Dhani Redhono, Dhani
Sub Division Tropical Medicine & Infectious Disease Faculty of Medicine, Sebelas Maret University, Moewardi Hospital

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Relationship Between Clinical Manifestations and Antibody Serum in Outbreaks Anthrax Redhono, Dhani
Indonesian Journal of Tropical and Infectious Disease Vol 5, No 5 (2015)
Publisher : Institute of Topical Disease

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Abstract

Introduction: Anthrax is a zoonotic disease that often affects the grass-eating animals, which occurs due to the entry of spores into the bodies of animals and can be transmitted to humans. This disease often appear in certain seasons and occurs in endemic areas, including Indonesia. Cutaneous anthrax is the clinical manifestations that often arise on outstanding events in the area. This study aims to determine how the relationship between the clinical manifestations of the serum antibodies in people who are exposed to anthrax. Material and methods: This study is an observational cross sectional analytic approach, in people exposed to anthrax to assess the clinical manifestations and antibody serum Anthrax. Results: Obtained in this study respondents were 101 people with a history of contact with animals suffering from anthrax. The number of respondents with the highest age distribution was 31 to 40 years by 42%, and most were female gender, which is 57.7%, the highest level of education is 74% finished elementary school. Forty-four percent of working as a housewife. Risk factors are the most direct contact with and consume the flesh of animals as much as 34.6%. Results of Ig G antibody serum showed 50% negative, 15.4 borderline and 34.6% positive. Clinical manifestations that occur in the skin as much as 13.5%, that is the eschar on all respondents and 92.8% showed positive Ig G. While 86.5% did not show any clinical signs of anthrax, of that number 25.5% with Ig G positive, 16.6% and 57.7% showed borderline negative with p 0.02. Conclusion: There was a significant association between the clinical manifestation with antibody serum anthrax. But also found apositive Ig G without the appearance of clinical signs in the skin.
RELATIONSHIP BETWEEN CLINICAL MANIFESTATIONS AND ANTIBODY SERUM IN OUTBREAKS ANTHRAX Redhono, Dhani
Indonesian Journal of Tropical and Infectious Disease Vol 5, No 5 (2015)
Publisher : Institute of Topical Disease

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (487.023 KB) | DOI: 10.20473/ijtid.v5i5.303

Abstract

Introduction: Anthrax is a zoonotic disease that often affects the grass-eating animals, which occurs due to the entry of spores into the bodies of animals and can be transmitted to humans. This disease often appear in certain seasons and occurs in endemic areas, including Indonesia. Cutaneous anthrax is the clinical manifestations that often arise on outstanding events in the area. This study aims to determine how the relationship between the clinical manifestations of the serum antibodies in people who are exposed to anthrax. Material and methods: This study is an observational cross sectional analytic approach, in people exposed to anthrax to assess the clinical manifestations and antibody serum Anthrax. Results: Obtained in this study respondents were 101 people with a history of contact with animals suffering from anthrax. The number of respondents with the highest age distribution was 31 to 40 years by 42%, and most were female gender, which is 57.7%, the highest level of education is 74% finished elementary school. Forty-four percent of working as a housewife. Risk factors are the most direct contact with and consume the flesh of animals as much as 34.6%. Results of Ig G antibody serum showed 50% negative, 15.4 borderline and 34.6% positive. Clinical manifestations that occur in the skin as much as 13.5%, that is the eschar on all respondents and 92.8% showed positive Ig G. While 86.5% did not show any clinical signs of anthrax, of that number 25.5% with Ig G positive, 16.6% and 57.7% showed borderline negative with p 0.02. Conclusion: There was a significant association between the clinical manifestation with antibody serum anthrax. But also found a positive Ig G without the appearance of clinical signs in the skin.
Anthrax Seroprevalence in Central Java, Indonesia Redhono, Dhani; Dirgahayu, Paramasari
Indonesian Journal of Medicine Vol 1, No 2 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Anthrax is a zoonotic disease that is caused by Bacillus Anthracis is transmitted to humans through infected animal. The transmission to humans occurs when there is a contact to animals or animal products contracting anthrax. Clinical skin manifestations and anthrax serum Ig G antibody can be used to diagnose infected anthrax animals. This study aimed to determine the prevalence of anthrax based on ELISA serum Ig G antibody and clinical skin manifestations occurring in patients with anthrax.Subjects and Method: This was a descriptive study with cross sectional design conducted in Sragen district, Central, Indonesia, in 2015. A sample of 101 patients infected with anthrax was examined based on clinical skin manifestations and anthrax serum Ig G antibody.Results: 39.6% of the sample was 21 to 40 years of age. 57.4% of the sample was female. 74% of the sample completed primary school. 21% worked as farmers. 30.5% of the sample who cooked and consumed meat showed positive Ig G. Test results showed serum Ig G antibody negative 50%, 15.8% and 33.7% borderline positive. Clinical manifestations in the skin as much as 11.9%, which is the eschar on all respondents and 92.8% showed positive Ig  G. While 88.1% did not show any clinical signs of anthrax.Conclusion: The increase in serum antibody titer Ig G anthrax is not all respondents were exposed, in an area that otherwise outbreak of anthrax, which is only a third of all respondents, and when it comes up eschar will be followed by an increase in Ig G antibody titer.Keywords: cutaneous anthrax, Ig G antibody ELISA, escharCorrespondence: Dhani Redhon. Sub Division Tropical Medicine and Infectious Disease, Internal Medicine.Indonesian Journal of Medicine (2016), 1(2): 129-135https://doi.org/10.26911/theijmed.2016.01.02.07