Sahidin I, Sahidin
Study of chemistry, Faculty of Mathematics and Natural Sciences, Universitas Haluoleo Kendari. Southeast Sulawesi, Indonesia.

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Identification and determination of traditional medicinal plants of Southeast Sulawesi People at Arboretum Prof. Mahmud Hamundu Haluoleo University

INDONESIAN JOURNAL OF PHARMACY Vol 19 No 2, 2008
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

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Abstract

Seventeen traditional medicinal plants of South East Sulawesi are collected at Arboretum Prof. Mahmud Hamundu Universitas Haluoleo, have been determined successfully by Herbarium Bogoriense staffs, Cibinong Bogor. The plants came from Konawe and KonaweSelatan districts. Endemicity of those plants as medicinal plants were based on ethnobotanical study using information from “Tokoh Masyarakat Tolaki” and “Tokoh Masyarakat Jawa”. Collected traditional medicinal plants at those places, but have not known in Java, are assumed as specialized plants of Tolakinese. All of the plants were determined at Herbarium Bogoriense. Moreover, detailed study of those plants including biology, chemistry and pharmacy aspects were done by electronically literatures study using science direct programmed. According to the literatures, Sterculea cf. oblongata R.Br. and Talinum triangulare Willd have not been reported the research yields. Key words: Traditional medicinal plants, Konawe, Konawe Selatan, and Tolakinese.

Isolasi dan Identifikasi Jatrophone dari Akar Jarak Merah (Jatropha gossyptfolia) serta Evaluasi Sifat Toksik dan Sitotoksiknya

JURNAL ILMU KEFARMASIAN INDONESIA Vol 8 No 2 (2010): JIFI
Publisher : Fakultas Farmasi Universitas Indonesia

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Abstract

Isolasi dan identifikasi senyawa metabolit sekunder dari akar jarak merah (Jatropha gossypyfolia), serta uji sifat toksik terhadap mikroba dan sitotoksiknya terhadap sel tumor telah dilakukan, Isolasi senyawa dikerjakan dengan menggunakan kromatograti kolom vakum (adsorben: silica gel, eluen: campuran n-heksan, etilasetat, kloroform, dan metanol). Identifikasi struktur dilakukan menggunakan teknik spektroskopi (F TIR, NMR-1 D,13C/DEPT, NMR-2D) dan membandingkan data tersebut dengan data sejenis yang telah dilaporkan. Sifat toksik dievaluasi terhadap bakteri Acetobacter sp., Eschericia coli, Staphylococcus aureus, dan Streptococcus sp., jarnur Aspergilus niger, Penicillium (grey), Penicillium sp. (wliite) dan Rlzizopus sp., serta sitotoksik pada sel murine leukemia P-388. Isolat yang diperoleh berupa kristal berbentuk jarum berwarna putih dan teridentifikasi sebagai jatrophone. Jatrophorie paling kuat menghambat pertumbuhan bakteri Acetobaclcr sp. dengan zona hambat 3,6 cm dan paling aktif terhadap fungi A. niger dengan zona hambat 4,4 cm. Sementara itu, sifat sitotoksiknya terhadap sel murine leukemia P-388 memperlihatkan sifat kurang aktif dengan nilai IC50 > 100 µg/mL.