ENDANG MUTIAWATI, ENDANG
Neurology Department Faculty of Medicine Syiah Kuala University, Banda Aceh, Indonesia

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METHYLCOBALAMIN EFFECT ON MECHANICAL BEHAVIOR ALLODYNIA IN RATS SPRAGUE DAWLEY MUTIAWATI, ENDANG
Proceedings of The Annual International Conference, Syiah Kuala University - Life Sciences & Engineering Chapter Vol 4, No 2 (2014): Life Sciences
Publisher : Syiah Kuala University

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Neuropathic pain is an expression of the nerve damage that impaired its excitability, such as increased excitability in the nerve lesion and surrounding healthy nerves as well. It is estimated that the incidence of neuropathic pain ranges between 2-40% of all adult men. Some neuropathic pain can not be cured, such as in patients with diabetes mellitus, trigeminal neuralgia, cervical syndrome, carpal tunnel syndrome, lumbar stenosis, herniated nucleus pulposus and the carcinoma. The pathophysiology of neuropathic pain are complex and not fully understood. Methylcobalamin is a metabolite of vitamin B12 acts as a coenzyme in the formation of methionine from homocysteine. This reaction is useful in the formation of DNA, as well as maintenance of nerve function. Through the methylation reaction, methylcobalamin also plays a role in the formation of lecithin, a protein that plays an important role in the regeneration of peripheral nerves, including the formation of myelin. This study aimed to determine animal mechanical alodinia with or without the administration of methylcobalamin. Twenty male Sprague Dawley rats, aged 2 months, with an average weight of 150-250 g, obtained from the Laboratory LPPT Gadjah Mada University, Yogyakarta. The mice were randomly divided into 4 groups, each consisting of 5 mice. All the rats, their fifth lumbar nerve were ligated. Group I was the control mice (C) 0.9% NaCl given, group II (M1) were given a dose of 50 microg methylcobalamin, group III (M2) were given a dose of 100 microg methylcobalamin, while group IV (M3) were given a dose of 150 microg methylcobalamin 13 weeks provision. For 13 weeks, neuropathic pain behavior was assessed. Neuropathic pain behavior in experimental animals observed about onset, duration and filaments Von Frey numbers that cause mechanical alodinia. Result of the study showed methylcobalamin influence the mechanical alodinia. Based on the results obtained, it is concluded that there was a reduction in neuropathic pain in the methylcobalamin group compared with the control group.
HUBUNGAN KESIAPSIAGAAN DOKTER PUSAT KESEHATAN MASYARAKAT KOTA BANDA ACEH DENGAN MOTIVASI PENANGANAN PASIEN KECELAKAAN LALU LINTAS Syahrizal, Syahrizal; Mutiawati, Endang; Mudatsir, Mudatsir; Imran, Imran; Syahrul, Syahrul; Mulyadi, Mulyadi
Jurnal Kedokteran Syiah Kuala Vol 16, No 3 (2016): Volume 16 Nomor 3 Desember 2016
Publisher : Universitas Syiah Kuala

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Abstrak. Tujuan penelitian ini adalah untuk mengetahui hubungan kesiapsiagaan dokter pusat kesehatan masyarakat kota Banda Aceh dengan motivasi penanganan pasien kecelakaan lalu lintas. Penelitian ini merupakan penelitian analitik observasional dengan desain cross sectional. Populasinya adalah seluruh dokter umum yang ada di Pusat Kesehatan Masyarakat wilayah Kota Banda Aceh, dengan jumlah sampel 30 orang. Hasil penelitian ini menunjukkan, tingkat kesiapsiagaan dokter berdasarkan parameter pengetahuan berada pada kategori sangat siap dengan 56,7% responden, tingkat kesiapsiagaan dokter berdasarkan parameter sikap dengan 91,2% responden termasuk dalam kategori sangat siap, tingkat kesiapsiagaan dokter diukur berdasarkan parameter rencana tanggap darurat sebanyak 66,7% responden termasuk dalam kategori sangat siap, tingkat kesiapsiagaan dokter berdasarkan parameter sumber daya mendukung sebanyak 63,3% responden termasuk dalam  kategori sangat siap dan 93,3% responden memilki motivasi kuat dan hubungan kesiapsiagaan dengan motivasi  penanganan pasien kecelakaan  lalu lintas menunjukkan hubungan yang sedang dan berpola positif (p <0,001).(JKS 2016; 3: 153- 160)Kata kunci : Kesiapsiagaan,  motivasi, dokter,  parameter,  pasien Abstract. This aims of this study is to determine the relationship of physician preparedness in Banda Aceh public health centers (Puskesmas) with the motivation in handling traffic accident patients. This study is an analytic observational study with cross sectional design. The population is all of the general practitioners from the public health centers (Puskesmas) Banda Aceh, with the number of 30 people. The result of this study shows the level of physician’s preparedness based on knowledge is very prepared with 56,7% respondents, the level of physician’s preparedness based on attitude, there are 91,2% respondents included in the category of very prepared. The level of physician’s preparedness based on emergency plan is very prepared  with 66,7% respondents, the level of physician’s preparedness based on resource support is very prepared  with 63,3% respondents and 93,3% respondents have strong motivation and the relationship of physician preparedness with the motivation in handling traffic accident patients show showed a moderate relationship and positive pattern (p <0,001). (JKS 2016; 3: 153- 160)Keywords:Preparedness,motivation, doctor, parameter, patients 
Hubungan Derajat Stroke Terhadap Status Kognitif Pada Pasien Stroke Iskemik Di Poliklinik Saraf Rumah Sakit Umum Daerah dr. Zainoel Abidin Banda Aceh Nanda Putri, Mafruzah; Mutiawati, Endang; Mahdani, Wilda
Jurnal Ilmiah Mahasiswa Kedokteran Medisia Vol 2, No 1: Februari 2017
Publisher : Jurnal Ilmiah Mahasiswa Kedokteran Medisia

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Abstract

Stroke merupakan suatu penyakit serebrovaskular akibat penurunan atau terhentinya aliran darah ke otak. Penderita stroke biasanya akan mengalami kerusakan fungsi kognitif tergantung dengan derajat stroke yang dideritanya. Tujuan penelitian ini adalah untuk mengetahui hubungan derajat stroke terhadap status kognitif pada pasien stroke iskemik di Poliklinik Saraf RSUD dr. Zainoel Abidin Banda Aceh. Jenis penelitian ini adalah analitik observasional dengan desain cross sectional yang dilakukan pada bulan Oktober sampai Desember 2016.Penelitian ini menggunakan instrumen National Institutes of Health Stroke Scale (NIHSS) dan Mini Mental State Examination (MMSE).Data dianalisis dengan menggunakan uji korelasi Spearman. Sampel berjumlah 40 orang yang terdiri dari 24 orang (60,0%) pria dan 16 orang (40,0%) wanita dengan karakteristik responden usia diantara 56-65 tahun sebanyak 21 orang (52,5%), lulusan SMA sebanyak 20 orang (50,0%), memiliki riwayat hipertensi sebanyak 21 orang (52,5%) dan riwayat merokok sebanyak 22 orang (55,0%). Hasil penelitian didapatkan 22 orang (55,0%) mempunyai derajat stroke sedang dan 19 orang (47,5%) mengalami gangguan kognitif ringan. Terdapat hubungan yang kuat antara derajat stroke dengan status kognitif (p = 0,000, r = 0,603). Kesimpulannya terdapat hubungan yang kuat antara derajat stroke terhadap status kognitif pada pasien stroke iskemik di Poliklinik Saraf RSUD dr. Zainoel Abidin Banda Aceh.
HUBUNGAN INDEKS MASSA TUBUH (IMT) DENGANTINGKAT NYERI PADA PENDERITA LOW BACK PAIN (LBP)DI POLIKLINIK SARAF RSUD dr. ZAINOELABIDIN BANDA ACEH (RELATIONSHIP OF BODY MASS INDEX (BMI) WITH THE LEVEL PAIN WITH LOW BACK PAIN (LBP) IN NEUROLOGICAL CLINIC Dr. ZAINOEL ABIDIN HOSPITALS OF BANDA ACEH) Maulana, Ruli Syukran; Mutiawati, Endang; Azmunir, Azmunir
Jurnal Ilmiah Mahasiswa Kedokteran Biomedis Vol 1, No 4 (2016): Volume 1 Nomor 4 November 2016
Publisher : Jurnal Ilmiah Mahasiswa Kedokteran Biomedis

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Tujuan penelitian ini adalah untuk mengetahui hubungan antara Indeks Massa Tubuh dengan tingkat nyeri pada penderita low back pain. Penelitian ini menggunakan rancangan cross sectional dengan populasinya adalah seluruh pasien yang berobat ke poliklinik saraf RSUDZA Banda Aceh. Teknik pengambilan sampel dalam penelitian ini adalah non probability sampling dimana sampel telah memenuhi kriteria inklusi dan eksklusi.Dengan jumlah sampel sebanyak 47 orang sesuai dengan perhitungan rumus besar sampel. Data dikumpulkan menggunakan Comparative Pain Scale untuk menilai tingkat nyeri pada LBP dan melakukan pengukuran tinggi badan serta berat badan untuk mengetahui hasil dari IMT. Untuk mengetahui hubungan indeks massa tubuh dengan tingkat nyeri pada penderita LBP maka dilakukan Uji Spearman Rank Rho. Hasil penelitian menunjukkan bahwa ada hubungan yang bermakna antara indeks massa tubuh dengan tingkat nyeri pada penderita LBP di poloklinik saraf RSUDZA Banda Aceh dengan nilai p sebesar 0,00 (p<0,05).This study was conducted to determine the relationship between body mass index with the level of pain in low back pain. This study used a cross sectional design, where the population of this study was patients seek treatment at neurological clinic RSUDZA Banda Aceh. Sampling technique in this study is non probability sampling, in which the samples have fulfilled the inclusion and exclusion criteria. The total number of sample was 61 people, in accordance with the calculation of sample size. Data collected using the comparative pain scale to assess pain levels on LBP and performs measurements fo height and weight to find out results from IMT. To determine the relationship of body mass indeks with this level of pain on LBP, a spaeman rank rho test was performed.The result showed that there was significant association between body mass index with the level of pain in LBP at neurological clinic RSUDZA Banda Aceh, with a p-value of 0,00 (p<0,05).  
Pharmacologic Aspect of Neuropathic Pain Mutiawati, Endang; Indra, Imai; Syahrul, Syahrul; Mulyadi, Mulyadi
Proceedings of The Annual International Conference, Syiah Kuala University - Life Sciences & Engineering Chapter Vol 5, No 2 (2015): Life Sciences
Publisher : Syiah Kuala University

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Neuropathic pain is pain arising from nerve damage to the conductive pathways of pain (ranging from nociceptors to post central gyrus). Neuropathic pain can be caused by 1) Carcinomas, 2) Trap/compressive, 3) Congenital, 4) Immunomediated, 5) Infection, 6) Metabolic disorders, 7) nutritional deficiency, 8) Toxin, 9) Lesion, 10) Vasculitis, 11). Connective tissue disorders. To date, the pathophysiology of neuropathic pain can not be explained thoroughly, this problem leads to the treatment which has not given satisfactory results as expected. There are many types of drugs has been used for the treatment of neuropathic pain, and they are generally aimed to stop the flow of impulses in the nervous system which was activated as a result of ectopic generators in areas experiencing nerve injury. These drugs work in several locations such as: drugs that works on 'sodium channel  voltage  gate'  (i.e  Carbamazepine  group),  drugs  that  works  on  'calcium  channel'  (i.e Gabapentin and Pregabalin), and also drugs that works on ‘the synapses gap’ (i.e Tricyclic class). Besides drugs that inhibit pain impulses propagation, the treatment of neuropathic pain also include drugs that have the ability of nervous system regeneration such as methylcobalamin group. The rationale of the use of this kind of drugs is that this drug expected to regenerate the damage of the nervous system damage which is lead to decrease the ectopic generator activity, the end result is the reducement of neuropathic pain experienced by patients
Perbandingan Daya Ingat Anak Pada Sekolah Dasar Negeri Dan Sekolah Dasar Islam Terpadu Desrina, Desrina; Mutiawati, Endang; Yusuf, Rusli
Jurnal Ilmu Keperawatan Vol 6, No 1 (2018): Jurnal Ilmu Keperawatan (JIK)
Publisher : Jurnal Ilmu Keperawatan

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Kualitas  bangsa  di  masa  depan  ditentukan  oleh  kualitas  anak-anak  saat  ini.  Agar  memperoleh  pertumbuhan  dan perkembangan  anak  usia  sekolah  yang  optimal  maka  perlu  diperhatikan  asupan  nutrisi  baik  secara  kualitas  maupun kuantitas.  Dalam  masa  pertumbuhan  dan  perkembangan  tersebut  pemberian  nutrisi  atau  asupan  makanan  pada  anak tidak  selalu  dilakukan  dengan  sempurna.  Desain  penelitian  ini  adalah  kuantitatif  dengan  metode  komparatif.  Populasi dalam  penelitian  ini  adalah  anak  sekolah  dasar.  Teknik  pengambilan  sampel yang  digunakan quota  sampling berjumlah20  orang.  Hasil  uji  daya  ingat  anak  dari  ketiga  uji  daya  ingat  yang  dilakukan  pada  10  anak  SD  Negeri  tidak  ada  yangmemilki  skor  yang  tinggi,  sedangkan  untuk  SD  IT  dari  10  anak  yang  di  uji  daya  ingat  terdapat  anak  yang  memiliki  skortinggi,  pada  media  angka  terdapat  6  orang  (60%),  3  orang  (30%)  dan  1  orang  (10%)  pada  game  gadget.  Hasil  uji perbedaan diatas diketahui kolom T-Tes for Equality of Means pada variabel faktor individu, lingkungan dan daya ingat memiliki nilai  signifikan <  0,05 (p <  0,05),  faktor individu sebesar  0.007,  faktor lingkungan 0,026 dan daya ingat sebesar 0.015  dimana semua  nilai  variabel  <  0,05,  berarti  terdapat  perbedaan.  Sedangkan  untuk  faktor  objek  nilai  signifikan sebesar 0.717 (P>0.05) yang artinya tidak terdapat perbedaan antara faktor objek SD Negeri dengan SD IT.Kata Kunci : Perbandingan, daya ingat, sekolah negeri dan sekolah swasta.AbstractThe nation quality in the future is determined by the quality of the kids on this period. In order to achieve optimal growth of the kids at the school age, it is needed to  focus on the  nutrition on the kids which is probably cannot well given.  The design  of  this  study  is  quantitative  with  comparative  methods.  The  population  is  the  elementary  scho ol  students.  The sampling  technique  used  by  quota  sampling  was  20  people.  The  results  of  the  students's  memory  test  from  the  three memory tests were carried out on 10 public elementary school students, none of whom had a high score, while for the SD IT of 10 students who were tested for memory there were children who had a high score, in the media figures there were 6 students (60%), 3 students (30%) and 1 student (10%) in the gadget game. The results of the difference test above note that  the  T-Test  for  Equality  of  Means  column  on  the  variables  of  individual,  environmental  and  memory  factors  has  a significant value <0.05 (p <0.05), individual factors are 0.007, environmental factors are 0.026 and memory is 0.015 where all  variable  values are  <0.05,  meaning  there  are  differences.  Whereas  for  the  object  factor  significant  value  is  0.717  (P>0.05)  which  means  there  is  no  difference  between  the  object  factors  of  islamic  school  and  basic  school  of  elementary school.Keywords: Comparison,Memory, Public Schools and Private Schools
PENGUATAN PERAN POSYANDU DALAM MENINGKATKAN KETAHANAN MASYARAKAT TERHADAP BENCANA TSUNAMI DI WILAYAH PESISIR KOTA BANDA ACEH MENGGUNAKAN PENDEKATAN KNOWLEDGE MANAGEMENT Sartika, Eka; Munadi, Khairul; Mutiawati, Endang
Jurnal Ilmu Kebencanaan : Program Pascasarjana Unsyiah Vol 4, No 4: November 2017
Publisher : Jurnal Ilmu Kebencanaan : Program Pascasarjana Unsyiah

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The lack of disaster knowledge is one of the causes of the high casualties of women in the tsunami in Banda Aceh. Strengthening the posyandu's role in improving community resilience to disasters is essential. Research’s purpose is to identify posyandu role, strengthen posyandu role by analyzing the factors that become supporter and challenge faced by posyandu, and to initiate effective efforts in building disaster resilient community through Knowledge Management(KM) approach. The research uses quantitative and qualitative approach. Determination of sample by purposive involving 6 Posyandu located in coastal area of Banda Aceh City. Data were collected with questionnaires, in-depth interviews and focus group discussions. Analysis technique used is thematic analysis method. The results revealed that 77.8% of Posyandu managers have disaster knowledge at the medium level. Posyandu has many supporting factors to act as the agent of disaster knowledge dissemination. Strengthening the posyandu's role needs to be realized by continuous KM approach,  its strategy is to make the program regularly disseminate disaster knowledge, build Posyandu community network with non-formal learning facilities so that it can give input to policy and program in achieving development sustainable in  Banda Aceh.Key words :  Tsunami,  Posyandu, and  Knowledge Management
Pengaruh Edukasi Terhadap Tingkat Selfcare Perempuan Penderita Diabetes Mellitus Tipe 2 Di Puskesmas Aceh Besar Amalia, Rizka; Kamil, Hajjul; Mutiawati, Endang
Jurnal Ilmu Keperawatan Vol 6, No 1 (2018): Jurnal Ilmu Keperawatan (JIK)
Publisher : Jurnal Ilmu Keperawatan

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Abstrak Aktifitas selfcare diabetes merupakan hal penting dalam pengelolaan Diabetes Mellitus tipe 2, Namun dalam pelaksanaannya penderita diabetes seringkali tidak mengetahui tatacara perawatan mandiri diabetes yang mengakibatkan komplikasi dari penyakit semakin meningkat. Salah satu pilar penatalaksanaan diabetes adalah edukasi, dalam hal ini pemberian edukasi Aktifitas self-care diabetes diharapkan mampu memberikan informasi terkait pearawatan mandiri diabetes sehingga terbentuk perilaku perawatan mandiri diabetes yang sehat dan dinamis. Tujuan penelitian ini adalah adalah untuk mengidentifikasi pengaruh pemberian edukasi Aktifitas self-care diabetes terhadap tingkat selfcare penderita diabetes mellitus tipe 2 di puskesmas kecamatan Kuta Baro Aceh Besar. Penelitian pra experiment dengan one grup pre-test and post-test design melibatkan 52 responden perempuan anngota prolanis, Instrument penelitian yaitu Summary Diabetes Selfcare Actvitie (SDSCA). Data dianalisis menggunakan uji wilcoxon. Hasil penelitian menunjukkan terdapat terdapat perbedaan sebelum dan sesudah diberikan edukasi Aktifitas selfcare diabetes, Edukasi selfcare Aktifitas diet (P=0,00). Selfcare Aktifitas fisik (P=0,03) selfcare Aktifitas kontrol gula (P=0,00) self care Aktifitas pengobatan  (P=0,00) selfcare Aktifitas perawatan kaki (P=0,00) Artinya pemberian edukasi mempengaruhi aktifitas perawatan diri penderita diabetes sehingga Perlu dikembangkan edukasi diabetes yang terprogram terkait dengan self care diabetes.Kata Kunci : Selfcare Diabetes, Edukasi, DM tipe 2 AbstractDiabetes selfcare activity is the important things that can manage diabetes mellitus type 2. whereas in practice diabetics often do not know diabetes self-care procedures that cause complications of this disease be increasing. one of the pillars of diabetes management is education, in this case the education of diabetes selfcare activities is expected to be able to provide information related to independent diabetes selfcare so that healthy and dynamic diabetes self-care behavior is formed. the purpose of this study was to identify the effect of diabetes selfcare activity education on the level of self-care diabetes mellitus  type 2 at puskesmas kuta baro aceh besar.  the design of this research was praexperimental studies with pre experimental designs one group pretest and postest design involving 52 woman with diabetic tipe 2. The instrument used Summary Diabetes Selfcare Actvitie (SDSCA).  Data was analyzed using Wilcoxon test. Wilcoxon test resulth of this research between pre-post intervention of diabetes selfcare education was different (p-value < 0,05). that significant difference of pre-post intervention of diet P-value =0,00 (P-value < 0,05) , exercise P-value =0,03 (P-value < 0,05), medication P-value =0,00 (P-value < 0,05)  and blood-glucose control P-value =0,00 (P-value < 0,05) foot care P-value =0,00 (P-value < 0,05). This means that the provision of education influences the self-care activities of diabetics so that diabetes education is programmed to be developed related to diabetes self careKeywords : selfcare diabetes, education, diabetes meliitus tipe2
SCN1A exon 26 variants in epilepsy and migraine patients Lestari, Nova Dian; Mutiawati, Endang; Sadewa, Ahmad Hamim; Sjahrir, Hasan; Syahrul, .; Emril, Dessy Rakhmawati; Harapan, .
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 4 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Epilepsy and migraine are common neurological diseases in many populations. Mutation of the voltage gated natrium channel Nav1.1 (SCN1A) are important causes of different genetic epilepsies and can also cause familial hemiplegic migraine (FHM-III). This study aimed to identify SCN1A gene variation in patients with epilepsy and common migraine. Gene variation analysis of exon 26 of the SCN1A gene was carried out in 33 patients with epilepsy, 33 patients with migraine and 30 control individuals from Neurology Polyclinic at Dr. Zainoel Abidin General Hospital, Banda Aceh. The PCR and direct sequencing methods were performed in this study. SCN1A gene variations were identified in two epilepsy patients. These gene variations located at exon 26 were four silent mutations in patient E27 at position A4440T (Leu1480Leu), T4443C (Leu1481Leu), A5046G (Leu1682Leu) and C5121T (Asp1707Asp). One silent mutation in patient E30 at position G5505A (Glu1835Glu). None of these gene variations were identified in controls and patients with common migraine in this study. This study has identified 5 genetic variations of SCN1A in patients with epilepsy but not in common migraine. The mechanism and relationship between these variants and epilepsy need to be clarified.