Akhmad Edy Purwoko, Akhmad Edy
Bagian Farmakologi, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Muhammadiyah Yogyakarta

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Efektifitas Antibiotik Golongan Sefalosporin dan Kuinolon terhadap Infeksi Saluran Kemih Triono, Aviv; Purwoko, Akhmad Edy
Jurnal Mutiara Medika Vol 12, No 1 (2012)
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (195.476 KB)

Abstract

Infeksi Saluran Kemih (ISK) adalah istilah yang dipakai untuk menyatakan adanya invasi mikroorganisme pada saluran kemih. jika tidak diterapi dengan baik, ISK dapat menyebabkan komplikasi berupa infeksi ascenden dan dapat menyerang organ ginjal. Pengobatan infeksi saluran kemih menggunakan antibiotik. Antibiotik yang digunakan untuk terapi ISK diantaranya adalah antibiotik golongan sefalosporin dan kuinilon. Penelitian ini bertujuan untuk mengetahui efektifitas antara penggunaan antibiotik golongan sefalosporin dibandingkan golongan kuinolon pada kasus infeksi saluran kemih berdasarkan lama perawatan di bangsal rawat inap RS Kabupaten Tegal. Desain penelitian adalah penelitian observasional dengan pendekatan case control. Subyek penelitian adalah data sekunder berupa rekam medik pasien rawat inap dengan diagnosis infeksi saluran kemih yang menggunakan pengobatan antibiotik golongan sefalosporin dan golongan kuinolon di Rumah Sakit. Jumlah sampel tiap kelompok adalah 42 sampel. Hasil penelitian didapatkan bahwa lama perawatan ISK menggunakan terapi antibiotik golongan sefalosporin 4.57 ± 2.07 hari, dan lama perawatan menggunakan antibiotik golongan kuinolon 3.95 ± 1.51 hari. Kedua kelompok perbedaaan tidak bermakna ditunjukkan dengan uji statistik Mann whitney ( p>0.05). Disimpulkan bahwa efektivitas lama perawatan pasien ISK dengan antibiotik golongan sefalosporin dan kuinolon tidak ada perbedaan yang bermakna.Urinary tract infection (UTI) is a common term which usually use to represent that there is an invasion of the microorganism in urinary tract. If it does not been treated well, UTI will cause complication like ascenden infection and it can make kidney failure. The therapy for UTI used antibiotic. Antibiotic which used to treat UTI are cephalosporin and quinolon. The study aims to determine the effectiveness between cephalosporin group of antibiotic use compared the quinolone group in the case of urinary tract infection based on duration of treatment in hospital Tegal. The design is an observational study with case control approach. The subjects are a secondary data from medical record of the hospitalization patients with urinary tract infection as their diagnose who have been treated by antibiotic with cephalosporin and quinolon group. The number of the samples for every group are 42 samples. The result of this research showed the duration for UTI treatment use cephalosporin is 4.57 ± 2.07 days and the duration for UTI treatment use quinolon is 3.95 ± 1.51 days. From aboth of that group show there is no significance value which it is showed by Mann Whitney (p>0,05). It was concluded that the effective duration for UTI therapy among cephalosporin with quinolon there is no significance difference.
Effect of Soybean-based Food Supplement on Insulin and Glucose Levels in Type 2 Diabetes Mellitus Patients Purwoko, Akhmad Edy; Astuti, Indwiani; Asdie, Ahmad Husain; Sugiyanto, Sugiyanto
Indonesian Journal of Pharmacy Vol 30 No 3, 2019
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjpharm30iss3pp208

Abstract

Introduction: Indonesia is one of ten countries with the largest diabetic populations in the world. Giving soy supplements to people with diabetes can reduce blood glucose levels significantly. However, no studies have shown a reduction back to normal glucose levels. This study aimed to determine the increase of insulin levels and blood glucose suppression in glucose tolerance tests after supplementation of soy in patients with type 2 diabetes. Sequencing the gene of GLP-1 (37 amino acid). This experimental research was a randomized, treatment controlled; open clinical trial study conducted by comparing the control group treated with soybean supplement products containing 18g protein and placebo. Seventy-six treatment subjects with type 2 diabetes were recruited from Muhammadiyah Gamping Hospital and PERSADIA gymnastics group according to the inclusion and exclusion criteria and then grouped randomly in the supplement treatment and placebo groups. Blood sampling was drawn at 8 hours fasting, 2 hours after supplement administration and 2 hours after administration of 75g glucose for measuring blood insulin and glucose level. Blood insulin level 2 hours after supplement administration (mean±SEM) increased 5.3±0.8µIU/ml (n=37) while placebo decreased 0.9±0.4µIU/ml (n=39) which was statistically significantly different (p<0.05). Blood glucose levels increased in the glucose tolerance tests, while the supplement group was 130.0±11.5mg/dl (n=37) lower than the placebo 146.7±8.2mg/dl (n=39) (p>0.05). Gene sequencing shows a nucleotide variation of GLP-1 (37 amino acid) in Javanese T2DM Giving Soybean supplements containing 18g protein increased blood insulin levels and suppressed blood glucose levels in glucose tolerance tests.