Soegeng Soegijanto
Head of Dengue Team Institute Tropical Disease, Airlangga University Surabaya

Published : 33 Documents
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Comparison of the efficacy and safety of hydroxyethyl starch 130/0.4 and Ringer's lactate in children with grade III dengue hemorrhagic fever Prasetyo, Risky Vitria; Azis, Abdul Latief; Soegijanto, Soegeng
Paediatrica Indonesiana Vol 49 No 2 (2009): March 2009
Publisher : Indonesian Pediatric Society

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Background Theoretically hydroxyethyl starch (HES) will givemore rapid recovery from shock, including in dengue shocksyndrome (DSS) and currently gained popularity for its lessdeleterious effects on renal function and blood coagulation.Objectives To compare the efficacy and safety ofHES 130/0.4 andRinger's lactate (RL) for shock recovery in children with DSS.Methods A randomized controlled study was performed on 39children admitted with DSS at Dr. Soetomo Hospital, Surabaya,between March and May 2007. Children were grouped intograde III (n=25) and grade IV (n=14) dengue hemorrhagicfever (DHF) according to the WHO criteria. Within eachgroup, subjects were randomly assigned to receive initial fluidresuscitation with either HES 130/0.4 (n=9 in the DHF grade IIIgroup, 10 in the DHF grade IV) or RL (n= 16 in the DHF gradeIII group, 4 in the DHF grade IV). Clinical and laboratory datawere collected to determine improvements in shock recovery andadverse reactions.Results In both the grades III and IV DHF, HES 130/0.4significantly decreased hemoglobin and hematocrit levels. Clinicalimprovements in pulse pressure and pulse rate were seen aftertreatment with HES 130/0.4 although these were statisticallyinsignificant if compared to the RL group. No differences in fluidrequirement and recurrent shock episodes were noted betweenthe RL and HES groups. No adverse reactions were found duringthe study.Conclusion HES 130/0.4 administration is effective and safe inchildren with DSS.
The Role Activity of Complement, TNFα & IL12 in Pathogenesis Dengue Virus Soegijanto, Soegeng; Sary, Dian Dwi; Setiawan, Budi; Yamanaka, Atsushi
Indonesian Journal of Tropical and Infectious Disease Vol 1, No 1 (2010)
Publisher : Institute of Topical Disease

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Dengue Virus infection is always found in some part of the world especially South East Asia including Indonesia. The pathogenesis of Dengue Virus infection is still controversial. The aim of this study is to analyze the role complement activity, TNFα & IL12 in Dengue Virus infection especially in pathogenesis of Dengue Virus infection. Cross sectional study had been done since February 2009 in Dr. Soetomo Hospital Surabaya. Blood Sera of Dengue Virus infection were collected from Dengue Fever, and Dengue Hemorrhagic Fever patient who had been care in Paediatric. Dengue patients and time schedule for taking blood sample for examination CH50, TNFα & IL12 as follow: on the first day on admission, the second day, the third day. Study groups of patients as follow: Dengue Fever, 36; Dengue Hemorrhagic Fever grade I, 37; Dengue Hemorrhagic Fever grade II, 10; Dengue Hemorrhagic Fever grade III, 18; Dengue Hemorrhagic Fever grade IV, 6. In this study found that the higher activity complement which lower level CH50 was more identified on Dengue Shock Syndrome and Dengue Hemorrhagic Fever grade III than Dengue Fever cases. A concept of our study was focusing on manifestation of vascular leakage, measurement of complement activity CH50, TNFα & IL12 and clinical manifestation Dengue Hemorrhagic Fever. The examination of TNFα & IL12 in our study supported the role the activity complement. The conclusion are measurement CH50, TNFα & IL12 can be used as a predictive factor of the degree of Dengue Virus infection
UPDATE MANAGEMENT OF DENGUE COMPLICATION IN PEDIATRIC Soegijanto, Soegeng
Indonesian Journal of Tropical and Infectious Disease Vol 2, No 1 (2011)
Publisher : Institute of Topical Disease

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Dengue virus infection is one of the important health problems in Indonesia, although the mortality rate has been decreased but many dengue shock syndrome cases is very difficult to be solving handled. It might be due to nature course of dengue virus infection is very difficult to predict of the earlier time of severity occur. THE AIM To get idea to make update management of dengue complication in pediatric. MATERIAL AND METHOD Data were compiled from Dr. Soetomo Hospital Surabaya in 2009. The diagnosis of all cases was based on criteria WHO 1997 and PCR examination in Institute Tropical Disease for identified serotype of dengue virus infection. The unusual cases of dengue virus infection were treated following the new WHO protocol in 2009. RESULT There were only 3 cases with serotype DEN 1, consisted 2 cases had age 1–4 years and 1 had age 5–14 years. 2 cases showed a severe clinical performance as dengue shock syndrome and 1 case showed as unusual case of dengue virus infection. Three report cases of: a. Dengue hemorrhagic fever grade III which liver involvement and had bilateral pleural effusion; b. Dengue hemorrhagic grade III with liver involvement and encephalopathy; c. Dengue hemorrhagic grade III with liver involvement acute kidney injury, myocardial involvement and encephalopathy. All the patients were treated according to new edition WHO protocol and all of the involving organ recovered along with the improvement of the disease. CONCLUSION Update management of dengue complication pediatric should be learned carefully used for helping unusual cases of dengue virus infection.
THE MONTHLY CHANGING OF THE LOWEST POPULATION DENGUE VIRUS INFECTION IN PATIENT AT SOERYA HOSPITAL SIDOARJO IN 00 Soegijanto, Soegeng
Indonesian Journal of Tropical and Infectious Disease Vol 2, No 1 (2011)
Publisher : Institute of Topical Disease

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Background: Dengue virus infection is one of the important health problems in Indonesia, although the mortality rate has been decreased but many dengue shock syndrome cases is very difficult to be solving handled. To solve this problem, some factor that influence the prevalence of dengue virus infection should be studied. The Aim of Study: To detect some factor that maintain the higher case of dengue virus infection in patient at the Soerya Hospital Sepanjang, Sidoarjo. Material & Method: Study had been done at Soerya Hospital Sepanjang, Sidoarjo since January 1, 2007 until December 31, 2010. All cases suspected dengue virus infection in patient at soerya hospital were diagnosed based on WHO criteria in 1997 and PCR examination in ITD laboratory. The Result: In 2007, 2008, 2009, the monthly observation showed that decreasing cases of dengue virus infection in patient at Soerya Hospital had been found on September, but in 2010 this event had been found on November. Why this event to be change? It is suggested might be due to global warming in the world and the climate going to influence the environment sanitation. Interaction between agent host and environment becoming increase it might be due to the changing of climate can influence the growing population Aedes Aegyptie and Aedes Albopictus promoting to increase vector for transmit dengue virus infection. It is prominent in sub urban area, with have many peoples don’t aware with the bad environment sanitation. And many peoples showed very dynamic for living until the idea good environment do not be thought. By this condition the monthly population dengue virus infection in patient at hospital are going to maintain higher more than six months than usually. On the year 2007, 2008, 2009 the lowest cases found on September. In 2010, the lowest cases had been found on November. The Conclusion: Global warming, increasing sub urban area which have many peoples don’t aware with the bad environment sanitation and have highly dynamic peoples for getting some money for their life, could influence the higher cases dengue virus infection in patient at hospital more than 6 months.
UPDATE MANAGEMENT DENGUE SHOCK SYNDROME IN PEDIATRIC CASES Soegijanto, Soegeng; Chilvia, Eva
Indonesian Journal of Tropical and Infectious Disease Vol 4, No 4 (2013)
Publisher : Institute of Topical Disease

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Background: Since 1968 Dengue Virus Infection has been found in Indonesia, especially at Surabaya and Jakarta city. Firstly management of dengue virus infection very difficult to improve, therefore the higher mortality nearly 41,4% had been found but on the following years in five decades the mortality rates was becoming to decrease until 1,27% on 2011. Aim: To find the new management of Dengue Shock Syndrome to reach the lower fatality rate below 1%. Method: Until now to manage Dengue Shock Syndrome is very difficult, some cases can be improved but the other lost due to the late coming in the hospital and not involved in criteria diagnosis base on WHO 1997. To solve this problem WHO 2009 had made new criteria diagnosis Dengue Virus Infection focusing on early detection of severe Dengue Virus Infection especially Dengue Shock Syndrome. Result: On 2011 WHO had made an integrated criteria diagnosis base on WHO 2009 and WHO 1997. These criteria was focusing in Update management of Dengue Shock Syndrome in Pediatric Cases. Based on this action, this paper will improve clinical management to reach the lower mortality of Dengue Shock Syndrome in Community until CFR < 1%. Conclusion: By using integrated criteria of WHO 2009 and 1997, update management of Dengue Shock Syndrome in Pediatric cases, can improve clinical management to reach the lower mortality in community until CFR < 1%.
THE CHANGING CLINICAL PERFORMANCE OF DENGUE VIRUS INFECTION IN THE YEAR 2009 Soegijanto, Soegeng; Susilowati, Helen; Mulyanto, Kris Cahyo; Hendrianto, Eryk; Yamanaka, Atushi
Indonesian Journal of Tropical and Infectious Disease Vol 3, No 1 (2012)
Publisher : Institute of Topical Disease

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Background: Dengue (DEN) virus, the most important arthropod-borne human pathogen, represents a serious public health threat. DEN virus is transmitted to humans by the bite of the domestic mosquito, Aedes aegypti, and circulates in nature as four distinct serological types DEN-1 to 4). The aim of Study: To identify Dengue Virus Serotype I which showed mild clinical performance in fiveyears before and afterward showed severe clinical performance. Material and Method: Prospective and analytic observational study had been done in Dr. Soetomo Hospital and the ethical clearance was conduct on January 01, 2009. The population of this research is all cases of dengue virus infection. Diagnosis were done based on WHO 1997. All of these cases were examined for IgM & IgG anti Dengue Virus and then were followed by PCR examination to identify Dengue Virus serotype. Result and Discussion: DEN 2 was predominant virus serotype with produced a spectrum clinical illness from asymptomatic, mild illness to classic dengue fever (DF) to the most severe form of illness (DHF). But DEN 1 usually showed mild illness. Helen at al (2009–2010) epidemiologic study of Dengue Virus Infection in Health Centre Surabaya and Mother and Child Health Soerya Sidoarjo found many cases of Dengue Hemorrhagic Feverwere caused by DEN 1 Genotype IV. Amor (2009) study in Dr. Soetomo Hospital found DEN 1 showed severe clinical performance of primary Dengue Virus Infection as Dengue Shock Syndrome two cases and one unusual case.Conclusion: The epidemiologic study of Dengue Virus Infection in Surabaya and Sidoarjo; in the year 2009 found changing predominant Dengue Virus Serotype from Dengue Virus II to Dengue Virus 1 Genotype IV which showed a severe clinical performance coincident with primary infection.
SERO-EPIDEMIOLOGY OF DENGUE VIRUS INFECTION IN CITIES OF INDONESIA Soegijanto, Soegeng; Mulyanto, Kris Cahyo; Churotin, Siti; Kotaki, Tomohiro; Kamioka, Masa Nori; Konichi, Eiji; Yamanaka, Atsusi; Wikanesthi, Dyah
Indonesian Journal of Tropical and Infectious Disease Vol 4, No 4 (2013)
Publisher : Institute of Topical Disease

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Background: Dengue Virus Infektion is major public health problem in Indonesia. Aedesaegypti is widespread in both urban and rural areas, where multiple virus Serotype are circulating. On 2013 outbreak of dengue virus infection occur in East Java. Therefore study seroepidemiology in Bangkalan and Lombok had been done. Aim: to find a mutated strain of Dengue Virus in 4 cities of Indonesia. Method: On 2011 and 2012 seroepidemiology study had been done in Dr. Soetomo Surabaya and Soerya Sidoarjo Hospital; and on  2013 study had been done in Surabaya, Bangkalan and Lombok Hospital . Diagnosis of Dengue Virus Infection was based on Criteri WHO - 2009. Virus isolation in Surabaya, Sidoarjo, Bangkalan and Lombok had been done. Result: a total of 349 isolate were obtained from dengue patients sera collected in Surabaya and Sidoarjo, 2011–2012 showed that Den V1 (182), Den V2 (20) Den V4 (1) were found in Surabaya on 2011 and Den V 1 (79) , Den V 2 (7) were found in Surabaya on 2012; Den V1 (40), Den V 2 (3) were found in Sidoarjo on 2011 and Den V 1 (17) were found in Sidoarjo on 2012; Virus isolation in Surabaya on 2013, January: 237 serum sample were collected, found Den V 1 (8), Den V 3 (2) and Den V 4 (5). And PCR stereotyping of isolated viruses in Madura found Den V 1 (1) and Den V 4 (23). In Lombok found Den V 4 (4).It is possible to shift predominant strain in Surabaya , Genotype or Serotype shift might increase the number of dengue patients. Conclusion: there were shift predominant strain in Surabaya especially Den V 1. Therefore to continuous surveillance of circulating viruses is required to predict the risk of DHF and DF.
UPDATE MANAGEMENT CONCURRENT INFECTION BETWEEN DENGUE VIRAL AND SALMONELLA Wikanesthi, Dyah; Sari, Desiana W; Chilvia, Eva; Soedirham, Oedojo; Kurniasari, Lely; Soegijanto, Soegeng
Indonesian Journal of Tropical and Infectious Disease Vol 5, No 3 (2014)
Publisher : Institute of Topical Disease

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Since Januari 2013, Soerya Hospital has found many cases with positive result of IgM Salmonella along with NS1 or IgM & IgG Dengue. The clinical manifestations mostly are high fever, headache, vomiting, malaise and plasma leakage. Some of them with convulsion and unconsciousness. Therefore in order to get well of care management, this clinical phenomena should be studied carefully. The aim of this research is to get update management concurent Dengue Viral and Salmonella infection. Observational study had been done, since Januari 2013 until Juli 2013. Purposive sampling in 30 case of concurent Dengue Viral and Salmonella infection compared with 30 case of Dengue Viral infection alone. Diagnosis has published based on WHO 2011 criteria. By using anti vomiting drug, anti pyretic, anti convulsion and antibiotic for Salmonella infection and rehidration using Ringer Acetate, combining Ringer Asetat andDextrose 5% or combining Ringer Asetat Saline 0,225% or solution of Dextrose 5% and Saline 0,45 during 4–5 days hospitalization. The result show that all cases were recovered and got well. There is no significant different between concurent Dengue Viral and Salmonella infection compared with Dengue Viral infection alone. Some cases showed that length time to stay in hospital become1–2 days longer. It was due to delayed getting antibiotic for Salmonella infection. All cases had got first drugs accurately in a clinical manifestation that has been daily showed. It was as a problem solving for saving all the cases.
Molecular Surveillance of Dengue Virus Serotype Using Polymerase Chain Reaction in Surabaya 2013 Sucipto, Teguh Hari; Labiqah, Amaliah; Churrotin, Siti; Ahwanah, Nur; Mulyatno, Kris Cahyo; Soegijanto, Soegeng; Kotaki, Tomohiro; Kameoka, Masanori; Konishi, Eiji
Indonesian Journal of Tropical and Infectious Disease Vol 5, No 1 (2014)
Publisher : Institute of Topical Disease

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Dengue is one of the infectious diseases which is endemic in the tropical and sub-tropical country. The disease found in Indonesia Surabaya, 1968. The symptoms of Dengue virus infections are two kinds, first DF (Dengue Fever), second DHF (Dengue Hemorrhagic Fever). This infectious disease transmitted by Aedes aegypti mosquito. Mosquitoes breed in clean water areas. More than 100,000 cases of DF/DHF ccurred in Indonesia every year. The purpose of this study were to provide information and the spread of dengue virus types in Surabaya from January 2013 to September 2013. The nalysis technique used to determine the type of dengue virus nfectionwas used PCR (Polymerase Chain Reaction). The results obtained 69% DENV-1, 27% DENV-2 isolates, 4% isolates DENV-3, and 0% DENV-4 isolates.
AWARENESS OF USING RINGER LACTAT SOLUTION IN DENGUE VIRUS INFECTION CASES COULD INDUCE SEVERITY Soegijanto, Soegeng; Sari, Desiana W.; Yamanaka, Atsushi; Kotaki, Tomohiro; Kameoka, Masanori; Konishi, Eiji
Indonesian Journal of Tropical and Infectious Disease Vol 4, No 4 (2013)
Publisher : Institute of Topical Disease

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Background: In 2012, serotype of Dengue Virus had changed from Den-2 and Den-3 to Den-1. In 5–10 years ago, serotype of Den-1 case showed a mild clinical manifestation; but now as a primary case it can also show severe clinical manifestation. One of indicator is an increasing liver enzyme, AST and ALT, with level more than 100–200 U/L. Aim: To getting a better solutions for this problem. Method: Obsevasional Study had been done in medical faculty of Airlangga University (Dr. Soetomo and Soerya hospital) Surabaya on Mei–August 2012. There were 10 cases of dengue virus infection were studied, 5 cases got Ringer Acetate solution (Group A) and 5 cases got Ringer Lactate solution (Group B). The diagnosis was based on criteria WHO 2009. Result: Five cases of Dengue Virus Infection had showed a liver damage soon after using Ringer Lactate solution; AST and ALT were increasing more than 100–200 U/L; but the other 5 cases showed better condition. It might be due to use Ringer Acetate that did not have effect for inducing liver damage. By managing carefully, all of the cases had shown full recovery and healthy condition when being discharged. Conclusion: Using Ringer Acetate as fluid therapy in Dengue Virus Infection is better to prevent liver damage than using Ringer Lactate.