Articles
5
Documents
PATHOGENESIS OF HEMORRHAGIC DUE TO DENGUE VIRUS

Indonesian Journal of Tropical and Infectious Disease Vol 5, No 4 (2014)
Publisher : Institute of Topical Disease

Show Abstract | Original Source | Check in Google Scholar

Abstract

Dengue is a viral disease that is mediated by a mosquito, which causes morbidity and mortality. Viruses can increase vascular permeability which can lead to hemorrhagic diathesis or disseminated intravascular coagulation (DIC) known as dengue hemorrhagic fever (DHF). In Indonesia, dengue hemorrhagic fever (DHF) are caused by dengue virus infection which was found to be endemic accompanied by an explosion of extraordinary events that appear at various specified period. The diagnosis of dengue is determined based on the criteria of the World Health Organization (WHO, 1999), which are sudden high fever accompanied by a marked tendency to hemorrhage positive tourniquet test, petechiae, ecchymosis, purpura, mucosal hemorrhagic, hematemesis or melena and thrombocytopenia. The problem that still exists today is the mechanism of thrombocytopenia in patients with varying degrees of dengueinvolving levels of vWF (von Willebrand factor) and prostaglandin I2 (PGI2) can not be explained. The mechanism of hemorrhagic in dengue virus infections acquired as a result of thrombocytopenia, platelet disfunction decreased coagulation factors, vasculopathy with endothelial injury and disseminated intravascular coagulation (DIC).

PATHOGENESIS OF HEMORRHAGIC DUE TO DENGUE VIRUS

Indonesian Journal of Tropical and Infectious Disease Vol 5, No 4 (2015)
Publisher : Institute of Topical Disease

Show Abstract | Original Source | Check in Google Scholar

Abstract

Dengue is a viral disease that is mediated by a mosquito, which causes morbidity and mortality. Viruses can increase vascular permeability which can lead to hemorrhagic diathesis or disseminated intravascular coagulation (DIC) known as dengue hemorrhagic fever (DHF). In Indonesia, dengue hemorrhagic fever (DHF) are caused by dengue virus infection which was found to be endemic accompanied by an explosion of extraordinary events that appear at various specified period. The diagnosis of dengue is determined based on the criteria of the World Health Organization (WHO, 1999), which are sudden high fever accompanied by a marked tendency to hemorrhage positive tourniquet test, petechiae, ecchymosis, purpura, mucosal hemorrhagic, hematemesis or melena and thrombocytopenia. The problem that still exists today is the mechanism of thrombocytopenia in patients with varying degrees of dengue involving levels of vWF (von Willebrand factor) and prostaglandin I2 (PGI2) can not be explained. The mechanism of hemorrhagic in dengue virus infections acquired as a result of thrombocytopenia, platelet disfunction decreased coagulation factors, vasculopathy with endothelial injury and disseminated intravascular coagulation (DIC).

Efek Angiogenesis Lumbrokinase terhadap Gambaran Histopatologi Jantung Tikus Galur Wistar Hipertensi Angiogenesis Effect of Lumbrokinase on the Cardiac Histopathology of Hypertensive Wistar Rat

Pustaka Kesehatan Vol 3, No 1 (2015)
Publisher : Pustaka Kesehatan

Show Abstract | Original Source | Check in Google Scholar | Full PDF (212.085 KB)

Abstract

Hypertension remains a serious health problem it is dubbed as “the silent killer”. Pathophysiology of hypertension involve alteration of vascular structure. The use of anti hypertension leads to many side effects, and many people tend to choose natural therapy. The study aimed to investigate the effect of lumbrokinase on angiogenesis as a hypertension therapy agent. In true experimental design, 22 males wistar rat were divided into control group and treatment group (Lumbrokinase 0.5 gr/KgBW/day). The results showed that the systolic blood pressure decrease after therapy with lumbrokinase from 187 mmHg to 159 mmHg whereas diastolic blood pressure consistant at 80 mmHg after induction of hypertension as well as therapy of lumbrokinase. An examination of cardiac histopathology, there was an increasing number of blood vessels in the treatment group, 10.55± 1.44 compared to 7.45± 1.21 in control group. It can be concluded that lumbrokinase had an angiogenesis effect and decrease systolic blood pressure in hypertensive rat model. Keyword : Hypertension, lumbrokinase, vascular structure, angiogenesis.

Efek Angiogenesis Beraprost terhadap Gambaran Histopatologi Jantung Tikus Galur Wistar Hipertensi (Angiogenesis Effect of Beraprost on the Cardiac Histopathology of Hypertensive Wistar Rat)

Pustaka Kesehatan Vol 3 No 3 (2015)
Publisher : UPT Penerbitan Universitas Jember

Show Abstract | Original Source | Check in Google Scholar | Full PDF (1912.411 KB)

Abstract

Hypertension is a state where there is an increase of blood pressure above normal threshold,120/80 mmHg. The phatophysiology of hypertension involves the changes of vascular structure. Therefore, the beraprost drug was created. It is a vasodilator and antitrombolytic which is able to induce angiogenesis. The study aimed to investigate the effect of Beraprost on angiogenesis as a hypertension therapy agent. In true experimental design, 22 males wistar rat were divided into control group and treatment group (Beraprost 100mcg/KgBW/day). The results showed that the systolic blood pressure decrease after therapy with Beraprost from 180 mmHg to 143 mmHg whereas diastolic blood pressure consistant at 80 mmHg after induction of hypertension as well as therapy of Beraprost. An examination of cardiac histopathology, there was an increasing number of blood vessels in the treatment group, 16.637.29 compared to 7.45 1.21 in control group. It can be concluded that Beraprost had an angiogenesis effect and decrease systolic blood pressure in hypertensive rat model. Keyword : Hypertension, Beraprost, vascular structure, angiogenesis.

Efek Angiogenesis Lumbrokinase terhadap Gambaran Histopatologi Jantung Tikus Galur Wistar Hipertensi Angiogenesis Effect of Lumbrokinase on the Cardiac Histopathology of Hypertensive Wistar Rat

Pustaka Kesehatan Vol 3 No 1 (2015)
Publisher : UPT Penerbitan Universitas Jember

Show Abstract | Original Source | Check in Google Scholar | Full PDF (212.085 KB)

Abstract

Hypertension remains a serious health problem it is dubbed as “the silent killer”. Pathophysiology of hypertension involve alteration of vascular structure. The use of anti hypertension leads to many side effects, and many people tend to choose natural therapy. The study aimed to investigate the effect of lumbrokinase on angiogenesis as a hypertension therapy agent. In true experimental design, 22 males wistar rat were divided into control group and treatment group (Lumbrokinase 0.5 gr/KgBW/day). The results showed that the systolic blood pressure decrease after therapy with lumbrokinase from 187 mmHg to 159 mmHg whereas diastolic blood pressure consistant at 80 mmHg after induction of hypertension as well as therapy of lumbrokinase. An examination of cardiac histopathology, there was an increasing number of blood vessels in the treatment group, 10.55± 1.44 compared to 7.45± 1.21 in control group. It can be concluded that lumbrokinase had an angiogenesis effect and decrease systolic blood pressure in hypertensive rat model. Keyword : Hypertension, lumbrokinase, vascular structure, angiogenesis.