Eriawan Agung Nugroho, Eriawan Agung
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The Efficacy of Dutasteride and Green Tea Combination Towards Angiogenesis and Bleeding on BPH after TURP : Study their effect on VEGF, MVD and Hb Nugroho, Eriawan Agung; Muslim, Rifki; Riwanto, Ignatius; Pranoto, Soetojo Wirjo
International Journal of Science and Engineering Vol 9, No 2 (2015)
Publisher : Chemical Engineering Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (978.937 KB) | DOI: 10.12777/ijse.9.2.80-84

Abstract

ABSTRACT Objectives: to find the efficacy dutasteride and green tea in reducing hemorrhage on TURP patients  and to evaluate the anti- angiogenesis effect. Methods: Double Blind Randomized Controlled Trial Post Test Only, with 80 samples, randomized into 4 groups: 1 control group and 3 treatment groups (P1 with 0.5 mg of dutasteride, P2 with a capsul of green tea, and P3 with combination of 0.5 mg dutasteride and a capsul green tea at least 14 days before TURP. We compared the ΔHb define the VEGF expression and MVD count to evaluate the angiogenesis changes between 4 groups. The difference is considered statistically significant with p<.05. Results: ΔHb (-0.40 + 0.246) pg/ml for control group, (-0.20 + 0.067) pg/ml for P1 group, (-0.18 + 0.081) pg/ml for P2 group, and (-0.14 + 0.092) pg/ml for P3 group. VEGF expression were (20.20 + 17.386), (12.90 + 15.509), (11.60 + 9.121), and (3.60 + 1.667) for control, P1, P2, and P3 group respectively. MVD count were (41.20  + 10.273), (32.75 + 9.318), (26.15 + 7.278), and (18.35 + 7.876) for control, P1, P2, and P3 group respectively. The result from between-subject effect tests showed statistically significant differences in ΔHb (p<0.001), VEGF expression (p<0.001), and MVD count (p<0.001). Dutasteride and green tea significantly reduce the hemorrhage during TURP by decreasing the MVD. Conclusion: Administration of  0.5 mg dutasteride and 725 mg of green tea, 14 days prior to TURP significantly reduce the hemorrhage during TURP (Δ Hb) by decreasing the MVD
Perbandingan Kadar Estrogen Serum dan TGF β-1 Plasma pada Penderita BPH-Non BPH di Atas 50 Tahun dan Usia Muda Nugroho, Eriawan Agung; Budijitno, Selamat
MEDIA MEDIKA INDONESIANA 2013:MMI VOLUME 47 ISSUE 1 YEAR 2013
Publisher : MEDIA MEDIKA INDONESIANA

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ABSTRACT Comparison of estrogen serum and TGF β-1 plasma levels in benign prostate hyperplasia (BPH) and non BPH patients, among 50-years old and young patients.Background: Benign prostatic hyperplasia (BPH) is often found in older men. This disease affects an estimated 70% of men over 60 years, increased by 90% in men over 80 years age. Many scientists tried explores the hypothesis of the mechanism of occurrence of BPH. The purpose of study compared the levels of estrogen and transforming growth factor (TGF) ß-1 in plasma related to the development of BPH, in BPH patients and non-BPH over 50 years and young age.Methods: A clinical analysis study was carried out on subjects who were divided into 3 groups: patients with BPH >50 years, non-BPH >50 years and younger non-BPH aged 30-40 years. T-test was used to analyze the data. Serum estrogen and plasma TGF β-1 were assessed using ELISA method.Results: There was no significant difference (p=0.129) between the level of estrogen in BPH patients >50 years (140.091±43.649) and non BPH patients >50 years (63.69±18.757) but there was a significant difference (p=0.015) between level of plasma TGF ß-1 BPH patients >50 years (10.47±4.507) and non BPH patients >50 years of age (25.8±16.1103). No significant differences (p=0.348) were found between serum estrogen level of non-BPH >50 years (63.69±18.757) and the young age (57.17±10.2748), and between plasma TGF ß-1 non-BPH group >50 years (25.80±16.1103) and the younger age group (31.4±17,576)(p=0.496).Conclusion: There is difference in the level of TGF ß-1 between younger and older age groups. Elderly men are recommended for early prostate examination, because at the age of 50 years there is already a tendency of enlarged prostate gland. Levels of transforming growth factor β-1 can predict prostate enlargement.Keywords: Estrogen, TGF ß-1, benign prostate hyperplasia (BPH)ABSTRAKLatar belakang: Benign prostate hyperplasia (BPH) sering ditemukan pada pria usia lanjut. Penyakit ini terjadi pada 70% pria di atas 60 tahun, dan meningkat hingga 90% pada pria di atas 80 tahun. Banyak ilmuwan mencoba mengetengahkan hipotesis faktor yang berpengaruh terjadinya BPH. Tujuan penelitian ini membandingkan tingkat estrogen dan transforming growth factor (TGF) ß-1 dalam plasma terkait pembentukan BPH.Metode: Penelitian klinik analitik dilakukan pada subyek yang dibagi 3 kelompok, pasien dengan BPH >50 tahun, pasien non-BPH berusia >50 tahun dan muda non-BPH berusia 30-40 tahun. Analisis data dengan uji beda kadar estrogen serum dan TGF β-1 plasma ketiga kelompok. Kadar TGF ß-1 dan estrogen diukur dengan metoda ELISA.Hasil: Serum estrogen pasien BPH usia >50 tahun (140,091±43,649) lebih tinggi tetapi tidak berbeda bermakna (p=0,129) dibandingkan non BPH usia >50 tahun (63,69±18,757). Estrogen serum non-BPH usia >50 tahun (63,69±18,757) dibandingkan usia muda (57,17±10,2748) tidak berbeda bermakna (p=0,348). TGF ß-1 plasma pasien BPH usia >50 tahun (10,47±4,507) lebih rendah (p=0,015) dibandingkan pasien non BPH usia >50 tahun (25,8±16,1103). TGF ß-1 plasma kelompok non-BPH >50 tahun (25,80±16,1103) dibandingkan kelompok usia muda (31.04±17,576) tidak berbeda bermakna (p=0,496).Simpulan: Ada perbedaan antara tingkat TGF β-1 pada kelompok yang lebih tua. Laki-laki usia tua disarankan lebih dini melakukan pemeriksaan prostat, usia >50 tahun cenderung didapatkan pembesaran kelenjar prostat. Pemeriksaan kadar TGF -1 dapat memprediksi risiko pembesaran kelenjar prostat.
Hospital Waste Management in Kidney Transplantation Procedure: Implications and Solutions Nugroho, Eriawan Agung; Nugroho, Leonardo Cahyo
Waste Technology Vol 7, No 1 (2019)
Publisher : Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12777/wastech.7.1.%p

Abstract

The number of patients diagnosed with end-stage renal disease (ESRD) in Indonesia is increasing annualy, showing a similar trend with the global prevalence. Withits superior outcome, kidney transplantation remains to be the traetment of choice for ESRD. The treatment with transplant kidney procedure makes extensive use of presterilized disposable items which, after use, are contaminated by blood. The preferred route of disposal of such items is by incineration. Disposal costs have risen and this increase in costs has not been matched by waste management programs in kidney transplantation procedure. Many of the waste items like container for blood products and intravenous infusion fluid contain erwhichiswidely used in kidney transplantation procedure generated alsoconta in polyvinylchloride (PVC) whose incineration is environmentally sensitive. Furthermore blood tubing sets contain plasticizers such as di(2-ethylhexyl) phthalate (DEHP), which is known to pose health risks to specific groups of patients. The generation of hospital waste in a kidney transplantation procedure is analyzed, issues associated with disposal are discussed, and approaches toward a cost effective environmentally sustainable hospital waste management program are reviewed.
The Correlation between Total Ischemic Time with Length of Hospitalization : a Single Centre Report Nugroho, Eriawan Agung; Kamar, Muhamad Azwin; Junita, Dila
International Journal of Science and Engineering Vol 13, No 1 (2019)
Publisher : Chemical Engineering Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (771.544 KB) | DOI: 10.12777/ijse.13.1.%p

Abstract

Kidney transplantation is recognized as an advanced modern therapeutic modality for patients with end stage renal failure. Cold Ischemic Time (CIT) has been found as an important independent risk factor for delay graft function (DGF) in kidney transplantation. Recent studies suggested that prolonged Warm Ischemic Time (WIT) may decrease graft’s survival in living kidney transplantation donor.This study aimed to evaluate the total ischemic time during recipient surgery and accessed its contribution for hospitalization time in kidney transplantation patients.This is an observational, cross sectional study. The datawas collected from medical record of patient who underwent kidney transplantation from 2014 until December 2018at Kariadi General Hospital Semarang. There were 28 patients, 18 were maleand 10 were female.Total ischemic time was compared with length of hospitalization. Data was analyzed with Spearman test in SPSS version 23. The study showed that total ischemic time was significantly correlated with hospitalization time (p < 0.001). However, donor’s age did not affect prolonged total ischemic time with p = 0.673, which is not significant (significant if p value < 0.05). In conclusion, total ischemic time has a significant correlation with hospitalization time. In contrary, no significant correlation between donor’s age and prolonged total ischemic time.
Kidney Transplantation in Semarang: Outcomes and Prognosis Nugroho, Eriawan Agung; Supit, Tommy; Santosa, Ardy; Daniswara, Nanda; Addin, Sofyan Rais; Mukti, Anggun Ari
Medica Hospitalia : Journal of Clinical Medicine Vol 6 No 1 (2019): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (248.003 KB) | DOI: 10.36408/mhjcm.v6i1.381

Abstract

Introduction &amp; objective:Kidney transplantationis increasingly performed acrossIndonesia, including in Semarang. However there are limited publications onrenal transplantationfrom Indonesia, especially from centers outside Jakarta. The objective of this case series is to give a brief overview on the transplantation performed in Semarang, discusscurrent issues and ongoing efforts to address them. Case series:Twenty-seven renal transplants in Dr. Kariadi General Hospital from January2012 until July 2018wereretrospectively analyzed. On average recipients were younger (32.5 years old) compared to the donors (46.8 years old). All kidneys were acquired from living donors with the majority of them to be blood-related(74.1%). The 3 leading etiologies of end-stage renal disease were hypertension (36.0%), diabetes mellitus (26.9%), and autoimmune disease (11.2%). The average total ischemic time was 36.9 minutes andthe average length of stay was 11 days. We report 5 cases of mortality, 3 cases of allograft rejection and no re-transplantation. Discussion: The demographics of kidney transplant patients in Semarang were similar compared to the National data. The limited number of transplant in Semarang contributes to the low number of survival rate and highlights the need of further training and expertise. Better survival rate can be achieved with more transplants number as well as reaching the plateau of learning curve within the coming years. Conclusion: The development of kidney transplant in Semarang follows the National milestones. In order to maximize the potentialthe institution, further improvements should concentrate on the development of integrated organ transplant infrastructure. The main goal of this institution is to establish a solid transplant center capable of covering Central Java, aiding the decentralization of kidney transplant in the Nation Keywords: Kidney transplantation, End-stage Renal Disease, Chronic Kidney Disease, Indonesia, Semarang, Epidemiology, Update