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Pengaruh Kadar Feritin Serum terhadap Fungsi Ventrikel Kiri pada Thalassemia Mayor yang Mendapat Transfusi Multipel

Sari Pediatri Vol 9, No 3 (2007)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

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Abstract

Latar belakang. Thalassemia adalah penyakit darah yang bersifat diturunkan, transfusi darah secara teraturmerupakan satu-satunya cara untuk memperpanjang hidup.Tujuan. Untuk mengetahui pengaruh kadar feritin serum terhadap fungsi ventrikel kiri pada pasienthalassemia mayor yang mendapatkan transfusi multipel.Metode. Penelitian dengan rancang bangun cross sectional. Dilakukan di Divisi Hematologi - OnkologiRS Dr Sutomo Surabaya dari bulan Agustus-November 2006. Pengambilan sampel secara konsekutif,dibagi menjadi 3 kelompok berdasarkan jumlah transfusi darah yang telah diterima.Hasil. Subjek penelitian 61 anak rerata kadar serum feritin pada kelompok 1: 768,7, kelompok 2: 2338,8,kelompok 3: 5207,3. Hasil ekokardiografi EF < 64% kelompok 1: 3 dari 18 anak (16,7%), kelompok 2: 2dari 15 anak (13,3%), kelompok 3: 8 dari 28 anak (28,6%). Rasio E/A < 1,5 kelompok 1: 6 dari 18 anak(33,3%), kelompok 2: 3 dari 15 anak (20,0%), kelompok 3: 12 dari 28 anak (42,9%). Rasio E/A > 2,5kelompok 1: 1 dari 18 anak (5,6%), kelompok 2: 1 dari 15 anak (6,7%), kelompok 3: 4 dari 28 anak(9,8%). Dengan analisis regresi logistik, ternyata tidak ada hubungan bermakna antara kadar feritin serumdengan gangguan fungsi ventrikel kiri pada subyek penelitian. (p > 0,05)Kesimpulan. Terdapat hubungan antara lama transfusi dengan rasio E/A yang > 2,5, namun tidakdidapatkan hubungan antara kadar serum feritin dengan gangguan fungsi ventrikel kiri pada pasientallasemia mayor yang mendapatkan transfusi secara multipel.

Correlation between Serum Ferritin and Cardiac Troponin I in Major Beta Thalassemia Children

Journal of Tropical Life Science Vol 6, No 1 (2016)
Publisher : Journal of Tropical Life Science

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Abstract

Background: Major beta thalassemia (MBT) is a hereditary disease which synthesis defect on beta chains of haemoglobin, it is cause red blood cell destruction and the symptoms of anemia. Red blood cells destruction, frequent blood transfusion and low adherence to routine use of iron chelator were cause iron accumulation in the heart, liver and endocrine organs. Accumulation of iron in the myocard can lead acute myocardial infarction. One of cardiac markers that had been used for the diagnosis of myocardial infarction was cardiac troponin I (cTnI). The aim of this research is find correlation between serum ferritin levels and cTnI in MBT children.Methods: A descriptive analytic research was conducted using a cross sectional design. The subjects were divided into 2 groups, the MBT group and the control group. In both groups perform laboratory examination to checks the serum ferritin and cTnI levels. Data were analyzed using t-test and Pearson correlation test.Result: Eleven children in the MBT group and 11 children in the control group were involved in this study. In the MBT group, the mean of serum ferritin and cTnI levels were 4292.5 μg/L and 0.22 ng/mL respectively. In the control group, the mean of serum ferritin and cTnI levels were 136.2 μg/L and 0.20 ng/mL respectively. The mean of serum ferritin levels in MBT group was higher than control, statistically significant (p= 0,0004 ). The mean of serum cTnI in MBT group was higher than control, statistically not significant (p= 0,82). In MBT group, there was a weak corellation between serum ferritin and cTnI levels (r = 0,34). Keywords: Major beta thalassemia, children, ferritin, cTnI

Prominently Increased of Mannose Binding Lectin (MBL) and Myeloperoxidase (MPO) Levels in Severe Valve Regurgitation and Heart Failure of Rheumatic Heart Disease

Journal of Tropical Life Science Vol 7, No 2 (2017)
Publisher : Journal of Tropical Life Science

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Abstract

Rheumatic heart disease (RHD) is mediated by an abnormal immunological response following a Streptococcus pyogenes infection that induces a disturbance of oxidants and antioxidants balances. Mannose-binding lectin (MBL) binds to N-acetylglucosamine, a molecule present on the Streptococcus cell wall and human heart valves. There is a disturbance of oxidant and antioxidant balance in rheumatic disease. Myeloperoxidase (MPO) is a marker of oxidative stress and inflammation. This study was aimed to determine the correlation of MBL and MPO levels and severity of valvular regurgitation and heart failure (HF) in RHD patients. A case-control study was conduct using human peripheral blood samples from 32 children aged 6 to 14 years old. The subjects were divided into two groups: 16 RHD patients included in the case group and 16 healthy children as a control group. The level of MBL and MPO was investigated using ELISA method. There were significant differences on MBL and MPO level between patient and control group. The level of MBL and MPO were significantly increased in RHD group, especially on severe valvular regurgitation. There was a strong correlation between MBL and MPO levels and the severity of valvular regurgitation (r = 0.94 and r = 0.88). The least significant diff-erence (LSD) analysis showed that significant difference occurs in the severe heart failure group. Our research revealed that the MBL and MPO levels in pediatric RHD patients were significantly higher than in healthy children. The MBL and MPO levels were significantly correlated with the severity of valvular regurgitation and heart failure.