soedarto soedarto, soedarto
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IgG and IgM titres Problems in Determining Diagnosis of Toxoplasmosis soedarto, soedarto
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 6, No 2 (2017): EDISI SEPTEMBER 2017
Publisher : Universitas Wijaya Kusuma Surabaya

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Abstract

To determine acute Toxoplasma gondii infection in pregnant women, is of interest worldwide due to the risk of congenital toxoplasmosis. Ability to diagnose recently acquired infection in the pregnant woman and congenital infection in the fetus and newborn was improved. Interpreting on maternal serological screening tests by new methods  should not rely on a single sample test but need confirmatory testing through a nationally recognized reference laboratory if results of serological tests are positive.
LYMPHOCYTE-T TYPE TH1 AND TH2 ACTIVITY DIFFERENCE OF LUNG TISSUE ON Heligmosomoides polygyrus NEMATODE AND Mycobacterium tuberculosis SEQUENTIAL CO-INFECTION Wulandari, Laksmi; Amin, Muhammad; Soedarto, Soedarto; Soegiarto, Gatot
Folia Medica Indonesiana Vol 53, No 2 (2017): JUNE 2017
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (371.852 KB) | DOI: 10.20473/fmi.v53i2.6356

Abstract

Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis that are often associated with uneffectiveness of the BCG vaccine and the high worm infection. The objective of this study was to determine the differences in the activity of Limfosit T type Th1 (IFN-g) and Th2 (IL-4) in lung tissue on Heligmosomoides polygyrus nematode and Mycobacterium tuberculosis sequential co-infection. This research using 49 mice were divide into 7 groups treated with infection by Mycobacterium tuberculose inhaled and Heligmosomoides polygyrus orally within 8 and 16 weeks. The levels of IFN-g in peripheral blood serum (89.929 + 3.533 pg/mL) resembles the pattern of the percentage of lymphocytes T CD4+ Th1 in lung tissue (3.246 + 0.519%) and peripheral blood (4.950 + 0.237%), while the levels IL-4 in the peripheral blood serum (20.782 + 4.043%) resembles the pattern of the percentage of lymphocytes T CD4+ Th2 in intestinal tissue (1.048 + 0.359%) and peripheral blood (1.196 + 0.557%). In conclusion, there is difference in the activity of lymphocytes T type Th1 and Th2 but it does not affect the immune response to Mycobacterium tuberculosis infection.