Hermansyah Amir, Hermansyah
Faculty of Education, University of Bengkulu Bengkulu, Jl. W.R. Supratman, Kandang Limun, Bengkulu 38371A, Indonesia

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UJI MICROTETRAZOLIUM (MTT) EKSTRAK METANOL DAUN Phaleria macrocarpa (Scheff.) Boerl TERHADAP SEL KANKER PAYUDARA MCF-7 Amir, Hermansyah; Murcitro, Bambang Gonggo
Alotrop Vol 1, No 1 (2017)
Publisher : FKIP University of Bengkulu

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This study aimed to investigate research about cytotoxicity correlation level of Phaleria macrocarpa (Scheff) Boerl also known as Mahkota dewa leaves methanol extract against  MCF-7 cell in vitroto investigate the relationship between them in the goal to investigate alternative low cost herbal medicine agents to fight breast cancer. Cytotoxicity properties of samples against MCF-7 breast cancer cell lines was performed by using the Microtetrazolium (MTT) assay against MCF-7 cell line. The correlation between concentration of crude and cytotoxic activity was interpreted by statistical analyses. The study showed that P. macrocarpa leaves extracts showed cytoxicity activity against breast cancer MCF-7 cell lines which IC50 concentration showed at 15 µg/mL  Correlation between concentration of extract and cytotoxicity property (absorbance value) were founded in weak relationship (R = 0.372, R2 = 0.138).  It could be effect of many different compounds in the P. macrocarpa  leaves methanol extracts may cause the pharmacological interactions, so lower or higher concentration will be antagonistic effect on absorbance or cell viability. Further study on its mechanism pathway on revealing against breast cancer could be explored. Furthermore, the natural product derived from P. macrocarpa leaves methanol extracts have potential use as alternative drugs against breast cancer.
PERBANDINGAN HASIL BELAJAR SISWA MENGGUNAKAN MEDIA CALL CARD DAN TRUTH AND DARE Meilan, Wise; Rohiat, Salastri; Amir, Hermansyah
Alotrop Vol 1, No 1 (2017)
Publisher : FKIP University of Bengkulu

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This study aimed to compare the learning outcomes of students with using cooperative learning type Team Games Tournament (TGT) with media Call Card and Truth and Dare in SMA Negeri 05 Bengkulu Tengah. This research is quasy experimental with population all grade students in SMA Negeri 05 Bengkulu Tengah and the sample is X3 class as experiment class 1which implement instructional media truth and dare and X1 class  as experiment class 2 which implement instructional media Call Card. Students learning outcomes in this research extend from the difference of pretest and posttest value. In the experimental class 1 average value of students learning outcomes 69,46 while the experimental class 2 at 58,21. Through a series of statistical test done hypothesis testing using t test (0,01) was obtained t =3,13 and t table =2,39. The results of data analysis showed that shere were significant differences in student learning result between the aplication of instructional media Truth and Dare with media Call Card in hydrocarbon compound material in X grade SMA Negeri 05 Bengkulu Tengah. This can be showed t test that has been done on student learning outcomes for cognitife aspect got the result that value t table < t. The obtained t = 3,133 mean while t table = 2,397. 
THE POTENTIAL USE OF Phaleria macrocarpa LEAVES EXTRACT AS AN ALTERNATIVE DRUG FOR BREAST CANCER AMONG WOMEN LIVING IN POVERTY Amir, Hermansyah; Murcitro, Bambang Gonggo; Ahmad, Ahmad Shamsudin; Kassim, Murni Nur Islamiah
ASIAN JOURNAL FOR POVERTY STUDIES (AJPS) Vol 3, No 2 (2017)
Publisher : Regional Network on Poverty Eradication

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Cancer is recognized as global threat to human development and it was estimated that in 2030 there will be 22.2 million new cases of cancer and 12.7 million cancer-related deaths worldwide. Herbal medicine plant till this day all over in the word is still the main source and one of the most important fields of traditional medicine agents to fight breast cancer. The usage of plants is still important because has its own beaviour advantages such as low toxicity, easy to get, cheap and has less side effect if it is used in a right. One of this plant it has been used as a traditional medicine is a Phaleria macrocarpa (Scheff) Boerl) also known as Mahkota Dewa from Papua island. It has been used traditionally for treatment of cancers in Indonesia and also to cure many diseases. The therapeutic effect of Phaleria macrocarpa (Scheff) Boerl, is related to the its bioactive compounds contents. There are many reported compounds from Phaleria macrocarpa (Scheff) Boerl, which are found, reported and published such as Icariside, phalerin, mangiferin, gallic acid, 29-Norcucurbitacin, gentiobioside and glucoside. All compounds reported above have already published as anticancer agents,where anticancer activity were detected and showed against Hela cells, leukemia cells, cervical cancer, breast cancer, and L1210 cells. Research on Phaleria macrocarpa (Scheff.) Boerl fruit and leaves merit have been done and published, however, there are very limited research on linked correlation between the concentration of compounds and its the cytotoxicity  level. Because of that, research about correlation level of Phaleria macrocarpa (Scheff) Boerl leaves extract still need to investigate to find the relationship between them in the goal to investigate alternative low cost herbal medicine agents to fight breast cancer especially useful for low income people, thus, information about Phaleria macrocarpa (Scheff.) Boerl.Leaves became more complete. Cytotoxicity properties of samples against breast cancer cell lines was performed by using the MTT assay against MCF-7 cell line. The correlation between concentration of crude and cytotoxic activity was interpreted by statistical analyses. The study showed that Phaleria macrocarpa (Scheff) Boerl.) leaves extracts showed cytoxicity activity against breast cancer MCF7 cell lines. Correlation between concentration of extract and cytotoxicity property (absorbance value) were founded in weak relationship (R = -0.37181). It could be effect of many different compounds in the Phaleria macrocarpa (Scheff) Boerl.) leaves methanol extracts may cause the pharmacological interactions, so lower or higher concentration will be antagonistic effect on absorbance or cell viability.Further study on its mechanism pathway on revealing against breast cancer could be explored. Furthermore, the natural product derived from Phaleria macrocarpa (Scheff) Boerl.) leaves extracts have potential use in cheap alternative agents against breast cancer
ANALISIS KEMAMPUAN BERPIKIR KRITIS MATA PELAJARAN KIMIA PADA SISWAKELAS XI IPA SMAN 1 KEPAHIANG Yunita, Selly; Rohiat, Salastri; Amir, Hermansyah
Alotrop Vol 2, No 1 (2018)
Publisher : FKIP University of Bengkulu

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[ANALYSIS OF THE CRITICAL THINKING ABILITY FROM CHEMICAL SUBJECTS IN STUDENTS OF CLASS XI IPA SMAN 1 KEPAHIANG] This research aims to know the critical thinking ability of students. Type of this research is descriptive research using quantitative methods. This research was carried out in SMA Negeri 1 Kepahiang on September 2 to 8 may in 2017. The population in this research is the entire class XI IPA are registered on the even-numbered school year 2016/2017 semester. As the samples are taken at class XI IPA 6 of 32 participants.  Data collection is done with the test in the form of reserved descriptions as much as 10 round the whole includes indicators of critical thinking from the taxonomy of Bloom that is level (C2) understand (C3), apply (C4), analyzing and evaluating (C5). Test results obtained from the analysis of results the percentage of students with the ability to answer a question of thinking very critically at 15,6%, quite critical at 53,2 %, and less critical at 31,2 %, with an average value of 61.81. From the average of the values obtained showed that students who have average value included in the category of being. Based on the analysis of the data collected can be inferred levels of critical thinking ability of the students in class XI IPA 6 SMA Negeri 1 Kepahiang at school 2016/2017 academic year can be grouped in a category group are of 53,2 %, middle , 15,6 %  at high group and 31,2 % at low groups. From the results, it can be concluded that overall students in grades at  XI IPA 6 SMA Negeri 1 Kepahiang even 2016/2017 academic year with the ability to enough think critically.
PENENTUAN PARAMETER ADSORPSI SILIKA SINTETIK DARI CANGKANG KELAPA SAWIT TERHADAP KANDUNGAN AMMONIUM PADA LIMBAH CAIR TAHU Karimullah, Rizki; Elvia, Rina; Amir, Hermansyah
Alotrop Vol 2, No 1 (2018)
Publisher : FKIP University of Bengkulu

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[DETERMINATION OF SYNTHETIC SILICA ADSORPTION PARAMETERS OF OIL PALM SHELLS AGAINST THE CONTENT OF AMMONIUM ON LIQUID TOFU WASTE] This research aims to determine adsorption capacity of synthetic silica synthesized from Palm Oil (Elaeis guineensis Jacq) shells ashes against the content of Ammonium on tofu liquid waste . The shell sample soaked in a solution of HCl 10% for 2 hours, charred at a temperature of  300 °C for 3 hours ago ashed at 600 °C for 2 hours. Then ash soaked with HCl 1.2 M for 24 hours.  Taken 120 g of ash shells and then mixed right while heated with 160 mL 4 M NaOH. The residue obtained is heated at a temperature of 5000 °C  for 30 minutes, cooled to room temperature and retrieved the Na2SiO3 particle.The particle then  dissolved into 200 ml aquademin and settled at 12 hours, filtered and filtratnya ditetesi with HCL 1 M while stirring, until the white gel is formed and settled in the next 24 hours, filtered, and dried at a temperature of 120 °C for 2 hours, an silica powder obtained as result.  Ammonium Adsorption is done with mass variation 0125, 0.25, 0.5, 0.75, and 1 g silica as well as variations of the contact time of 15, 30, 60, 90, and 120 minutes. The results showed Ammonium adsorption at tofu liquid waste by silica synthesis from the Palm Oil shell ashes occurs with a maximum mass of 0.25 g and optimum contact time of 30 minutes with a capacity of adsorption of 2.581 mg/L and 3,154 mg/L as well as with adsorption efficiency at  61.9% and 76.8%.
POTENSI EKSTRAK METABOLIT SEKUNDER Eugenia uniflora L. SEBAGAI BAHAN PENGAWET TAHU Tria, Genesis; Nurhamidah, Nurhamidah; Amir, Hermansyah
Alotrop Vol 2, No 1 (2018)
Publisher : FKIP University of Bengkulu

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[POTENTIAL OF Eugenia uniflora L SECONDARY METABOLITES EXTRACT AS A TOFU PRESERVATIVE]. The purpose of this research is to know the secondary metabolite compounds from the Eugenia uniflora L (Dewandaru) fruit extracts , as well as to measure the potential of water extract from the fruit of E. uniflora L for the use in the tofu preserve as well as measure the impact of the addition of water extract of the fruit of E. uniflora L against moisture, pH, protein on tofu. The process of preserving test against tofu on the research done by soaking time at 2, 3 and 4 hour with each variation of the concentration of extract at  10, 15 and 20% as well as the observation time at 24 and 48 hours for each treatment.The result of the test water extract of the fruit of the phytochemical profile E. uniflora L showed the content of alkaloids, flavonoids, phenolic , saponins and steroid compounds. Test results from the granting of water extract from the fruit of E.uniflora L in the preserve of tofu with the variation of concentration and soaking time is proven to affect the value of water content, pH, and protein on tofu that was tested.The results of the research done indicate that the granting of a water extract of the fruit of E.uniflora L proven useful to be used as a natural preservative for tofu at 24 hours with a 20% concentration and a soaking time at 2 and 3 hours. From the results, it can be concluded that water extracts from the fruit of E.uniflora L. potential to be used as a natural preservative for tofu.
HUBUNGAN MINAT BELAJAR SISWA DENGAN PRESTASI BELAJAR SISWA PADA MATA PELAJARAN KIMIA DI SMA NEGERI 1 TEBAT KARAI DAN SMA NEGERI 1 KABUPATEN KEPAHIANG Rozikin, Slamet; Amir, Hermansyah; Rohiat, Salastri
Alotrop Vol 2, No 1 (2018)
Publisher : FKIP University of Bengkulu

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[RELATIONSHIP OF STUDENTS LEARNING ACHIEVEMENTS WITH STUDENTS LEARNING INTEREST IN THE    CHEMISTRY SUBJECTS AT SMA NEGERI 1 TEBAT KARAI AND SMA NEGERI 1 KEPAHIANG] This study aims to measure the significance of relationships of interest in learning chemistry with the result of chemical learning students in class X IPA residing in SMA Negeri 1 Tebat Karai and a in SMA Negeri 1 Kepahiang at 2016/2017 academic year.. The research is the correlation research. The population in this research is the whole  class  of X IPA grade in  SMAN 1 Tebat Karai and SMAN 1 Kepahiang at 2016/2017 academic year with total population 218 students who at was a total sample of research. Data collection techniques in the study used the instruments form of the interest in learning chemistry. Data analysis tested using correlation analysis, test validity, reliability, linear regression and hypothesis testing. Based on the analysis of the data obtained to the conclusion that there was a significant positive relationship between interest in study with the results of the study chemistry well in SMA Negeri 1 Tebat Karai and SMA Negeri 1 Kepahiang, indicated from the value of F test  is greater than F table (30.225 > 3.885) with contributions amounting to 76.4%  with the most significant influence indicator is an understanding of the concept of the learning materials with the value of the average correlation of 0,377, 14. From the results of research conducted obtained the conclusion that that interest in learning affects student learning results in class X SMA Negeri 1 Tebat Karai and SMA Negeri 1 Kepahiang. 
PREPARASI DAN KARAKTERISASI MIKROKRISTALIN SELULOSA (MCC) BERBAHAN BAKU TANDAN KOSONG KELAPA SAWIT (TKKS) Effendi, Fepri; Elvia, Rina; Amir, Hermansyah
Alotrop Vol 2, No 1 (2018)
Publisher : FKIP University of Bengkulu

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[PREPARATION AND CHARACTERIZATION OF MICROCRYSTALLINE CELLULOSE (MCC) MADE FROM EMPTY PALM OIL BUNCHES (TKKS)] Empty Palm bunches (TKKS) is solid waste from industrial processing of oil palm (Elaeis guineensis Jacq) that have a high cellulose content.  This research aims to synthesize Microcrystalline Cellulose (MCC) from TKKS and determine the characteristics of the MCC produced. The manufacturing process begins with the MCC delignifikasi multistage pulping TKKS using mixed of 3.5% HNO3 and NaNO2 in temperatures of 90 ?C for 2 hours, followed by heating of a mixture of 2% NaOH and Na2SO3 2 % at temperature 50?C for 2 hours. The second stage of the lignification process is done using NaOH 17.5 %, followed by hydrolysis towards ?-Cellulose lignification results with heating in the aqueous solution of HCl at concentrations of 3, 3.5 and 4 M for 30, 45 and 60 minutes. From the results obtained from the hydrolysis of the optimum yield of 80.73 %, i.e., MCC that use concentration of HCl 3 M for 30 minutes.  MCC produced then analyzed using FTIR, XRD, and PSA. FTIR absorption for MCC results showed an of waves number on a 3375.43 cm-1 and 2899,01cm-1, indicating the presence of hydroxyl OH and CH.The results of the analysis with the PSA suggests that MCC has generated a measure of particle diameter 0.5281 µm. Using XRD analysis results that MCC has a degree of crystallinity of 86,79 %. And the results of testing the content of carbohydrates in MCC produced shows levels of carbohydrates of 88.36 %.
KORELASI PENGARUH FAKTOR EFIKASI DIRI DAN MANAJEMEN DIRI TERHADAP MOTIVASI BERPRESTASI PADA MAHASISWA PENDIDIKAN KIMIA UNVERSITAS BENGKULU Amir, Hermansyah
Manajer Pendididikan Vol 10, No 4 (2016)
Publisher : Manajer Pendididikan

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The purposes of this study were to analyze using correlational techniques about relationship between self-efficacy and self-management factor on achievement motivation ofChemistry students at Teacher Training and Education Faculty from University of Bengkulu. Respondent population is 140 , and the samples are 104 students, where primary data wasanalyzed with SPPS 16. The results of the study generally indicated that there was a significant and linear effect , partially or together from effect self-efficacy and self-management onachievement motivation of students, which the aspects of self-management was had a greater influence than the aspects of self-efficacy on achievement motivation possessed by the student where all the three aspects are linked and related to each otherKeywords: self-efficacy, self-management, achievement motivation
POTENSI SITOTOKSIK DAN ANTIBAKTERI EKSTRAK DAUN Laportea interrupta (L.) Chew (JELATANG AYAM) TERHADAP Staphylococcus aureus Safitri, Okti Mindi; Nurhamidah, Nurhamidah; Amir, Hermansyah
Alotrop Vol 2, No 2 (2018)
Publisher : FKIP University of Bengkulu

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This research aims to determine the profile of phytochemicals, determine the level of cytotoxic extract toward the larva of Artemia salina Leach by using Brine Shrimp Lethality Test (BSLT) method, and to measure how much the activity of  antibacteria leaf ekstract of Laportea Interrupta (L.) Chew  (Jelatang Ayam )  toward the Staphylococcus aureus bacteria. The leaf of L. interrupta  (L.) Chew are dried and grinded well. The half of grinded sample are tested by phytochemical  profile and another one are ekstracted by using etanol liquid for three days then they are evaporated. The result of fitokimia leaf L. interrupta  (L.) Chew test contains secondary metabolite alkaloid,  tanin, terpenoid,  and saponin. The result of cytotoxic extract of leaf L. interrupta  (L.) Chew toward the A. salina Leach is obtained LC50 for 93,33 ppm, so, the L. interrupta  (L.) Chew is toxic because it is in the range of 31 ppm to 1000 ppm and it can be potentially as a anticancer agents. The eksract of Jelatang Ayam leaf can obstruct the growth of S. aureus, on 5 x 104 clear zone concentration that formed 9 mm being medium categorized. The more concentration of the Jelatang leaf ekstract then more its obstruction energy.