Gunanti Gunanti, Gunanti
Department of Surgery, Faculty of Veterinary Medicine, Institut Pertanian Bogor, Bogor

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The effects of colloids or crystalloids on acute respiratory distress syndrome in swine (Sus scrofa) models with severe sepsis: analysis on extravascular lung water, IL-8, and VCAM-1 Dewi, Rismala; Supriyatno, Bambang; Madjid, Amir S.; Gunanti, Gunanti; Lubis, Munar
Medical Journal of Indonesia Vol 25, No 1 (2016): March
Publisher : Faculty of Medicine Universitas Indonesia

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Abstract

Background: Acute respiratory distress syndrome (ARDS) is a fatal complication of severe sepsis. Due to its higher molecular weight, the use of colloids in fluid resuscitation may be associated with fewer cases of ARDS compared to crystalloids. Extravascular lung water (EVLW) elevation and levels of interleukin-8 (IL-8) and vascular cell adhesion molecule-1 (VCAM-1) have been studied as indicators playing a role in the pathogenesis of ARDS. The aim of the study was to determine the effects of colloid or crystalloid on the incidence of ARDS, elevation of EVLW, and levels of IL-8 and VCAM-1, in swine models with severe sepsis.Methods: This was a randomized trial conducted at the Laboratory of Experimental Surgery, School of Veterinary Medicine, IPB, using 22 healthy swine models with a body weight of 8 to 12 kg. Subjects were randomly allocated to receive either colloid or crystalloid fluid resuscitation. After administration of endotoxin, clinical signs of ARDS, EVLW, IL-8, and VCAM-1 were monitored during sepsis, severe sepsis, and one- and three hours after fluid resuscitation. Analysis of data using the Wilcoxon test , Kolmogorov-Smirnov test, Mann-Whitney test, unpaired t test.Results: Mild ARDS was more prevalent in the colloid group, while moderate ARDS was more frequent in the crystalloid group. EVLW elevation was lower in the colloid compared to the crystalloid group. There was no significant difference in IL-8 and VCAM-1 levels between the two groups.Conclusion: The use of colloids in fluid resuscitation does not decrease the probability of ARDS events compared to crystalloids. Compared to crystalloids, colloids are associated with a lower increase in EVLWI, but not with IL-8 or VCAM-1 levels.
DIAGNOSTIC IMAGING AND ENDOSCOPY OF THE SCHNAUZER DOG WITH UPPER GASTROINTESTINAL TRACT DISORDERS Noviana, Deni; Afidatunnisa, Kholis; Syafikriatillah, Annisa Rofiqoh; Ulum, M. Fakhrul; Gunanti, Gunanti; Zaenab, Siti
Jurnal Kedokteran Hewan Vol 11, No 1 (2017): J. Ked. Hewan
Publisher : Syiah Kuala University

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The aim of this study was to describe the role of diagnostic imaging and endoscopy to define the diagnose of the upper gastrointestinal tract disorder of the Schnauzer. The information from the owner stated that the dog has been vomiting for a year, sometimes containing blood. There might also be a possibility that it had eaten a corpus alienum. This case study covered physical examination, hematology and blood chemical analysis, diagnostic imaging radiography and ultrasonography as well as endoscopy performed. Physical examination showed weight loss and anorexia. Hematology and blood chemical analysis showed an increase in hemoglobin, hematocrit, lymphocyte, ureum, creatinine, alanine aminotransferase (ALT), and alkaline phosphatase (ALP) values. Abdominal radiograph showed no abnormality in the abdominal organs. Abdominal ultrasonography showed a hiperechoic elongated mass attached on the stomach mucosal surface which forms an acoustic shadowing at the ventral.  Endoscopy showed pathological lesions that is inconsistency of stomach mucosa surface, foamy fluid in the stomach, ulcers and erosion of the stomach mucosal surface. Based on the diagnostic imaging and endoscopy performed, the animal was clearly diagnosed with chronic gastritis accompanied by stomach ulcer and erosion.
Kesembuhan Skin Flap H-Plasty dan Linear Closure untuk Penutupan Luka Area Lateral Thoraks Erwin, Erwin; Noviana, Deni; Gunanti, Gunanti; Putra, I Gusti Agung Ngurah Arphan Eka
Jurnal Sain Veteriner Vol 34, No 2 (2016): Desember
Publisher : Fakultas Kedokteran Hewan Universitas Gadjah Mada bekerjasama dengan PB PDHI

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Abstract

Skin flap is one of the techniques use for large wound closure. This study were aimed to determine the rate of cure of skin flap H-plasty and linear closure based on subjective and objective clinical observation. Six male local cats at 1-2 years old, weighing 3-4 kg, were divided into two treatment groups. All cats were made 3 x 3 cm wound in the thoracic area for skin graft. Thoracic defects were treated with skin flap techniques H-plasty (group I) and linear closure (group II). Subjective observations was performed on days 3, 6, 9 and 12 after skin flap which was covering skin discoloration, pain response, time hair growth as well a bleeding tests that performed on the 18th day after the skin flap. Objective observation was made on day 18 by administration of 0.9% NaCland observed the absorption time, while the onset of drug effect was noticed by pupillary reflex observation after 0.2 ml adrenaline injection under the skin flap. The observation on day 9 showed that skin flap linear closure wasbetter than skin flap H-plasty, which was characterized by similar skin color with surrounding skin, reduced pain response and rapid hair growth. Bleeding blood test was showed a glowing red colored and immediately came outafter incision in both groups. The absorption time of 0.9% NaCl and the effects of adrenaline were faster in thegroup skin flap linear closure. Skin flap H-plasty and linear closure techniques can be applied to repair woundsin the thoracic area of cat skin, however, the linear closure flap of skin was healing faster than skin flap H-plasty.
Ekhokardiografi Kinerja Jantung Kelinci pada Anastesi Ketamin yang Dikombinasikan dengan Xylazin, Medetomidin, atau Acepromazin (HEART RABBIT PERFORMANCE ECHOCARDIOGRAPHY IN KETAMINE ANESTHESIA COMBINED WITH XYLAZINE, MEDETOMIDINE, OR ACEPROMAZINE) Tungga Dewi, Tri Isyani; Gunanti, Gunanti; Noviana, Deni
Jurnal Veteriner Vol 19 No 2 (2018)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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Abstract

Ketamine is anesthesia that commonly used in the rabbit’s surgery as animal model often combined with transquilizer. The aim of this study is to evaluate the rabbit’s cardiac performance after administration of ketamine anesthesia combined with transquilizer. A total of 24 rabbits of New Zealand White strain were divided into four treatment groups, namely ketamine 40 mg/kg BW, combination of ketamine 10 mg/ kg BW and xylazin 3 mg/kg BW, ketamine 10 mg/kg BW and medetomidin 0.125 mg/kg BW and ketamine 10 mg/kg BW and acepromazin 1 mg/kg BW group. Evaluation were performed at 15, 30, 45 and 60 minutes after administration of anesthesia. Evaluation of cardiac performance using echocardiography on heart rate, stroke volume, ejection fraction, fractional shortening and cardiac output. The results showed that the heart rate in all treatment groups decreased along with observation time, except the ketamine group increased after 45 minutes. The stroke volume, cardiac output and fractional shortening in all treatment groups was stable, and the value was not significantly different among time observation (P> 0.05). The ejection fraction of the ketamine combined with transquilizer showed had the same pattern, decreasing at the 30 minutes observation followed by increasing at 45 and 60 minutes observation, while the ketamine group increased at 45 minutes but decreased again at minute 60. The lowest ejection fraction score was seen in the ketamine group. The research suggest that administration of ketamine with combined transquilizer medetomidin showed the most stable cardiac performance during observation. 
GAMBARAN DARAH DAN KALSIUM DOMBA LOKAL (Ovis aries) YANG DIIMPLANTASI BIFASIK KALSIUM FOSFAT 70/30 SCAFFOLD 3D BERPOROS Rahmiati, Dwi Utari; Gunanti, Gunanti; Harlina, Eva; Dahlan, Kiagus
Jurnal Veteriner Vol 19 No 4 (2018)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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Abstract

Kombinasi kalsium fosfat dengan alginat sebagai material implan tulang sudah mulai dikembangkan untuk penerapan klinis pada manusia. Penelitian ini bertujuan mempelajari biokompatibilitas bifasik kalsium fosfat dengan kombinasi alginat, dengan mengevaluasi gambaran darah dan kalsium. Penelitian ini menggunakan tiga ekor domba lokal (Ovis aries) jantan, umur 1,5 tahun, dengan berat badan rata-rata 20 kg. Bahan implan ditanam pada tibia kanan domba. Sebagai kontrol, tibia kiri domba dibuat defek namun tidak ditanam implan. Evaluasi darah dan kalsium dilakukan pada hari ke-0, 7, 30, 60 dan 90 pasca implantasi. Data yang diperoleh diolah menggunakan SPSS 16 dengan uji t paired sample. Berdasarkan nilai hematologi lengkap, tidak ada parameter darah yang signifikan. Berdasarkan nilai kalsium, diperoleh nilai signifikan pada hari ke-30 dan ke-90. Konsentrasi kalsium darah dari hari ke-0 hingga ke-90 menunjukkan penurunan