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PENGARUH PEMBERIAN SIMETIDIN TERHADAP KADAR SGOT DAN SGPT TIKUS PUTIH (Rattus norvegicus) YANG DIBERI ANTI TUBERKULOSIS RIFAMPISIN DAN ISONIAZID Siswandari, Wahyu; Pribadi, Fajar Wahyu; Perdini, Eska
MANDALA of Health Vol 4, No 2 (2010): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Abstract

Tuberkulosis (TB) has long been known as an infection diseases, and has been reported to increased.The INH dan Rifampisin are two different drugs that are known tobe the most active drugs, therefore bothdrugs are being used as never ending drugs in curing the TB. Utilization of both INH and rifampisin in acombination to cure the TB patients, however could increase the possibility of hepar lession risk. Thisresearch was aimed to firstly, knowing whether cimetidine could prevent increase of SGOT and SGPT levelsof rats (Rattus norvegicus) given by both drugs INH and rifampisin, and secondly what was the minimumdose of cimetidine that able to prevent the increase of SGOT and SGPT levels. A Completely Random Design(CRD) was applied in this research, 24 male rats (Rattus norvegicus) of the wistar variety were divided into4 different groups. The first group, was only given the INH and rifampisin orally at the doses of 50 mg/Kgbody weight/day, the next groups groups II, III, and IV were also given those two drugs at the same dose, butthe cimetidine was also given at 112,5 , 225, and 450 mg/Kg body weight/day for the 28 days. Consequentlythe SGOT and SGPT levels were measured twice pre and post treatments. The data obtained were analysiedby the paired t test, a one way ANOVA, Post Hoc Tukey’s HSD, Kruskal-Wallis and Mann-Whitney test. Thisresearch result showed that the cimetidine that given following the INH and rifampisin could prevent theincrease of SGOT and SGPT levels. The highest dose of 450 mg/Kg body weight/day that given orally showedhighly significant different from other (p<0,00) in preventing the SGOT and SGPT of treated animals
PENGARUH PEMBERIAN SUSPENSI MENIRAN (Phyllanthus niruri L.) TERHADAP KERUSAKAN HEPAR TIKUS PUTIH YANG DIINDUKSI ANTITUBERKULOSIS RIFAMPISIN DAN ISONIAZID Sulistyoningrum, Evy; Pribadi, Fajar Wahyu
MANDALA of Health Vol 4, No 1 (2010): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Abstract

Tuberculosis treatment required at least two antituberculosis drugs (ATDs) and long term course.Isoniazid (INH) and Rifampicin are the two most active ATDs and were used in whole course of treatment.INH and Rifampicin combination increased risk of hepatotoxixity. Meniran (Phyllanthus niruri L.) containsphyllanthin, active subtance that is believed to have hepatoprotective activity. The aim of this study was toknow the effect of meniran suspension on AST/ALT blood levels and histopathological findings afterinduction of Rifampicin and INH. Twenty five male albino rats (Rattus norvegicus) wistar strain aged twomonths and weighed 150-200 grams were divided into five groups of five each. Positive control (A) wastreated with aquadest, negative control (B) was treated with Rifampicin and INH; one dose meniran (I) waspre-treated with 16,2 mg meniran before ATDs; two dose meniran (II) was pre-treated with 32,4 mg meniranbefore ATDs, three dose meniran (III) was pre-treated with 48,6 mg meniran before ATDs. The drugs wereadministered orally for 28 days. Blood samples for ALT/AST levels and histopathology sample were taken atthe end of study. One way ANOVA, post hoc and linear regression were used for data analysis. There wassignificant mean difference for ALT levels (p=0,000) but not for AST level (p> 0,05). Increasing dose ofmeniran decreased serum level of ALT (r=-0,539). Vacuolar degeneration, necrosis and portal triadleucocytes infiltration were most common in negative control groups, while these changes were reduced inmeniran-treated groups. We can conclude that meniran pretreatment reduces INH-rifampicin-inducedhepatotoxicity.
Pengaruh Pemberian Kafein Selama Kehamilan Terhadap Berat Lahir Dan Gambaran Histologis Uterus Dan Plasenta Tikus Putih (Rattus Norvegicus) Sulistyoningrum, Evy; Pribadi, Fajar Wahyu
Journal Of Holistic Nursing Science Vol 1 No 2 (2014)
Publisher : Universitas Muhammadiyah Magelang

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Abstract

  Kafein sering digunakan secara luas oleh masyarakat baik untuk konsumsi harian maupun pengobatan. Kafein dapat melewati sawar plasenta, masuk ke fetus dalam kadar yang seimbang dengan kadar maternal.  Tujuan dari penelitian ini adalah untuk mengetahui efek pemberian kafein selama kehamilan terhadap berat lahir fetus serta gambaran histologis uterus dan plasenta. Penelitian ini adalah eksperimen dengan menggunakan  tigapuluh ekor tikus putih galur Sprague-Dawley hamil, berumur sekitar 2 bulan dan berat 150-200 gram dibagi dalam enam kelompok, diobservasi sampai kelahiran kemudian dilakukan penimbangan berat lahir fetus dan pengamatan gambaran histologis uterus dan plasenta.Pada penelitian ini didapatkan hasil bahwa   pemberian  kafein selama kehamilan menurunkan rerata berat lahir fetus dan memberikan gambaran oedema, perdarahan dan peradangan pada jaringan uterus dan plasenta 
Peningkatan Penggunaan Antibiotik Secara Bijak Melalui Intervensi Alih Pengetahuan Untuk Merubah Persepsi Masyarakat di Kabupaten Banyumas Anjarwati, Dwi Utami; Pribadi, Fajar Wahyu; Peramiarti, Idsap
Jurnal Pengabdian Pada Masyarakat Vol 2 No 2 (2017)
Publisher : Universitas Mathla'ul Anwar Banten

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Abstract

IMPROVED USE OF ANTIBIOTIC BY USING TRANSFER OF KNOWLEDGE INTERVENTIONS TO CHANGE THE COMMUNITY PERCEPTION IN BANYUMAS DISTRICT. The use of antibiotics without indication by the medical community and the community became the trigger factor of increasing the incidence of antibiotic resistance in Indonesia. Meanwhile by 20150 antibiotic resistance is predictedto be the leading cause of death in the world. Community devotion was aimed at improving the understanding of society so that that is a change of perception about the use of antibiotic wisely. The target respondents of devotion consists of member of the family welfare empowerment group (PKK). A seriaes of activities undertaken were pre and post test to measure respondents' understanding of antibiotic use before and after intervention in the transfer of knowledge. The questionnaire used previously tested its validity by Pearson product moment test and its reliability by Alpha-Cronbach. The Sharpening of material obtained in knowledge transfer was done with role play and discussion. The result of T test analysis to score of quesionnaire before and after knowledge transfer showed significant p value (p = 0,049). The conclusion was that the transfer of knowledge can change the perception of PKK members about the wise use of antibiotics.