Sharfina Sharfina, Sharfina
Fakultas Kedokteran Universitas Jember

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Efek Angiogenesis Lumbrokinase terhadap Gambaran Histopatologi Jantung Tikus Galur Wistar Hipertensi Angiogenesis Effect of Lumbrokinase on the Cardiac Histopathology of Hypertensive Wistar Rat Sharfina, Sharfina; Suryono, Suryono; Suseno, Arief
Pustaka Kesehatan Vol 3, No 1 (2015)
Publisher : Pustaka Kesehatan

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Abstract

Hypertension remains a serious health problem it is dubbed as “the silent killer”. Pathophysiology of hypertension involve alteration of vascular structure. The use of anti hypertension leads to many side effects, and many people tend to choose natural therapy. The study aimed to investigate the effect of lumbrokinase on angiogenesis as a hypertension therapy agent. In true experimental design, 22 males wistar rat were divided into control group and treatment group (Lumbrokinase 0.5 gr/KgBW/day). The results showed that the systolic blood pressure decrease after therapy with lumbrokinase from 187 mmHg to 159 mmHg whereas diastolic blood pressure consistant at 80 mmHg after induction of hypertension as well as therapy of lumbrokinase. An examination of cardiac histopathology, there was an increasing number of blood vessels in the treatment group, 10.55± 1.44 compared to 7.45± 1.21 in control group. It can be concluded that lumbrokinase had an angiogenesis effect and decrease systolic blood pressure in hypertensive rat model. Keyword : Hypertension, lumbrokinase, vascular structure, angiogenesis.
MODEL PEMBELAJARAN GENERATIF TERHADAP PENINGKATAN KETERAMPILAN PROSES SAINS SISWA KELAS X SMA NEGERI 1 KUALA Sharfina, Sharfina; Halim, Abdul; Safitri, Rini
Jurnal Pendidikan Sains Indonesia Vol 5, No 1 (2017): April 2017
Publisher : Program Studi Magister Pendidikan IPA Program Pascasarjana Unsyiah

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Abstract

Tujuan dari penelitian ini adalah untuk mengetahui pengaruh penerapan model pembelajaran generatif terhadap peningkatan KPS siswa kelas X SMA Negeri I Kuala. Penelitian ini menggunakan metode eksperimen semu dengan populasi seluruh siswa kelas X SMA Negeri I Kuala yang sampelnya dipilih secara purposive sampling. Instrumen yang digunakan untuk mengukur peningkatan KPS siswa adalah tes berbentuk pilihan ganda yang berjumlah 15 soal. Berdasarkan hasil persentase rata-rata N-gain siswa kelas eksperimen dan kontrol yaitu 36 dan 57. Hasil penelitian menunjukkan rata-rata N-Gain kelas eksperimen lebih tinggi dari kontrol. Dengan demikian dapat disimpulkan bahwa model pembelajaran generatif dapat meningkatan KPS siswa dibandingkan dengan menggunakan motede konvensional pada materi pemuaiaan di kelas X SMA Negeri I Kuala.
Efek Angiogenesis Lumbrokinase terhadap Gambaran Histopatologi Jantung Tikus Galur Wistar Hipertensi Angiogenesis Effect of Lumbrokinase on the Cardiac Histopathology of Hypertensive Wistar Rat Sharfina, Sharfina; Suryono, Suryono; Suseno, Arief
Pustaka Kesehatan Vol 3 No 1 (2015)
Publisher : UPT Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (212.085 KB)

Abstract

Hypertension remains a serious health problem it is dubbed as “the silent killer”. Pathophysiology of hypertension involve alteration of vascular structure. The use of anti hypertension leads to many side effects, and many people tend to choose natural therapy. The study aimed to investigate the effect of lumbrokinase on angiogenesis as a hypertension therapy agent. In true experimental design, 22 males wistar rat were divided into control group and treatment group (Lumbrokinase 0.5 gr/KgBW/day). The results showed that the systolic blood pressure decrease after therapy with lumbrokinase from 187 mmHg to 159 mmHg whereas diastolic blood pressure consistant at 80 mmHg after induction of hypertension as well as therapy of lumbrokinase. An examination of cardiac histopathology, there was an increasing number of blood vessels in the treatment group, 10.55± 1.44 compared to 7.45± 1.21 in control group. It can be concluded that lumbrokinase had an angiogenesis effect and decrease systolic blood pressure in hypertensive rat model. Keyword : Hypertension, lumbrokinase, vascular structure, angiogenesis.