AL. Supartinah, AL.
Department of Paediatric Dentistry, Faculty of Dentistry, Universitas Gajah Mada
Articles
2
Documents
THE INFLUENCE OF NIFEDIPINE INDUCTION TO GINGIVAL EPITHELIAL CELL PROLIFERATION (in vivo study in rat)

Journal of Dentistry Indonesia Vol 11, No 1 (2004): April
Publisher : Faculty of Dentistry, University of Indonesia

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Abstract

It is well known that nifedipine administration in hypertensive patients results in gingival hyperplasia. The aim of this study was to study the pattern of nifedipine-induced gingival hyperplasia, based on morphometric and histogical changes as well as on PCNA (Proliferating Cell Nuclear Antigen) expression in the gingival epithelium. In total, 36 male Sprague Dawley rats at the age of 6-8 weeks were divided into nine experimental groups and three control groups. Each animal received daily DMSO (dimethyl sulfoxide) via oral intubation at a dosage of 0 (for control groups), 15, 30, or 60 mg/kg (experimental groups) of body weight for 7, 21 or 42 days. After the animals were sacrificed, impression of the lower gingival tissue was taken to measure mesio-distal distance, labio-lingual distance and papilla height. The number of blood vessels and the thickness of gingival epithelium were assessed from hematoxylin and eosin stained sections. Proliferative activity of the epithelial cells was determined by immunohistochemical analysis using PCNA monoclonal antibody. Significant increase in the mesio-distal and labio-lingual distance of the lower gingival tissue was detected morphometrically (p<0.05). There were more blood vessels in the experimental groups than in the control groups, however there was no specific pattern based on the dosage or duration of nifedipine administration. On the other hand, significant differences were found in the gingival epithelial thickness and proliferative activity between the experimental and the control groups. PCNA-positive cells were observed in basal and suprabasal layers, but nearly none in lamina propria.

PENGARUH PENYULUHAN KONSUMSI MAKANAN KARIOGENIK PADA IBU DAN ANAK TERHADAP KEPARAHAN KARIES SISWA TAMAN KANAK-KANAK (Kajian Pada Siswa Taman Kanak-Kanak di Kecamatan Kasihan Kabupaten Bantul)

ODONTO : Dental Journal Vol 2, No 1 (2015): July 2015
Publisher : Fakultas Kedokteran Gigi

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Abstract

Background: Prevention of caries in preschool children is influenced by role of mothers. In reality lots of mothers do not pay much attention in maintaining the children’s teeth. Purpose: The study aimed to find out the effect of socialization on cariogenic food consumption in mothers and children to dental and caries severity of children at kindergartens at Subdisctrict of Kasihan District of Bantul. Method: The study was a quasi experiment with Two Group Pre-Test Post-Test Design. Samples were determined through cluster sampling technique, comprising as many as 136 pairs of mothers and children in three kindergartens at the area of Subdistrict of Kasihan, District of Bantul. The study was focused on the effect of socialization on cariogenic food consumption to knowledge of children, knowledge of mothers, mothers’ behavioral tendencies and dental and oral health statcaries severity of children. Data the knowledgeof children, knowledge of mothers and mothers’ behavioral tendencies were assessed using questionaire, and CIS as caries severity index and analyzed using paired t-test and independent t-test. Conclusion: Socialization in group of mothers and children increased knowledge of children, knowledge of mothers, behavioral tendencies of mothers than in group of children. Socialization in group of mothers and children and group of children did not decrease severity of dental cariesKeywords: socialization, cariogenic foods, preschool children, caries severity