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LITERATURE REVIEW: THERAPEUTIC APPLICATION OF GERANIIN FROM RAMBUTAN (Nephelium lappaceum) PEEL EXTRACT AS ANTIHYPERGLYCEMIC THROUGH ITS ANTIOXCIDANT ACTIVITY IN TYPE 2 DIABETES MELLITUS

NurseLine Journal Vol 1 No 1 (2016): Mei 2016
Publisher : Faculty of Nursing, University of Jember

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Abstract

Diabetes mellitus is a disorder in the metabolism of carbohydrates, lipids and proteins, which is characterized by hyperglycemia. Its prevalence in the world is increasing, especially type 2 diabetes, causes an increased incidence of morbidity and mortality throughout the world due to complications of hyperglycemia. Hyperglycemia stimulates the release of superoxide (O2-) at the level of mitochondria which is the trigger early onset of oxidative stress in patients with diabetes mellitus type 2. Therefore one of the therapeutic modalities that can be developed in type 2 diabetes mellitus is a substance as potent antioxidant. Geraniin of rambutan peel extract is known to have the ability as a potent antioxidant and radical scavenging, so it is possible to be a prime candidate antidiabetes in the ype 2 diabetes melitus. We searched Cochrane Library data bases, Google Scholar, Medline and PubMed, from 2006 to 2016, to assess the effect of rambutan peel extract for type 2 diabetes melitus. We obtained 17 articles in accordance with the inclusion criteria. In the peel of rambutan (Nephelium lappaceum), geraniin is the main phenolic compounds that have the potential ability as an antioxidant and antihyperglycemic through inhibition of alfa-glucosidase and alfa-amylase, preventing the polyol (aldol reductase inhibition) and prevents the formation of advanced glicosilation products (AGEs). There is a very strong correlation between the ability as an antioxidant with the ability to inhibit alfa-glucosidase and alfa-amylase, so geraniin of rambutan peel extract (Nephelium lappaceum) expressed as the ideal candidate for the management of hyperglycemia in individuals with diabetes.

Effect of Soyflour (Glycine max L.) Hepatoprotector Activity on Liver MDA Level in Male Wistar Rat Induced by Diazinon

Journal of Agromedicine and Medical Sciences Vol 4 No 1 (2018)
Publisher : Medical Faculty of Jember University

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Abstract

Diazinon is metabolized in liver becomes diazoxon, an active metabolite form that can cause free radical raisingthat leads to lipid peroxidation. The result of lipid peroxidation is MDA. Soyflour has higher isoflavones than theother processed food of Glycine max L.This isoflavones donate its electron and hydrogen atom in lipidperoxidation so it can block the lipid peroxidation. The aim of this experiment is to investigate the effect of soyflour on MDA hepar level increase of male wistar rat induced by diazinon. The sample are divided into 5 groupswhich are Kn, K(-) group induced by diazinon 40mg/kgBW, K1, K2, K3 group given with soy flour 10%, 15%, and20% orally, then induced by diazinon 40 mg/kgBW. MDA liver measured on the day 34th with MDA-TBAmethode which has pink colour and measured by spectrofotometer. Average of liver MDA levels is Kn 6,35μg/mL; K(-) 9,23 μg/mL; K1 8,85 μg/mL; K2 7,88 μg/mL; K3 7,04 μg/mL. One way ANOVA and Post hoc LSDshowed significantly different (p<0,05). Pearson correlation showed strong negative correlation. Keywords: Diazinon, Diazoxon, MDA, Soyflour, Glycine max L., antioxidant

Hemodialysis Effect on Systolic Left Ventricular Function in Stage V Chronic Kidney Disease Patients

Journal of Agromedicine and Medical Sciences Vol 4 No 3 (2018)
Publisher : Medical Faculty of Jember University

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Abstract

Chronic kidney diasease (CKD) is one of world health problem with increased incidence. Kidney function impairment contribute to cardiovascular complication that has been the main cause of CKD patient death. The impairment of cardiovascular function mainly caused by decreased of systolic left ventricular function. Stage V CKD patients need renal replacement therapy such as hemodialysis. Hemodialysis known to has positive effect on cadiovascular function by decreasing volume overload and uremic toxin. Echocardiography is a non-invasive method to assess cardiovascular function i.e. systolic left ventricular function. The aim of this study is to describe the improvement of  systolic left ventricular function in stage V CKD patients after going through hemodialysis. The subject of this study are 30 patients, ≥18 years old diagnosed with Stage V CKD and undergo routine hemodialysis in RSD dr. Soebandi Jember. The data analyzed with Wilcoxon test and shown significance (p=0,000). This study concludes there is a significant improvement on systolic left ventricular function in CKD patients before and after hemodialysis in RSD dr. Soebandi Jember. Keywords: Systolic Left Ventricular Function, Hemodialysis, Chronic Kidney Disease, Echocardiography

Aktivitas Ekstrak Metanol Bawang Putih (Allium sativum) sebagai Penghambat Pembentukan Biofilm pada Pseudomonas aeruginosa (The Activity of Methanolic Extract of Garlic (Allium sativum) in Inhibiting Growth of Biofilm in Pseudomonas aeruginosa)

Pustaka Kesehatan Vol 5 No 3 (2017)
Publisher : UPT Penerbitan Universitas Jember

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Abstract

Garlic (Allium sativum) is one of the most important agricultural product that has organosulphur compound, such as alliin, allicin, and  ajoene. Those organosulphur compound used as antibiofilm agent by inhibiting adhesion and quorum sensing process in Pseudomonas aeruginosa. The purpose of study was to identify the antibiofilm effect and Minimum Biofilm Inhibitory Concentration (MBIC) of methanolic extract of garlic against the growth of P. aeruginosa biofilm. This was quasi experimental with posttest only control group design. The colony of P. aeruginosa were divided into 7 groups with 5 groups used methanolic extract of garlic as P1-P5 at a dose 0,3; 0,6; 0,9;1,2; and 1,5 mg/mL, positive control group (K+) used NAC 80 mg/mL, and negative control group (K-) used sterile water. This research using Microtitter Plate Biofilm Assay Method with 4 replication. The absorbance value was analized by using One Way Anova statistical analysis, it showed the significance value p=0,000 (p<0,05). By using linier regression, the MBIC was obtained at the dose of 0,3468 mg/mL. In conclusion, methanolic extract of garlic had ability to inhibit the growth biofilm of P. aeruginosa.   Keywords: biofilm, garlic, Minimum Biofilm Inhibitory Concentration, P. aeruginosa  

Analysis of Varicose Vein in Lower Extremities Risk Factors on Woman Laborers of Tobacco Picker at Ajung District Jember Regency

Journal of Agromedicine and Medical Sciences Vol 5 No 1 (2019)
Publisher : Medical Faculty of Jember University

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Abstract

Varicose vein (VV) in lower extremities are common diseases in the clinic but there is little concern from clinicians as they are considered mild and low mortality. The complications of VV can be ulcers or worst like Congestive Heart Failure (CHF). Several risk factors that can affect the occurrence of VV are women, age, long standing, overweight, pregnancy multiparity, and hormonal contraception. The general purpose of this research is knowing the relationship between risk factors mentioned above and the prevalence of VV on female laborers of tobacco picker at Ajung District Jember District. This research use observational analytic method with cross sectional study design to 72 people who meet the inclusion criteria by purposive sampling method. The sample were given questionnaire, informed consent, then measured by weight scales and microtoise staturemeter. The diagnosis of VV was obtained from the photos that been consulted to cardiothoracic surgeon at dr. Soebandi Hospital Jember. The result of contingency coefficient C correlation test said that only age has significant relation to VV occurrence states (p = 0,044; r = 0,231; OR = 3,053), while others are not significant (p> 0,05 and r < 0.2). The conclusion of this study is that only the age factor has a statistically significant relationship and the positive correlation with the weak correlation to the occurrence of lower extremities VV on woman laborers of the tobacco picker of Ajung District, Jember Regency. Keywords: Varicose Vein, Lower Extremities