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Uji Stabilitas Kimia Natrium Askorbil Fosfat Dalam Mikroemulsi Dan Analisisnya Dengan HPLC Deviarny, Chris; Lucida, Henny; Safni, Safni
Jurnal Farmasi Andalas Vol 1, No 1 (2013)
Publisher : Jurnal Farmasi Andalas

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It has been tested the influence of pH, the influence of microemulsion types and the influence of storage temperature on the stability of natrii ascorbyl phosphate (which is often known as Sodium Ascorbyl Phosphate/SAP) and analysis using HPLC method. Kinetics test carried out by dissolving the SAP in a buffer solution with different pH, namely: 4.5: 5.5: 6.5 and 7.5 at a temperature of 300C and 400C. SAP decomposes according to first-order kinetics (y = -0.0027 x - 3.5224 and r = 0.9546, price the value of k = 6.2181 x 10-3 per minute) with a slow rate of decomposition at pH 6.5. Furthermore, SAP isformulated in the preparation of microemulsion type of M/A and A/M with anoptimum pH conditions for SAP, then tested the stability of SAP with SAP store at  temperatures 300C and 400C for one week. The remaining levels of SAP werecalculated and analyzed by one-way T-tested method. Showed that the type of chemical stability of microemulsions affect SAP which is morestable in the microemulsion type of M/A.   
Pemanfaatan Pati Beras Ketan Pragelatinasi sebagai Matriks Tablet Lepas Lambat Natrium Diklofenak Lukman, Anita; Lucida, Henny; Ben, Elfi Sahlan
Jurnal Sains dan Teknologi Farmasi Vol 17 No 1 (2012)
Publisher : Fakultas Farmasi Universitas Andalas

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A study on the use of pregelatinized glutinous rice starch in combination with sodium carboxy methyl cellulose as sustained release matrix and sodium diclofenac as a model has been conducted. Two formulas were prepared with these ratio of pregelatized glutinous rice starch to Na CMC of (42,70% : 14,25 %) (F1) and (28,5% : 28,5 %) (F2) respectively. Evaluation of pharmaceutical properties of the tablets showed that all formulas fulfilled the requirement in term of weight uniformity, content uniformity, friability, hardness and disintegration time. Dissolution profile showed that F1 showed down the release of drug at 86% in 12 hours, while F2 80,16 % in 12 hours.
Pengembangan Kulit Buah Kering Asam Kandis sebagai Herbal Medicine: Optimasi Formulasi Tablet Effervesen dan Uji Efeknya Terhadap Kenaikan Berat Badan dan Pola Makan Tikus Lucida, Henny; Ben, Elfi Sahlan; Delita, Elfi
Jurnal Sains dan Teknologi Farmasi Vol 17 No 2 (2012)
Publisher : Fakultas Farmasi Universitas Andalas

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This paper reports an optimization technique of effervescent tablet formulation from the ethanolic extract of “asam kandis” dried rinds (Garcinia cowa Roxb) and an assay of its reconstituted solution effect on rat’s body weight and feeding behavior. Formulation optimization was done by factorial design of 2 factors (extract concentration; composition of tablet disintegrant) and 3 levels. Nine formulas (FI – FIX) were prepared and subjected to evaluations including granule’s physicochemical and tablet’s pharmaceutical properties. The best formula was then chosen and given orally to 4 groups of rats: that was given standard food, high fat diet, high fat diet with reconstituted tablet 250 mg and high fat diet with reconstituted tablet 500 mg respectively. All groups were given 10 g of standard food every day for 10 days followed by high fat diet for the next 22 days. Two treatment groups were given reconstituted tablet at day 11th. The amount of food consumed by each group was weighed and rat’s body weight was measured. The optimization technique showed that both factors influenced the physicochemical properties of granules and the pharmaceutical properties of tablets significantly (p < 0.05). FV (extract concentration 500 mg, disintegrant: sodium bicarbonat 500 mg + citric acid 200 mg + tartaric acid 200mg) was chosen as the best.  Results showed that administration of reconstituted tablet FV to rats increased the bodyweight of the treated groups for the first week which then decreased during the next 3 week observation, while the body weight of control group kept increasing. Reconstituted tablet at dose 500 mg significantly influenced rat’s bodyweight and the feeding behavior (p<0.05). The group given reconstituted tablet 500 mg had the lightest body weight and consumed the least food during 3 weeks observation.
Analisis Aspek Farmakokinetika Klinik Pasien Gagal Ginjal pada Irna Penyakit dalam RSUP Dr. M. Djamil Padang Lucida, Henny; Trisnawati, Riah; Suardi, Muslim
Jurnal Sains dan Teknologi Farmasi Vol 16 No 2 (2011)
Publisher : Fakultas Farmasi Universitas Andalas

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A study on the evaluation of clinical pharmacokinetic aspect to in-patient with renal failure at internal Ward Dr. M. Djamil hospital Padang has been conducted. The aspect studied was dosage individualization bades on patient’s patophysiological condition. The study aimed at comparing the dosage regimen given to the renal failure patient with that calculated using pharmacokinetic equations. This study was observasionaly prospective by using cross-sectional method. In the period of June – September 2010, 48 renal failure patients includes in inclusion criterion. Results showed that medications which mainly renal excreted or potentially nephrotoxic given to patients are ciprofloxacin, digoxin, ranitidin, metformin, captopril, furosemide and hydrochlortiazide. Patients treated with those medications were evaluated in terms of dosage regimens and clinical response. There were 4 cases of higher dose than recommended included 1 of 8 cases of captopril use, 2 of 9 cases of ciprofloxacin use and 1 of case of metformin use. It uses also found that hydrochlortiazide which should be avoided to patients with Clcr < 30 ml/min (4 cases)
Uji Dissolusi Terbanding Sediaan Padat Gemfibrozil Generik dan Merk Dagang yang Beredar di Indonesia Lucida, Henny; Dachriyanus, Dachriyanus; Elyunaida, Elyunaida
Jurnal Sains dan Teknologi Farmasi Vol 19 No Supl1 (2017): Vol 19 Supplement 1, December 2017
Publisher : Fakultas Farmasi Universitas Andalas

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Telah dilakukan uji dissolusi terbanding 9 sediaan padat yang mengandung gemfibrozil sesuai persyaratan Farmakope Indonesia edisi 4. Produk yang diuji terdiri dari 3 sediaan generic dan 6 sediaan merek dagang yang beredar di Indonesia. Penelitian ini bertujuan untuk memperoleh data biofarmasetik in-vitro yang menggambarkan mutu gemfibrozil generic dan merek dagang di pasaran. Uji dissolusi dilakukan menggunakan metoda dayung dalam medium 900 mL dapar pospat 0,2 M pH 7,5 ± 0,05 dan analisis kuantitatif menggunakan spektrofotometer UV pada panjang gelombang serapan maksimum 278 nm. Produk GF 7, salah satu obat generic, dipilih sebagai innovator. Profil dissolusi antara innovator dengan produk terbanding dianalisa menggunakan factor similaritas (f2). Hasil menunjukkan bahwa nilai f2 semua produk terbanding < 50%; dimana profil dissolusi semua produk terbanding berbeda nyata dengan innovator (P<0,05). Perbedaan ini didukung oleh data difraksi sinar X yang menunjukkan semua produk memiliki indeks kristalinitas yang berbeda.
Formulasi Masker Peel-Off Dari Ekstrak Etanol Kulit Buah Asam Kandis (Garcinia cowa, Roxb) dan Uji Aktivitas Antioksidan nya Lucida, Henny; Fitri, Ema; Hosiana, Vinny
Jurnal Sains dan Teknologi Farmasi Vol 19 No 1 (2017)
Publisher : Fakultas Farmasi Universitas Andalas

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Telah diformulasi masker peel off dari ekstrak etanol kulit buah asam kandis (Garcinia cowa, roxb) sebagai kosmetik dalam tiga formula dengan konsentrasi 1%; 1,5% dan 2% dengan menggunakan Poli Vinil Alkohol (PVA) sebagai bahan pembentuk lapisan film, Poli Vinil Pirolidon (PVP) sebagai pengental, propilenglikol sebagai humektan, nipagin dan nipasol sebagai pengawet dan etanol sebagai pelarut. Evaluasi masker meliputi pemerian, homogenitas, pemeriksaan pH, uji daya menyebar, uji iritasi kulit, uji elastisitas, uji waktu mengering, uji stabilitas fisik terhadap pendinginan dan uji aktivitas antioksidan menggunakan metoda DPPH (1,1-difenil-2-pikrihildrazil). Dari hasil evaluasi, ketiga formula relatif stabil secara fisik selama 6 minggu penyimpanan, dan masker yang paling baik adalah formula II dengan konsentrasi ekstrak etanol kulit buah asam kandis 1,5%.
Karakterisasi dan Studi Aktivitas Antioksidan dari Ekstrak Etanol Secang (Caesalpinia sappan L.) Febriyenti, Febriyenti; Suharti, Netty; Lucida, Henny; Husni, Elidahanum; Sedona, Olivia
JSFK (Jurnal Sains Farmasi & Klinis) Vol 5, No 1 (2018): J Sains Farm Klin 5(1), April 2018
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.5.1.23-27.2018

Abstract

Secang (Caesalpinia sappan L.) secara tradisional digunakan untuk mengobati berbagai penyakit. Secang mengandung senyawa fenolik seperti asam gallat, brazilin dan brazilein. Tujuan penelitian ini adalah untuk mengkarakterisasi simplisia dan ekstrak etanol secang, mengevaluasi kandungan fenolik total dan menentukan aktivitas antioksidan ekstrak etanol secang. Karakterisasi simplisia secang diperoleh susut pengeringan sebesar 10,349 %, kadar sari larut air sebesar 3,293 %, kadar sari larut etanol sebesar 6,026 %, kadar abu total sebesar 0,6509 % dan kadar abu tidak larut asam simplisia adalah sebesar 0,480 %. Karakterisasi ekstrak etanol secang diperoleh kadar abu total sebesar 1,26 %, kadar abu tidak larut asam ekstrak sebesar 0,059 %, kadar air ekstrak didapatkan hasil 8,63 %. Kadar fenolik total ekstrak etanol secang adalah 71,144 g/100g. Semakin tinggi kadar fenolik total, maka semakin tinggi pula aktivitas antioksidannya. Aktivitas antioksidan ekstrak etanol secang ditentukan dengan metode FRAP (Ferric Reducing Antioxidant Power) dan hasilnya adalah 13,99 mmol Fe(II)/100g.
OPTIMASI KOMBINASI PENGHANCUR DAN PENGIKAT DALAM FORMULASI TABLET EKSTRAK ETANOL DAUN Eugenia cumini Merr. Lucida, Henny; Saputra, Harry; Arifin, Helmi
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 4, No 3 (2009)
Publisher : Indonesian Research Gateway

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Preclinical studies of the aethanolic extract of the leaves of Eugenia cumini Merr (Jamblang, jambu kaliang) showed that it decreased the blood glucose level of mice at the doses of 50, 100 dan 200 mg/kg BW respectively. The extract was not toxic with the LD50 >15g/kg BB. The acute and sub-acute toxicity studies indicated that the extract was safe for a long use in mice. These results supported the potencial of this extract to be formulated as drug. This study reported the optimization technique used in the formulation of tablet of the aethanolic extract of Eugenia cumini Merr leaves to obtain best formulation with combination of dissintegrant and binder with respect to tablet dissintegration time. Four formulations containing  250 mg of extract were prepared by wet granulation. Results showed that granules of each formulas fulfilled the requirements of granules physical properties except granules a and b for its moisture content. The tablets also fulfilled the Indonesia Phamacopeia requirements except formula b for dissintegration time. Formulation of tablet based on optimization (amprotab 11% and PVP 2%) resulted in tablets with dissintegration time of 499 seconds (contour plot showed 443 seconds). ABSTRAK Uji preklinis menunjukkan bahwa ekstrak etanol daun Eugenia cumini Merr (Jamblang, jambu kaliang) dengan dosis 50, 100 dan 200 mg/kg BB dapat menurunkan kadar glukosa darah hewan percobaan. Ekstrak ini tergolong tidak toksik dengan LD50 >15g/kg BB. Uji toksisitas akut  dan toksisitas sub akut menunjukkan bahwa ekstraks ini aman digunakan dalam jangka waktu lama. Dengan demikian senyawa ini berpotensi untuk dikembangkan menjadi fitofarmaka. Makalah ini melaporkan hasil penelitian tentang optimasi kombinasi penghancur dan pengikat dalam formulasi tablet antidiabetes dari ekstrak etanol daun Eugenia cumini Merr. Dibuat empat formula tablet yang mengandung ekstrak sebesar 250 mg secara granulasi basah, dengan amprotab sebagai penghancur dan polivinilpirolidon (PVP) sebagai pengikat. Respon yang diukur adalah sifat fisik granul, sifat fisik tablet dan waktu hancur tablet. Hasil penelitian menunjukkan bahwa granul yang dihasilkan memenuhi persyaratan uji sifat fisik granul kecuali formula a dan b untuk uji kandungan lembab. Tablet yang dihasilkan memenuhi persyaratan tablet menurut Farmakope Indonesia kecuali formula b untuk waktu hancur tablet. Variasi konsentrasi amprotab berpengaruh dominan terhadap waktu hancur tablet dibandingkan dengan variasi konsentrasi PVP. Formulasi tablet ekstrak etanol daun Eugenia cumini Merr berdasarkan hasil optimasi (amprotab 11% dan polivinilpirolidon 2%) memberikan tablet dengan waktu hancur 499 detik.
FORMULATION OF ANTI-PLAQUE TOOTHPASTE FROM STANDARDIZED GAMBIR EXTRACT AND ITS ANTIMICROBIAL ACTIVITY Lucida, Henny; Rustini, .; Saufitri, Dian; Dachriyanus, .
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 5, No 2 (2010)
Publisher : Indonesian Research Gateway

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Telah dilakukan formulasi pasta gigi ekstrak gambir terstandarisasi serta uji daya antimikrobanya terhadap pertumbuhan bakteri penyebab plak Streptococcus mutans. Uji pendahuluan menunjukkan bahwa ekstrak gambir terstandarisasi pada kadar 7% memiliki diameter hambat optimal terhadap pertumbuhan mikroba uji. Berdasarkan ini dibuat 3 formula pasta gigi dengan kadar ekstrak gambir terstandarisasi sebesar 7% dengan kosentrasi kalsium karbonat (abrasif) yang bervariasi, berturut-turut 37, 42 dan 47%. Semua formula diuji sifat-sifat farmasetik dan aktivitas antimikrobanya, sebagai pembanding digunakan pasta gigi “F”. Hasil evaluasi sifat farmasetika sediaan menunjukkan semua formula memenuhi persyaratan pastagigi yang baik.  Formula 3 (F3) memberikan diameter hambat paling baik (19,25 + 0,50 mm), sedangkan pembanding “F” memberikan diameter hambat (20,0 + 0,00 mm).  Terdapat perbedaan bermakna diameter hambat antar perlakuan (basis versus pasta gigi ekstrak gambir) pada taraf kepercayaan  0,05.   ABSTRACT A toothpaste containing standardized gambir extract had been formulated and an antimicrobial assay of the toothpaste against Streptococcus mutans had been done. Preliminary study showed that the concentration of gambir extract of 7 % obtained an optimal range of inhibition of S. mutans growth. Three formulas were then prepared, which contained 7 % extract and various concentrations of calcium carbonate (37, 42 and 47 % respectively). The formulas were subjected to evaluation procedures including the pharmaceutical properties and the antimicrobial activity in comparison to commercial formula “F”. Results indicated that all formulas had good pharmaceutical properties. F3 showed the best inhibition against the growth of S mutans (diameter of inhibition =  19,25 + 0,50 mm) while that of the commercial toothpaste “F” was (20,0 + 0,00 mm) , which was significantly different from that of the toothpaste  base at probability 0.05.
PENGEMBANGAN POTENSI RHODOMYRTONE SEBAGAI BAHAN AKTIF SEDIAAN TOPIKAL Fahmi, Rizal; Rullah, Kamal; Rahmat, Rosita Dewi; Lucida, Henny; Manjang, Yunazar; Hj. Lajisc, Nordin; Dachriyanus, .
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 6, No 1 (2012)
Publisher : Indonesian Research Gateway

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Rhodomyrtone, an antibacterial constituent was isolated from the active fraction of theleaves extract of Karamuntiang, Rhodomyrtus tomentosa (Aiton) Hassk. In this presentstudy, the topical cream formula of rhodomyrtone 2% in vanishing cream was evaluated byin vitro and in vivo preclinical test. The in vitro test was peformed against Staphylococcusaureus ATTC 6538 and Staphylococcus epidermidis ATTC 12228 by using disk agardiffusion method, while the in vivo test was evaluated on the surface of skin infection area ofthe rabbit caused by Staphylococcus aureus. Both these tests were guided bychloromphenicol 2% cream as a comparison. The topical cream of rhodomyrtone 2% invanishing cream showed diameters of inhibition zones of 15 mm and 26 mm towardStaphylococcus aureus and Staphylococcus epidermidis respectively. These diffusions werelower than inhibition zones of chloromphenicol 2% cream which has 30 mm and 32 mm forthe same bacterias in the same condition. The in vivo test showed that rhodomyrtone 2%topical cream can reduced that skin infection and did not caused irritation on the testedrabbits.ABSTRAKRhodomyrtone adalah suatu konstituen antibakteri fraksi aktif ekstrak daun karamuntiang,Rhodomyrtus tomentosa (Ait) Hassk. Pada penelitian ini telah dilakukan uji preklinisterhadap krim sediaan topikal Rhodomyrtone 2% dalam vanishing cream. Uji preklinissecara in vitro menggunakan media agar dan Staphylococcus aureus ATTC 6538 danStaphylococcus epidermidis 12228 sebagai bakteri uji, sedangkan secara in-vivo dilakukanterhadap kulit pada kelinci yang di infeksi dengan Staphylococcus aureus. Kedua uji inimenggunakan krim kloromfenikol 2% sebagai pembanding. Krim sediaan topikalrhodomyrtone 2% dengan basis vanishing cream memberikan diameter hambatan berturutturut15 mm dan 26 mm terhadap Staphylococcus aureus dan Staphylococcus epidermidis.Difusi ini lebih rendah dibanding sediaan krim kloromfenikol 2% yang memberikan diameterhambatan 30 mm dan 32 mm, masing-masing untuk Staphylococcus aureus danStaphylococcus epidermidis pada kondisi yang sama. Selanjutnya uji secara in vivomenunjukkan bahwa krim sediaan topikal rhodomyrtone 2% dapat mengurangi infeksi kulitdan tidak menimbulkan iritasi pada kelinci percobaan.