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UJI FITOKIMIA DAN AKTIVITAS ANTIOKSIDAN DARI EKSTRAK ETANOL BIJI KELENGKENG (Euphoria Iongan STEUD) DENGAN METODE PERENDAMAN RADIKAL 2,2-DIPHENIL-1-PICRYLHIDRAZYL (DPPH)

JURNAL KIMIA MULAWARMAN Vol 9 No 2 (2012)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Abstract

Kelengkeng fruit already well known for Indonesian society. Not only from the contents of the fruit, but Kelengkeng also have many other beneficial from the seed, leather, root and leaves that useful for human health. In this research, phytochemical and antioxidant activity test have been done. Antioxidant activity test was carried out with scavenging test to 2,2-diphenyl-1-picrylhidrazil (DPPH) radical. On antioxidant activity test, mix of extract and DPPH are incubated for 30 minutes at 37oC, then the absorbance measured at λ = 517 nm using spectrophotometer. The absorbance from sample, blank and negative control are converted as Antioxidant Activity Absorbance (AA%). Based on result of phytochemical etanol extract, Kelengkeng contains phenolic compounds. And based on antioxidant activity test with DPPH radical scavenging method by spectrophotometer, ethanol extract of Kelengkeng has antioxidant activity about EC50(72.23±2.55) while Vitamin C as comparison has antioxidant activity about EC50(6.07±0.36).Keywords: Kelengkeng, phytochemical, antioxidant activity and DPPH

STUDI KOMPUTASI BERBASIS DFT TERHADAP FENOMENA QUANTUM TUNNELING DALAM ISOMERISASI METILHIDROKSIKARBENA

JURNAL KIMIA MULAWARMAN Vol 9 No 2 (2012)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Abstract

Density functional theory-based methods have been applied to predict the most possible one among the isomerizations of methylhydroxycarbene considering the probability of hydrogen tunneling occurrence. B3LYP/6-31+G(d,p) and M08-SO/6-31+G(d,p) methods were applied in all computations using GAMESS-US software. There were three steps of computation in this research. First, electronic structure computations of both equilibrium and transition compounds involved in all isomerization alternatives in order to obtain the optimum structures of the compounds. Second, vibrational computations of optimum transition structures to ensure that each of the respective structures is well on its potential energy surface. Third, tunneling analysis accomplished by intrinsic reaction coordinate (IRC) computatuins for all isomerization alternatives followed by tunneling probabilitycalculation using the Wentzel-Kramers-Brillouin (WKB) formula for methylhydroxycarbene isomerizations. The result of this research showed that the DFT methods successfully produced the optimum structure of each compound. Both DFT methods also successfully mapped all the intrinsic reaction coordinates. B3LYP/6-31+G(d,p) method gave tunneling probabilities of 3.55 x 10-19 for the isomerization into acetaldehyde and 3.30 x 10-20 for that into vinyl alcohol. While M08-SO/6-31+G(d,p) method gave tunneling probabilities of 2.38 x 10-23 for the isomerization into acetaldehyde and 4.79 x 10-23 for that into vinyl alcohol.Keywords: DFT, methylhydroxycarbene, hydrogen tunneling, isomerization

THREE PRENYLATED FLAVONOIDS FROM MACARANGA PEARSONII MERR.

PROSIDING SEMINAR KIMIA PROCEEDING OF INTERNATIONAL CONFERENCE 2015
Publisher : PROSIDING SEMINAR KIMIA

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Abstract

Three prenylated flavonoids, 4’-O-methyl-8-isoprenyleriodictiol (1), 4’-O-methyl-8-isoprenylnaringenin (2) and lonchocarpol A (3) have been isolated from the leaves of Macaranga pearsonii Merr.. The structure of compounds have been elucidated based on its spectroscopic data, including UV, 1D and 2D NMR, and HREISMS spectra.

Aktivitas Antioksidan dan Antimalaria Senyawa Fenolik dari Daun Macaranga beccariana Merr.

JURNAL KIMIA MULAWARMAN Vol 15 No 2 (2018)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Abstract

Macaranga beccariana Merr. merupakan tanaman endemik Kalimantan yang diketahui belum banyak penelitian mengenai aktivitas biologi dan senyawa bioaktif dari tanaman ini. Oleh karena itu, untuk mengetahui potensi dari M. beccariana maka pengujian aktivitas antioksidan dan antimalaria serta isolasi senyawa bioaktif dari tanaman ini perlu dilakukan. Pada penelitian ini, daun M. beccariana diekstraksi dengan metanol sehingga diperoleh ekstrak metanol. Kemudian, ekstrak tersebut dipisahkan dan dimurnikan sehingga diperoleh senyawa 1 dan 2. Berdasarkan elusidasi struktur dengan spektrometer UV, 1H dan 13C NMR, senyawa 1 dan 2 diketahui sebagai kelompok senyawa fenolik dan diidentifikasi strukturnya masing-masing sebagai asam 4-hidroksibenzoat dan asam 3,4-dihidroksibenzoat. Selanjutnya dilakukan uji aktivitas antioksidan dengan menggunakan DPPH (2,2-diphenyl-1-picrylhydrazyl) dan uji aktivitas antimalarial terhadap Plasmodium falciparum strain 3D7 dengan pewarnaan Giemsa. Kontrol positif yang digunakan dalam uji aktivitas antioksidan adalah rutin, sedangkan uji aktivitas antimalaria adalah klorokuin difosfat. Hasil uji menunjukkan bahwa ekstrak metanol M. beccariana dan senyawa isolasi (1 dan 2) adalah aktif untuk kedua uji tersebut. Sehingga dapat disimpulkan bahwa daun M. beccariana memiliki potensi sebagai agen antioksidan dan antimalaria.

ANALISIS KADAR ASAM SIANIDA DALAM SOLANUM MELONGENA L DAN SOLANUM QUITOENSE L SEBELUM DAN SESUDAH PEREBUSAN

Journal of Tropical Pharmacy and Chemistry Vol 1 No 1 (2010): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117

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Abstract

ABSTRACT   Analysis cyanide acid in Solanum melongena and Solanum quitoense L before and after boiling. Cyanide acid is esthabushed by argonometricm method (Volhard) with three times repetition, for each kinds of eggplants Solanum melongena L dan Solanum quitoense L. The research showed have endireated that before boiling the content of cyanide acid Solanum melongena L (Craigi eggplant 71,712 mg/kg, kopek eggplant 46,310 mg/kg, gelatik eggplant 0 mg/kg) and Solanum quitoense L (asam eggplant 30,434 mg/kg) after boiling, the cyanide acid to slop Solanum melongena (Craigi eggplant 19,321 mg/kg, kopek eggplant 6.620 mg/kg, gelatik eggplant 0 mg/kg and Solanum quitoense L (asam eggplant 3.445 mg/kg). There is significant content have been reduced of cyanide acid in Solanum melongena L dan Solanum quitoense L   Keywords: Solanum melongena dan Solanum quitoense L, Cyanide acid   ABSTRAK   Telah dilakukan analisis asam sianida dalam Solanum melongena dan Solanum quitoense L sebelum dan sesudah perebusan menggunakan metode Volhard dengan tiga kali pengulangan. Data hasil penelitian menunjukkan kandungan asam sianida sebelum perebusan Solanum melongena (terong Craigi 71,712 mg/kg, terong kopek 46,310 mg/kg, terong gelatik  0 mg/kg)  dan Solanum quitoense L (terong asam 30,434 mg/kg) sedangkan setelah dilakukan perebusan (terong Craigi 19,321 mg/kg,  terong kopek 6.620 mg/kg,  terong gelatik 0 mg/kg) and Solanum quitoense L (terong asam  3.445 mg/kg). Terdapat perbedaan kandungan penting yang dapat mengurangi kadar asam sianida dalam Solanum melongena L dan Solanum quitoense L.   Kata kunci: Solanum melongena dan Solanum quitoense L, Asam Sianida

ISOLASI DAN KARAKTERISASI SENYAWA TERPENOID DARI DAUN Macaranga beccariana Merr.

JURNAL KIMIA MULAWARMAN Vol 16 No 1 (2018)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Abstract

Isolasi dan karakterisasi senyawa terpenoid dari fraksi etil asetat Macaranga beccariana Merr. telah dilakukan. Proses pemisahan pada fraksi etil asetat menggunakan kromatografi kolom gravitasi dengan metode elusi gradien. Isolat yang diperoleh diuji kemurniannya dengan menggunakan kromatografi lapis tipis dengan berbagai eluen yaitu n-heksana, kloroform, metanol, aseton dan etil asetat dengan nilai Rf secara berturut-turut yaitu 0; 0,75; 0,80; 0,87 dan 0,97. Senyawa terpenoid yang berhasil diisolasi berbentuk kristal putih dengan massa 0,0119 gram. Analisis dengan UV menghasilkan 1 puncak pada l 207,03 nm. Analisis senyawa dengan FT-IR mengindikasikan gugus fungsi -OH, C-H alifatik, C=C alifatik, C-O dan C=O. Berdasarkan dari hasil spektrum UV dan FT-IR maka senyawa isolat diduga mengandung senyawa terpenoid.

SCREENING BACTERIAL OF ENDOPHYTIC PRODUCING AMYLASE, LIPASE AND PROTEASE FROM LEAVES OF Macaranga hullettii King ex Hook.f.

JURNAL ATOMIK Vol 3 No 2 (2018)
Publisher : Jurusan Kimia FMIPA UNMUL

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Abstract

The objective of this study was to screening test of endophytic bacteria producing amylase, lipase and protease from leaves Macaranga hullettii King ex Hook.f. Endophytic bacteria isolation was performed on nutrient agar (NA) and 21 single colonies of endophytic bacteria were obtained. Endophytic bacteria that all of the endophytic bacteria positive producing enzym, 8 of the endophytic bacteria positive amylase, 7 of the endophytic bacteria positive lipase and 4 of the endophytic bacteria positive protease.  

PHYTOCHEMICAL TEST ON METHANOL EXTRACT OF LEAF OF Macaranga hullettii King ex Hook.f.

JURNAL ATOMIK Vol 3 No 2 (2018)
Publisher : Jurusan Kimia FMIPA UNMUL

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Abstract

Uji Fitokimia Macaranga hullettii King ex Hook.f telah dilakukan. Penelitian ini bertujuan untuk mengetahui metabolit sekunder menggunakan Kromatografi Lapis Tipis  dari ekstrak metanol pada daun Macaranga hullettii. Berdasarkan hasil skrining fitokimia, diketahui bahwa ekstrak metanol mengandung senyawa alkaloid, steroid/triterpenoid, polifenol dan flavonoid.