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Djoko Trihadi, Djoko
Bagian Penyakit Dalam Fakultas Kedokteran Universitas Islam Sultan Agung (UNISSULA)

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Hyperexpression of TNF-Stimulated 6 (TSG-6) of HumanTracheal Aspirate and Bronchial Alveolar Lavage from Heavy-Smoker and Lung TB Trihadi, Djoko
Sains Medika Vol 3, No 1 (2011): Januari-Juni 2011
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

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Abstract

Background: TSG-6, an inflamation-associated protein, forms covalent complexes with heavy-chains from TNF. These protein potentiating the antiplasmin activity of this serine protease inhibitor. The aim of study was to determine and show that TSG-6 are present in Bronchoalveolar Lavage (BAL) from patients with lung TB and heavy smoker.Design and Methods: Experiments conducted in vitro with purified components revealed that TSG-6 had immunodetection in the Human Tracheal Aspirates (HTA) and BAL of heavy smoker and Lung Tuberculosis.Results: Immunoprecipitation revealed that TSG-6 accounts in airways hyperresponsiveness for significant proportion of BAL and HTA, but not in control (p < 0,01). TSG-6 relevant protease inhibitor in airway secretion. In primary cultures of differentiated human airway epithelial, which suggest that TSG-6 may be induced by TNF. Our results suggest that TSG-6 may play an important protective role in bronchial epithellium buy increasing the antiprotese screen on the airway lumen. The present study identifies a novel function of TSG-6 by a distinct mechanism system regulated, enhancement of anti TK activity, and provides a rational for this activity within the context of inflamed airways. These findings correlate with the observed increases in protein expressions in human HTA and BAL.Conclusions: TSG-6 are hyper-expressed in airway epithelial cells in cultures of smoker and lung TB. The interactions of TSG-6 with other molecules are also potentially important to the pathophysiologic aspects of inflammatory airways diseases that remain to be elucidated (Sains Medika, 3(1):31-40).
Faktor-Faktor yang Mempengaruhi Perilaku Minum Obat Tuberkulosis Novani, Deny; Suwandono, Agus; Trihadi, Djoko; Adi, M. Sakundarno; Suwondo, Ari
VISIKES: Jurnal Kesehatan Masyarakat Vol 16, No 1 (2017): VisiKes
Publisher : Dian Nuswantoro Semarang

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Abstract

The Multi Drug Resistance Tuberculosis (MDR TB) is tuberculosis resistance to minimum of two very potent TB drugs, Isoniazid and Rifampicin. Non-adherence to TB treatment may result in development of MDR TB. The study objective is to assess the risk factors of non-adherence to TB-treatment among MDR TB patients.This was the case control study, while case were non-adhere patients (n=57), and control were patients who are adhere to treatment (n=91). Total samples were 148 patients, with 10% of those who have risk Data was analyzed using bivariate analysis with Chi Square test, Odds Ratio (OR) and multivariate with logistic regression. There are two variables found as risk factors of non-adherence to TB treatment among MDRTB patients; treatment history (p=0,014; OR:2,648; 95%CI:1,215-5,771), duration of treatment (p=0,008; OR:2,960; 95% CI:1,320-6,638). Probability of non-adherence when there are thesetwo factors is 52,99%. Treatment history and duration of treatment were found as risk factors of non-adherence to TB treatment among MDR-TB patients in this study.Keywords: Risk factors, non-adherence to treatment, development of MDR TB