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Hubungan perilaku hidup bersih dan sehat dengan kejadian infestasi Soil–transmitted Helminths pada pekerja perkebunan kopi Sumber Wadung Kabupaten Jember

Jurnal Kedokteran Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol 6, No 1 (2019): Januari 2019
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Infestasi Soil - Transmitted Helminths (STH) merupakan masalah kesehatan yang masih sering ditemukan di negara beriklim tropis, salah satunya di Indonesia. Hal ini dikarenakan perkembangan STH membutuhkan kondisi lingkungan yang hangat dan lembab, serta  memerlukan media tanah untuk menjadi fase infektif yang disebut soil - transmitted helminth.Kondisi ini dapat ditemukan di lingkungan perkebunan yang sangat menguntungkan bagi perkembangan STH. Hal ini menyebabkan para pekerja perkebunan sangat beresiko terinfestasi oleh STH. Tujuan penelitian ini adalah mengetahui adanya hubungan perilaku hidup bersih dan sehat (PHBS) dengan kejadian infestasi STH pada pekerja perkebunan kopi. Jenis penelitian ini adalah penelitian analisis deskriptif dengan desain cross-sectional yang dilaksanakan pada bulan Desember 2018 hingga Januari 2019. Perkebunan yang dipilih adalah Perkebunan Kopi Sumber Wadung di Kabupaten Jember dengan jumlah sampel sebanyak 100 orang responden dan diberikan kuisioer PHBS. Pemeriksaan infestasi STH dilakukan dengan dua metode yaitu flotasi dan sedimentasi. Dari 100 responden, 28 pekerja (28%) terinfestasi oleh STH. Kemudian dilakukan uji analisis chi-square antara PHBS dengan kejadian infestasi STH dan didapatkan adanya hubungan antara PHBS dengan kejadian infestasi STH pada pekerja (<0,05).

Pengaruh Pemberian Ekstrak Etanol Brokoli (Brassica oleracea) terhadap Kadar SGOT dan SGPT Tikus Wistar yang Diinduksi DMBA (The Effect of Ethanolic Extract of Broccoli (Brassica oleracea) on SGOT and SGPT of Wistar Rats Induced by DMBA)

Pustaka Kesehatan Vol 4 No 2 (2016)
Publisher : UPT Penerbitan Universitas Jember

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Abstract

DMBA is a product of incomplete burning which can cause free radicals in human. The metabolism of DMBA by Cytochrome P450 in liver causes hepatocyte DNA damage and decrease endogenous antioxidant. Broccoli contains flavonoid which can act as an antioxidant by inhibiting formation of free radicals through hydrogen atom donation to free radicals. This research aimed to analyze the effect of ethanolic extract of broccoli on SGOT and SGPT of wistar rats induced by DMBA. This research used 24 rats divided into six groups: control group, negative control group, and four treatment groups with broccoli ethanolic extract of 250 mg/kgBW, 500 mg/kgBW, 1000 mg/kgBW, and 2000 mg/kgBW for 7 days. The SGOT and SGPT levels of control group were 70,36 U/L and 33,97 U/L; negative control group 107,16 U/L and 56,21 U/L; the first treatment 101,50 U/L and 49,33 U/L; the second treatment 85,32 U/L and 43,67 U/L; the third treatment 84,11 U/L and 40,84 U/L; and the fourth treatment 81,28 U/L and 35,18 U/L. The result of One Way Annova test for SGOT was p=0,012 while SGPT was p=0,003. In this study, ethanolic extract of broccoli could protect hepatocyte by decreasing SGOT and SGPT levels.   Keywords: ethanolic extract of broccoli, SGOT and SGPT levels, DMBA

Overview of Depression in The Elderly of UPT Pelayanan Sosial

Journal of Agromedicine and Medical Sciences Vol 2, No 2 (2016)
Publisher : Medical Faculty of Jember University (Fakultas Kedokteran Universitas Jember)

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Abstract

Depression is a prolonged sadness and a feeling or abnormal. Can be used to demonstrate a variety of phenomena, such as signs, symptoms, syndrome, emotional, reaction. Depression is more common in older people than depression in the general population with a prevalence rate of 25-50%. Elderly according to article 1, paragraph (2), (3), (4) of Law No. 13 of 1998 on the health of the elderly is said that a person who has reached the age of 60 years. The purpose of this study to determine the incidence and the general picture of depression that occurs at the level of the elderly who live in UPT Pelayanan Sosial Lanjut Usia Kabupaten Jember. This study is observational analytic cross sectional design. The variables observed in this study is the age and level of depression. Respondent has been investigated by using the GDS (Geriatric Depression Scale). Population in this study was all elderly that live in UPT Pelayanan Sosial Lanjut Usia Jember as much as 43 respondents. Spearman Rho analysis showed significance level 2.57 which shows 2.57> 0.05 p. This means that there is no significant relationship between age of elderly with depression levels among respondents in UPT Pelayanan Sosial Lanjut Usia Kabupaten Jember. Key words: Depression, Elderly.

The Effect of Hemodialysis on Kinetic Segment of Left Ventricular in Stage V Chronic Kidney Diseases Patients

NurseLine Journal Vol 3 No 1 (2018): Mei 2018
Publisher : Faculty of Nursing, University of Jember

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Abstract

Chronic kidney disease (CKD) stage V attacks other organs such as heart that can cause cardiovascular disease (CVD). One of them is CVD caused by CKD stage V that is the kinetic segment of left ventricle. Cardiovascular disease occurs due to excess fluid and buildup of uremic toxin. Chronic kidney disease stage V can not be cured so it requires therapy that is hemodialysis (HD). Hemodialysis can reduce excess fluid, uremic toxin, and maintain electrolyte balance in stage V stage. Improved fluid and decreased uremic toxin can reduce the burden of the heart and strain so that blood supply to certain myocardial areas increases and the left ventricular kinetic segment increases. The purpose of this study is to determine the effect of HD on left ventricular kinetic changes in CKD stage V patients in dr. Soebandi hospital in Jember. The research design used was quasi-experimental one group pretest-postest design. The sample was 30 patients. Respondents were determined by nonprobability sampling technique with purposive sampling method. The data used are primary data and secondary data. Data analysis using Wilcoxon test. Based on the results of the study, the distribution of the sample based on the age of the most in the range of 45-54 years, based on the sex obtained more women, based on the duration of hemodialysis obtained the period of most hemodialysis> 24 months and based on blood pressure before and after hemodialysis obtained patients with hypertension. Hypothesis test using Wilcoxon test got p-value (0.000). From the results of the analysis can be concluded that there is influence of hemodialysis on kinetic segment of left ventricle in patient of CKD stage V in dr. Soebandi hospital in Jember.   

Type 3 Resistant Starch Effect of Cassava (Manihot esculenta Crantz) on Fasting Blood Glucose in Diabetes Mellitus Wistar Rat Models

Journal of Agromedicine and Medical Sciences Vol 4 No 3 (2018)
Publisher : Medical Faculty of Jember University

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Abstract

Type 2 Diabetes Mellitus (T2DM) is a condition in which both insulin secretion and insulin sentivity disturbed. One of therapeutic approach of T2DM is through diet modification using resistant starch (RS) that has proven controlling both postprandial and fasting blood glucose. Cassava starch has 28,57% amylose and 51,24% amylopectin that can be increased through autoclaving-cooling process. Therefore, it can resist the digestion proess by amylose enzyme. The aim was to describe the effect of type 3 resistant starch cassava (Manihot esculenta Crantz) on fasting blood glucose (FBG) in Wistar diabetic rat models. This study was quasy experimental post-test only control group design using 16 Wistar rats divided into 4 groups, KN (normal), K- (DM), P1 (DM + cassava starch diet), and P2 (DM + type 3 RS cassava diet). High fat diet (HFD) and low dose streptozotocin (STZ) used as diabetic agents. Rats fed cassava starch or type 3 RS cassava diet for 28 days. GOD-PAP method used to measure the FBG level. The data analyzed using One Way ANOVA test with p>0,05 as significant value. The result shows no significant differences within experimental groups. Keywords: cassava, autoclaving-cooling, resistant starch, FBG

Efek Analgesik Kombinasi Kurkumin dan Parasetamol pada Mencit yang Diinduksi Asam Asetat menggunakan Isobologram (The Analgesic Effect of Combination of Curcumin and Paracetamol in Acetic acid-induced Mice using Isobolograms)

Pustaka Kesehatan Vol 5 No 2 (2017)
Publisher : UPT Penerbitan Universitas Jember

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Abstract

Paracetamol is a drug that classified as NSAID and commonly used as analgesic agent. These drugs have toxic effects that lead to liver damage. This effects caused by accumulation the metabolite compound of paracetamol, N-acetyl-p-benzoquinone (NAPQI), by cytochrome P450 enzyme. Some studies reported that curcumin have analgesic effects and inhibit action of cytochrome P450 enzyme. The purpose of this study was to determine the analgesic effect of curcumin and paracetamol combination in 27 acetic-acid induced mice. The result of this study showed that 2358,815 µg of curcumin and paracetamol combination can inhibit pain up to 50%. This result is smaller than paracetamol that need 4200 µg to achieve the same pain inhibition. One Way Annova test showed siginificant difference between paracetamol group and combination group. Isobolographic analysis results showed curcumin and paracetamol have synergistic properties in mice acetic-acid induced pain. Keywords: curcumin, paracetamol, isobolograph  

Efek Analgesik Kombinasi Kurkumin dan Parasetamol pada Mencit yang Diinduksi Asam Asetat menggunakan Isobologram (The Analgesic Effect of Combination of Curcumin and Paracetamol in Acetic acid-induced Mice using Isobolograms)

Pustaka Kesehatan Vol 5 No 2 (2017)
Publisher : UPT Penerbitan Universitas Jember

Show Abstract | Original Source | Check in Google Scholar | Full PDF (237.684 KB)

Abstract

Paracetamol is a drug that classified as NSAID and commonly used as analgesic agent. These drugs have toxic effects that lead to liver damage. This effects caused by accumulation the metabolite compound of paracetamol, N-acetyl-p-benzoquinone (NAPQI), by cytochrome P450 enzyme. Some studies reported that curcumin have analgesic effects and inhibit action of cytochrome P450 enzyme. The purpose of this study was to determine the analgesic effect of curcumin and paracetamol combination in 27 acetic-acid induced mice. The result of this study showed that 2358,815 µg of curcumin and paracetamol combination can inhibit pain up to 50%. This result is smaller than paracetamol that need 4200 µg to achieve the same pain inhibition. One Way Annova test showed siginificant difference between paracetamol group and combination group. Isobolographic analysis results showed curcumin and paracetamol have synergistic properties in mice acetic-acid induced pain. Keywords: curcumin, paracetamol, isobolograph  

Efek Hepatoprotektif Ekstrak Etanol Brokoli (Brassica oleracea L. var. italica) terhadap Kadar Malondialdehid Hepar Tikus Wistar yang Diinduksi DMBA (Hepatoprotective Effect of Ethanolic Extract of Broccoli (Brassica oleracea L. var. italica) on Liver Ma

Pustaka Kesehatan Vol 4 No 3 (2016)
Publisher : UPT Penerbitan Universitas Jember

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Abstract

DMBA (7,12-Dimethylbenz(α)antracene) is a prototype of Polycyclic Aromatic Hydrocarbons (PAHs) which is present in automobile exhaust, cigarette smoke, and wood stoves. DMBA is converted into its reactive metabolites DMBA-DE and cause liver cell membrane lipid peroxidation, which results in an increased of liver malondialdehyde (MDA) levels. Broccoli contains flavonoid that able to prevent lipid peroxidation. The current study was conducted to find out the different hepatoprotective effect of ethanolic extract of broccoli against DMBA-induced hepatotoxicity in wistar rats using liver MDA as a marker. A total of 24 male wistar rats were divided into six groups, consisting of normal control (distilled water), negative control (DMBA), and treatment (ethanolic extract of broccoli in doses of 250, 500, 1000, and 2000 mg/kgBW). Rats were treated for 7 days prior to a single dose of DMBA on the 8th day of treatment. Liver tissue samples were taken on the 12th day for measurement of liver MDA levels. Data were analyzed using One Way ANOVA followed by Post Hoc Test LSD. The present study showed significant differences on liver MDA levels between groups (p<0.001). This study concluded that there were different hepatoprotective effects of ethanolic extract of broccoli treatment on liver MDA levels in wistar rats induced by DMBA.   Keywords: ethanolic extract of broccoli, DMBA, malondialdehyde, hepatoprotective  

Aedes aegypti Mosquito Potential Larvacidal of Phyllantus niruri L. Leaves Ethanol Extracts

Journal of Agromedicine and Medical Sciences Vol 5 No 1 (2019)
Publisher : Medical Faculty of Jember University

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Abstract

Dengue hemorrhagic fever (DHF) is a disease caused by dengue virus transmitted by Aedes aegyptifemale mosquitoes with four major clinical manifestations, such as high fever, hemorrhage,hepatomegaly, and signs of circulatory failure. Indonesia was reported as the 2nd country with thelargest dengue cases among 30 endemic countries. The larvicidal powder is used as one of thedengue virus vector controllers. This study aims to determine the effect of ethanol extract of smallgooseberry leaves (Phyllantus niruri L.) to the death of Aedes aegypti mosquitoes. This study usedquasi experimental method with post test only controlled group design with 1 positive control group(Temephos), 1 group of negative control (tap water), and 5 treatment groups (0.0625%, 0.125%,0.25% , 0.5% and 1% extract) used 20 larvaes of Aedes aegypti instar III each group. The results of thetreatment group extract with a concentration of 0.5% and 1% obtained 100% dead larvae. The resultof linear regression test showed the effect of meniran leaf extract on the death of larvae Ae. aegyptiwith R2 value of 65.2%. The larvacid activity of ethanol extract leaves meniran against larvae Ae.aegypti instar III was directly proportional to concentration with LC50 of 0.174% with 95% confidenceinterval (0.155-0.195).