete. Cytotoxicity properties of samples against breast cancer cell lines was performed by using the MTT assay against MCF-7 cell line. The correlation between concentration of crude and cytotoxic activity was interpreted by statistical analyses. The study showed that Phaleria macrocarpa (Scheff) Boerl.) leaves extracts showed cytoxicity activity against breast cancer MCF7 cell lines. Correlation between concentration of extract and cytotoxicity property (absorbance value) were founded in weak relationship (R = -0.37181). It could be effect of many different compounds in the Phaleria macrocarpa (Scheff) Boerl.) leaves methanol extracts may cause the pharmacological interactions, so lower or higher concentration will be antagonistic effect on absorbance or cell viability.Further study on its mechanism pathway on revealing against breast cancer could be explored. Furthermore, the natural product derived from Phaleria macrocarpa (Scheff) Boerl.) leaves extracts have potential use in cheap alternative agents against breast cancer
Uji Coba Empat Varietas Kedelai di Kawasan Pesisir Berbasis Biokompos Bertham, Yudhi Harini; Aini, Nur; Murcitro, Bambang Gonggo; Nusantara, Abimanyu Dipo
Biogenesis: Jurnal Ilmiah Biologi Vol 6, No 1 (2018)
Publisher : Jurusan Biologi UIN Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (463.221 KB) | DOI: 10.24252/bio.v6i1.4144

Abstract

This study aims to obtain soybean varieties that are able to grow well and produce high in biocomposite coastal areas. This study was compiled using Randomized Block Design (RAKL) with single factor consisting of four varieties of soybeans namely Wilis, Grobogan, Detam I and Detam II. The results showed that the varieties of Wilis produce the highest plant height 63,13 cm, the highest percentage of pods per plant is 91,12%, the highest number of seeds per plant is 249,56 pieces, the heaviest seed weight per plant is 30,92 gram, while the Grobogan which produce the heaviest dry weight is 7,92 g, the highest K absorption is 0,22 g and the highest 100 seed weight is 18,00 g. Thus, the varieties of Wilis and Grobogan have higher adaptation rates than the Detam 1 and Detam II varieties, which has the potential to be developed in coastal areas.
PENGEMBANGAN MODUL BERWAWASAN LINGKUNGAN DALAM RANGKA MENINGKATKAN PENGETAHUAN DAN MORAL LINGKUNGAN SISWA SD DI DAERAH INDUSTRI, KOTA, PANTAI DAN DESA Murcitro, Bambang Gonggo
Perspektif Ilmu Pendidikan Vol 13 No VII (2006): Perspektif Ilmu Pendidikan
Publisher : Fakultas Ilmu Pendidikan Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (133.791 KB) | DOI: 10.21009/PIP.131.2

Abstract

This research is directed to create enviromental friendly moduls that can be used for improving knowledge and moral of elememtary student enviromentals in industrial areas, cities, beach and farming areas. The research was condusted on 150 elementary students of the sixth grade selected with cluster random sampling. The research resulth showed that: 1) The moduls could be em ployed to increase the knowledge of elementary students about enviroments in industrial areas, beach, cities and farming areas. Through the testing of the hypothesis on the student knowledge data using Anacova test, it was obtained the calculated F as big as 1.98 that less than the table F value 2.68. 2) Enviromental friendly moduls can be utilized to increase the moral of elementary student concerning environments industrial areas, beach, cities and forming areas. Though the hypothesis testing uses Anacova to the data of student moral about enviromental, it was obtaind that a the calculated F value as great as 0.31 that means lesses than the table F value of 2. 68.
PEMANFAATAN LINGKUNGAN SEKOLAH MELALUI PENDEKATAN OUTDOOR DALAM PEMBELAJARAN SAINS DI SD Murcitro, Bambang Gonggo
Perspektif Ilmu Pendidikan Vol 14 No VII (2006): Perspektif Ilmu Pendidikan
Publisher : Fakultas Ilmu Pendidikan Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (186.767 KB) | DOI: 10.21009/PIP.142.5

Abstract

The objectives of primary education is to give students basic competence to develop their life as an individual, as part of a community and as citizen. On the other hand, the objective of a nature science in primary education is to give students competencies to develop their knowledge, skill, and attitude that is useful in their daily life. Nature science in primary education refers to knowledge rather science. It means that what is teach in primary education are practice things, useful to the living and then in any circumstances and any life aspects. The mission and objectives in teaching nature science in primary education is related to the environment problems in school environment as well as community environment problems in school environment around the students. The environment around the kids should have been used by the teacher to teach natural science because the environment itself the objective, source, and learning facilities. The manufacture of teaching natural science in primary education can be obtained by doing a meaningful learning process.