Melawati Olevianingrum, Melawati
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C-REACTIVE PROTEIN (CRP) AS A SUPPORTING MARKER OF ANTIBIOTIC EFFECTIVENESS ON CENTRAL NERVOUS SYSTEM (CNS) INFECTIONS Olevianingrum, Melawati; Yulistiani, Yulistiani; Saharso, Darto; Zairina, Nun
Folia Medica Indonesiana Vol 51, No 3 (2015): July - September 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (87.093 KB) | DOI: 10.20473/fmi.v51i3.2821

Abstract

Infection of the central nervous system in pediatric patients have a high mortality as well as acute and chronic neurological sequelae. Signs of the disease are unclear, so cerebrospinal fluid (CSF) test is used as a gold standard for diagnosis, but the investigation has faced many obtacles. Empiric antibiotic therapy is the key factor in reducing morbidity and mortality. Microbiological culture result is obtained within 5-7 days. The effectiveness of empirical antibiotic use is questionable. Therefore, other investigations are conducted to determine the effectiveness of antibiotics by using one marker, the CRP. This study was to analyze CRP level in supporting antibiotic therapy effectiveness in pediatric patients with central nervous system (CNS) infections. A prospective cohort study was conducted to determine the relationship of CRP with other parameters, including clinical, microbiological and laboratory, in pediatric patients with central nervous system infections. Patients meeting blood samples criteria were taken before (H0), the third day (H3) and the fifth day (H5) after antibiotics administration. This study involved 10 patients with central nervous system infections (meningoencephalitis, encephalitis and encephalitis with cerebral edema). Six patients were male, with ages less than a year. Antibiotic treatment effectiveness was associated with improved condition of the patients' CRP level. It was 3.558 ±3.196 before (H0), 3.878±2.813 on the third day (H3) and 3.891±2.204 on the fifth day (H5) after antibiotic administration. Leukocyte levels were 13.680±1.660 before (H0), 17.832±7.213 on the third day (H5), and 10.546±3.671 on the fifth day (H5) after antibiotic administration. Pearson's correlation test analysis performed on CRP and WBC parameters showed H0 p=0.981, CRP and WBC H3 p=0.621, while CRP and WBC H5 obtained significance p=0.644. There was no significant correlation observed between CRP and WBC parameters before and after antibiotic administration. In conclusion, there was no correlation of CRP levels with clinical, laboratory and micobiological parameters in patients with central nervous system infections.
EFEKTIFITAS KOMBINASI MINT DAN CAIRAN DENGAN NEBULIZER PADA PENANGAN BATUK ASMA BRONCHIALE Anwari, Farida; Olevianingrum, Melawati; Fatmawati, Umi
Jurnal SainHealth Vol 3, No 1 (2019): Maret 2019
Publisher : Faculty of Health Sciences Universitas Maarif Hasyim Latif

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Abstract

Farida Anwari 1), Melawati Olevianingrum 2), Umi Fatmawati 3) (Times New Roman, 11pt, bold)STIKES RS. Anwar Medika Sidoarjo, Jl. Bypass Krian KM 33 Balongbendo, Sidoarjofaridamph@gmail.com Hp. 08123248102 ABSTRACT           Polluted air and contaminated seeds can cause various lung diseases, one of which is indicated by cough changes. Coughing into body shape, occurs as a response from the body to irritation in the throat due to mucus, dust, smoke and air outside the body. Nebulizer is an alternative tool to relieve the cough response to the presence of mucus which is an inflammatory reaction due to infection in the respiratory tract. Mint oil in the form of extracts has a variety of esters, especially menthyl acetate and monoterpenes which produce a distinctive aroma that is beneficial for breathing. The aim of the study was to examine the effect of adding mint oil as a result of distillation on the liquid with the nebulizer in cough handling.       This study was a pre-experimental study with nonrandomized design pre test and post test with control group design which was used to determine the effect of the addition of mint oil as a result of distillation on the liquid with nebulizer to reduce the coughing status of the patient which included (cough frequency, onset of inflammation, wheezing, and ease of expectoration of phlegm).      The results showed that the cough frequency status is known to have decreased from 44.4% of patients to 23.5% of patients. Similarly, the status of inflammation decreased from 41.7% to 21.7%; wheezing status which was originally 58.3% decreased to 39.1%; easy  expectoration status also shows that mint oil can reduce the level of difficulty of phlegm to go out to 13% from 36.1%.