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Effect of Zn Supplemented to Immune Status Premenopausal Women Intervented with Isoflavoned Drinking WINARSI, HERY; MUCHTADI, DEDDY; ZAKARIA, FRANSISKA RUNGKAT; PURWANTO, AGUS
HAYATI Journal of Biosciences Vol 12, No 2 (2005): June 2005
Publisher : Bogor Agricultural University, Indonesia

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Abstract

The research was conducted to find out the effect of Zn supplement to immune status of premenopausal women intervented with isoflavoned drinking. Respondents were 22 women, more than 40 year of age. They were divided into two groups, i.e. 11 women intervented with isoflavone, and other 11 women intervented with isoflavone and 8 mg Zn. The activities of SOD, catalase and GPX were determined by spectrophotometer, thymulin levels by ELISA, whereas Zn levels by AAS. Result showed that Zn had significantly increased SOD lymphocyte activities (p=0.002) and thymulin plasma (p=0.011). Zn had increased catalase (p=0.103) and GPX (p=0.322) as well, but Zn plasma had decreased (0.163). It was indicated that Zn had improved the immune status by increasing lymphocyte and thymus cells activities.
Strategi Pemberian Fasilitas Kredit Modal Kerja kepada Pengusaha Industri Kecil Menengah Berorientasi Ekspor (Kasus di BNI Jakarta) Sulistya, Yudha Iman; Hubeis, Musa; Zakaria, Fransiska Rungkat
MANAJEMEN IKM: Jurnal Manajemen Pengembangan Industri Kecil Menengah Vol 6, No 1 (2011): Manajemen IKM
Publisher : Institut Pertanian Bogor

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Abstract

In the middle of 1997 Indonesia’s economic was destroyed by a long economy crisis which had influenced the US foreign currency (USD) against Rupiah (IDR). On the other side, Small and Medium Enterprises (SME) still survives and grows absorbing more than 35 million labors active in agriculture sectors. Up to this time, almost 60% of domestic earnings bruto comes from SME commerce and agriculture. SME is expected to expand, from what initially in the form of a small industry unit into a middle industry unit and hereinafter become a big industry unit. Along with the growth of entrepreneurs of SME, the number of absorbed labors also increased equal to 20% per year consisting of small industries 15,9% and middle industries 4,1%. The objective of this research is to analyze the characteristic and behavior of SME having effect on financial pattern, study constraints in giving working capital loan, determining financial pattern according to characteristics of SME, and also compile strategy for BNI in improving market compartment and facing competition in banking industry. Data analysis was done with methods of descriptive qualitative and analysis of strenghts, weaknesses, opportunities and threats (SWOT). According to the responses stated in the questionnaire by the clients of BNI, 84.5% expressed that working capital loan was  proper to SME’s, 82,5% expressed easy access to bank and there was relationship between bank and SME’s important. Meanwhile 77,5% expressed constraints in distribution and application of working capital loan from BNI.According to the analysis of chi square with db = 14, and expected result frequency (fh), working capital loan was proper to UKM with highly significant effect with chi square = 26,72, and easy access to bank influenced the distribution of working capital loan to UKM with highly significant effect with chi square = 25,48. There were constraint in distribution of working capital loan which was also highly significant with chi square = 28,55. The results of total and internal strategic factor score and strategic factor score of external with total score of IFAS = 2,55 and EFAS = 2,30 by matrix of IE indicates that BNI resides in condition of growth or of stability. The result of SWOT analysis, showed that there were alternative strategies to improve BNI performances, including : opening more center of SMEs credit (SKC) in and outside Java, cooperation with local government and upgrading services.   Key words: export, SME’s, strategic factor, working capital loan
Pengembangan Usaha Industri Jamu dan Minuman PD. Budi Lestari di Jakarta Prasetyo, Tanjung; Monintja, Daniel R.; Zakaria, Fransiska Rungkat
MANAJEMEN IKM: Jurnal Manajemen Pengembangan Industri Kecil Menengah Vol 4, No 2 (2009): Manajemen IKM
Publisher : Institut Pertanian Bogor

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Abstract

The aim of this study is to identity successful business conducts carried out by the company. The successful business conducts identified are: (1) Employing skillful marketing personnel, (2) Having a wide marketing channels, (3) Application of production contract, (4) Utilizing brokers in marketing the product, (5) Utilizing secondhand containers to reduce cost. The method used from this study is SWOT analysis with primary and secondary data, which are collected through literature and interview. Based on the results of the SWOT analysis, there were some suggestions to PD. Budi Lestari in order to develop its business by : (1) Increasing working capital, (2) Increasing the quality of human resources, (3) Making promotions, (4) Increasing the machine technologies utilizing, (5) Finding new bottles using altenatives in solving problem of getting used bottles, (6) Using labels that includes the special qualities of the drinks to explain the characteristic and quality from each product made, (7) Selecting the distribution of used bottles facilities. Beside that, suggestions given from this study can be an input to the company in raising its sales volume as an effort to fulfill market’s demand, includes mini and super markets.   Key words: business conducts, SWOT, market’s demand
Ginger Root Bioactive Compounds Increased Cytolitic Response of Natural Killer (NK) Cells Against Leucemic Cell Line K-562 In Vitro ., Tejasari; Zakaria, Fransiska Rungkat
Jurnal Teknologi Dan Industri Pangan Vol 17, No 2 (2006): Jurnal Teknologi dan Industri Pangan
Publisher : Departemen Ilmu dan Teknologi Pangan, IPB Indonesia bekerjasama dengan PATPI

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Abstract

Natural killer (NK) cell, a kind of lymphocyte cells, plays an important role in attacking infectious, immature, and cancer cell. Its function could be modulated by food bioactive compounds. This experiment was conducted to investigate the effects of ginger root bioactive compounds such as oleoresin, gingerol, and shogaol on cytolitic response of NK cell in vitro. Lymphocyte cells were isolated by centrifugation on ficoll-hypaque density (1,77 ?0,001 g/ml) method. Leukemic cells line K-562 as target cells(TC) labelled by [3H]-timidin, together with lymphocyte as effector cell (EC) were cultured in two ratio levels of EC : TC equal to 1:50 and 1:100), and two culture conditions, for 4 hours, respectively. Paraquate dichloride (1,1-dimethyl-4,4-bipyridilium dichloride) 3 mM was used to induce stress oxidative circumstance. Cytolytic capacity of NK cells was determined by percentage of TC lysed by NK cells, in normal and oxidative stress conditions. Statistical analysis showed that the effects of ginger bioactive compounds on cytolytic response of NK cell depended on the culture conditions, as shown by cultures in the presence of oleoresin, and gingerol, but not shogaol. In the lymphocyte culture without stress oxidative, oleoresin, gingerol and shogaol compounds increased significantly cytolytic response of NK cells cultured at a ratio of TC : EC equal to 1:50, with the highest increament of 65 % at oleoresin concentration of 50 ?g/ml. However, in culture at a ratio of TC : EC equals to 1:100, only oleoresin at a concentration of 50 ?g/ml increased significantly cytolytic response of NK cells with the highest increament of 8 %. Shogaol did not affect significantly NK cells cytolytic response. Under stress oxidative conditions, shogaol increased significantly cytolytic response of NK cells cultured at a ratio of TC:EC equal to 1:50, but the highest increament of 56 % , was by oleoresin at concentration of 50 ?g/ml. Meanwhile, oleoresin and gingerol did not increased significantly cytolytic response of NK cells. At a culture- ratio of TC: EC equal to 1:100, gingerol increased significantly cytolytic response of NK cells of 21 % at a concentration of 50 ?g/ml. However, oleoresin did not increased significantly cytolytic response of NK cells. In contrast, shogaol decreased significantly cytolytic response of NK cell with the highest decreament of 16 % at 200 ?g/ml. These findings verified that ginger root bioactive compounds increased cytolityc response of NK cells in destroying cancer cells, at certain conditions and concentrations, especially at low concentrations. Key words : ginger bioactive compound, oleoresin, gingerol, shogaol, stress oxidative, effector cell, target cell, natural killer cell, cytolytic response
In Vitro Antioxidant Activity of Stabilized Rice Bran and Its Fraction Damayanti, Evy; Zakaria, Fransiska Rungkat; Syarief, Hidayat; Wijaya, C Hanny; Damardjati, Djoko Said
Jurnal Teknologi Dan Industri Pangan Vol 15, No 1 (2004): Jurnal Teknologi dan Industri Pangan
Publisher : Departemen Ilmu dan Teknologi Pangan, IPB Indonesia bekerjasama dengan PATPI

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Abstract

Some Researches indicated that oryzanol had antioxidant activity, however, the information about the oryzanol role in the prevention of low density lipoprotein (LDL) and human lymphocyte from oxidation under oxidative stress was still limited. The objective of this study was the investigate the antioxidant activity of oryzanol at concentrations based on rice bran beverage model in preventing LCL and lymphocyte from oxidation. Human plasma were supplemented with the samples of : rice bran oil (RBO), unsaponifiable matter and oryzanol IR-64, oryzanol IR-64 3x and oryzanol standard at the concentrations of 308.3, 22.2, 5.2, 10.4, and 10.4 µg/ml, respectively. Afterward, the human LDL were collected by ultracentrifuge and diluted until a concentration of 200 µg protein/ml was reached. Human LDL isolates were then oxidized with CuSO4 5 µM for measuring antioxidant activity of the sample. The length of incubation, H2O2 concentration, period of sample supplemented into human lymphocyte culture were determined before the antioxidant activity of RBO and its fraction in lymphocyte was measured. The samples used in the lymphocyte were RBO IR-64, unsaponifiable matter IR-64, and oryzanol standard at the concentrations of 133.2 – 2, 132.0 µg/ml, 9.6 – 153.6 µg/ml, and 2.4 – 37.7 µg/ml, consecutively. The result showed that malonaldehyde concentration in human LDL decreased significantly (α = 0.05), 15 – 41% and 39 – 56% compared to the control. The absorbance of living lymphocyte cell in culture was not influenced by the type and concentration of RBO and its fraction. The addition of hydrogen peroxide (H2O2) 3 mM into culture sifnificantly lowered the absorbance as compared to culture without (H2O2). Key words :Oryzanol, oxidative stress, LDL-oxidized, lymphocyte and antioxidant activity.
PENGARUH MINUMAN BEROKSIGEN TERHADAP SISTEM IMUN, KADAR MALONALDEHIDA DAN PERFORMA RESPONDEN MAHASISWA OLAHRAGAWAN [Effect of Oxygenated Water on Immune System, Malonaldehyde Content and Student-Athlete Performance] Refdi, Cesar Welya; Zakaria, Fransiska Rungkat; Giriwono, Puspo Edi
Jurnal Teknologi Dan Industri Pangan Vol 25, No 1 (2014): Jurnal Teknologi dan Industri Pangan
Publisher : Departemen Ilmu dan Teknologi Pangan, IPB Indonesia bekerjasama dengan PATPI

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Abstract

PENGARUH MINUMAN BEROKSIGEN TERHADAP  SISTEM IMUN, KADAR MALONALDEHIDA DAN PERFORMA RESPONDEN MAHASISWA OLAHRAGAWAN [Effect of Oxygenated Water on Immune System, Malonaldehyde Content and Student-Athlete Performance] Cesar Welya Refdi, Fransiska Rungkat Zakaria* dan Puspo Edi Giriwono Departemen Ilmu dan Teknologi Pangan, Fakultas Teknologi Pertanian, Institut Pertanian Bogor, Bogor   Diterima 23 Agustus 2013 / Disetujui 01 Juli 2014 ABSTRACT Exercise requires more oxygen input and cannot be fully obtained through breathing. The body has a homeostatic system, when more ATP is needed, the more oxygen is required by the body. Limited supply of oxygen such as those happens in athlete’s body automatically switches the respiration from aerobic into anaerobic. This situation results in building up of lactic acid which in turn lowers the energy for cellular metabolism as well asenergy for exercise. The purpose of this study was to assess the effects of short-term and long-term drinking of oxygenated water on lactic acid and energy expenditure (EE) in exercise performance; Cluster of Differentiation-4 (CD4), CD8, CD56, Interleukin-6 (IL-6) contents; and level of malonaldehyde. During short-term intervention, 12 male student volunteers drank oxygenated (50, 80 and 130 ppm) water and normal mineral water, 15 minutes before treadmill and after treadmill (10 Kmh). The lactic acid concentration was measured before and after treadmill, and 5 minutes after the reconsumption of the oxygenated water. During long-term intervention, 17 male student volunteers drank oxygenated (100 ppm) water twice a day for 21 days. The blood plasma and lymphocyte sampled before and after intervention were analyzed for the same parameters. The results showed that oxygenated water had no effect on lactic acid accumulations and EE. Similarlyt he long-term study showed that oxygenated water did not affect CD4 and CD8, had no harmful effect on IL-6 and malonaldehyde, yet it significantly increased the CD56 content.
PENGARUH KONSUMSI MINUMAN BEROKSIGEN TERHADAP INFLAMASI DAN KAPASITAS ANTIOKSIDAN PENDERITA PENYAKIT-PARU-OBSTRUKTIF-KRONIK (PPOK) [Influence of Oxygenated Water Consumption in Chronic-Obstructive-Pulmonary-Disease (COPD) Patients] Zakaria, Fransiska Rungkat; Azni, Intan Nurul; Syamsir, Elvira; KM., Amalia; Yamani, Cholid
Jurnal Teknologi Dan Industri Pangan Vol 25, No 1 (2014): Jurnal Teknologi dan Industri Pangan
Publisher : Departemen Ilmu dan Teknologi Pangan, IPB Indonesia bekerjasama dengan PATPI

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Abstract

PENGARUH KONSUMSI MINUMAN BEROKSIGEN TERHADAP INFLAMASI DAN KAPASITAS ANTIOKSIDAN PENDERITA PENYAKIT-PARU-OBSTRUKTIF-KRONIK (PPOK) [Influence of Oxygenated Water Consumption in Chronic-Obstructive-Pulmonary-Disease (COPD) Patients] Fransiska Rungkat Zakaria1), Intan Nurul Azni2)*, Elvira Syamsir2), Amalia KM.3) dan Cholid Yamani3) 1) Departemen Ilmu dan Teknologi Pangan, Fakultas Teknologi Pertanian, Institut Pertanian Bogor, Bogor 2) Program Studi Ilmu Pangan, Fakultas Teknologi Pertanian, Institut Pertanian Bogor, Bogor 3) Klinik dr. Katili, Jl. Raya Dramaga, Bogor Diterima 01 Agustus 2013 / Disetujui 05 Februari 2014 ABSTRACT Chronic Obstructive Pulmonary Disease (COPD) is one of the leading cause of death in the world that represents an important public health problem. Oxygenated water is water added with high concentration of oxygen such that the oxygen concentration is higher than normal water. The objective of this study was to assess the influence of oxygenated water consumption on the alteration of proinflammatory cytokines (TNF-α, IL1-β, and IL6) and antioxidant capacity of COPD patients. Sixteen COPD patients were allowed to drink 385 mL oxygenated water two times a day for 21 days. The alteration of proinflammatory cytokines and antioxidant capacity are measured by comparing plasma concentration before and after intervention. The results suggest that oxygenated water consumption significantly reduce proinflammatory cytokines plasma (TNF-α, IL1-β, and IL6) at 5% significance level with 81.25% of respondents having lower TNF-α, 75% of respondents with lower IL-1β, and 62.25% of respondents having lower the IL-6 in plasma concentration after 21 days intervention. There were 43.75% of respondents with decreased antioxidant capacity concentration. However, it was not significant at the 5% level significance. Decrease in antioxidant capacity was probably a resulted from poordiet and drugs consumption during the intervention period.
Pengembangan Usaha Industri Jamu dan Minuman PD Budi Lestari di Jakarta Prasetyo, Tanjung; Monintja, Daniel R.; Zakaria, Fransiska Rungkat
MANAJEMEN IKM: Jurnal Manajemen Pengembangan Industri Kecil Menengah Vol 4, No 2 (2009): Manajemen IKM
Publisher : Institut Pertanian Bogor

Show Abstract | Original Source | Check in Google Scholar | Full PDF (135.532 KB)

Abstract

The aim of this study is to identity successful business conducts carried out by the company. The successful business conducts identified are: (1) Employing skillful marketing personnel, (2) Having a wide marketing channels, (3) Application of production contract, (4) Utilizing brokers in marketing the product, (5) Utilizing secondhand containers to reduce cost.The method used from this study is SWOT analysis with primary and secondary data, which are collected through literature and interview.Based on the results of the SWOT analysis, there were some suggestions to PD. Budi Lestari in order to develop its business by : (1) Increasing working capital, (2) Increasing the quality of human resources, (3) Making promotions, (4) Increasing the machine technologies utilizing, (5) Finding new bottles using altenatives in solving problem of getting used bottles, (6) Using labels that includes the special qualities of the drinks to explain the characteristic and quality from each product made, (7) Selecting the distribution of used bottles facilities.Beside that, suggestions given from this study can be an input to the company in raising its sales volume as an effort to fulfill market’s demand, includes mini and super markets.
Faktor-Faktor yang Mempengaruhi Penerapan Cara Produksi yang Baik dan Standar Prosedur Operasi Sanitasi Pengolahan Fillet Ikan di Jawa Yuwono, Budi; Zakaria, Fransiska Rungkat; Pandjaitan, Nurmala Katrina
MANAJEMEN IKM: Jurnal Manajemen Pengembangan Industri Kecil Menengah Vol 7, No 1 (2012): Manajemen IKM
Publisher : Institut Pertanian Bogor

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Abstract

In order to increase quality and safety of fish fillet products, Directorate General of Fisheries Product Processing and Marketing, Ministry of Marine Affairs and Fisheries, introduced Good Manufacturing Practices (GMP) and Sanitation Standard Operating Procedures (SSOP) of fish fillet to the industry in Indonesia, including in Java. Recently, some processor who already applied GMP and SSOP do not continue the application of GMP and SSOP. Due this situation, this report is to find all factors that influence continuity application of GMP and SSOP processes of fish fillet and to see the recent condition of application of GMP and SSOP in fillet processing plants which do not continue (BM).  Processing and analyzing the data using description method and pre-requisite analysis. The respondents of this research are 26 fish fillet processing plants in Java which are divided into 15 fish fillet processing plants that do not continue the application of GMP and SSOP (BM) and 11 fish fillet processing plants that are still continuing the application (LM). The factors that influence continuity application of GMP and SSOP in fish fillet processing plants that do not continue the application (BM) can be divided into internal factors which are lack of education (73%), and lack of experience (100%), external factors which are lack of government policies in socialization (66,66%),  lack of portable water (87%) and ice supply (67%), lack of cold chain system facility (74%), lack of government policies in training (60%), monitoring (80%), lack of low enforcement (86%), no market requirement (100%), and characteristic of innovation factors which are no relative advantages in implementing GMP and SSOP (86,67%), no compatibility (80%), and the complexity of GMP and SSOP (73,33%).  Base on pre requisite analysis, the status of GMP and SSOP in 15 fish fillet processing plants that do not continue (BM) the application is very bad as shown in high minor and mayor failure, and also serious and critical failure more than tolerance level. In order to support the application of GMP and SSOP in 15 fish fillet processing plants that do not continue the application (BM), it is suggested to increase the frequency of socialization, training, monitoring and technical counseling in special locus, facilitating water and ice supply, enforce the GMP and SSOP label in fisheries products in domestic market, and increasing education regarding the importance of GMP and SSOP application in fish fillet industry to the public
Strategi Pemberian Fasilitas Kredit Modal Kerja kepada Pengusaha Industri Kecil Menengah Berorientasi Ekspor (Kasus di BNI Jakarta) Sulistya, Yudha Iman; Hubeis, Musa; Zakaria, Fransiska Rungkat
MANAJEMEN IKM: Jurnal Manajemen Pengembangan Industri Kecil Menengah Vol 6, No 1 (2011): Manajemen IKM
Publisher : Institut Pertanian Bogor

Show Abstract | Original Source | Check in Google Scholar | Full PDF (144.84 KB)

Abstract

In the middle of 1997 Indonesia’s economic was destroyed by a long economy crisis which had influenced the US foreign currency (USD) against Rupiah (IDR). On the other side, Small and Medium Enterprises (SME) still survives and grows absorbing more than 35 million labors active in agriculture sectors. Up to this time, almost 60% of domestic earnings bruto comes from SME commerce and agriculture. SME is expected to expand, from what initially in the form of a small industry unit into a middle industry unit and hereinafter become a big industry unit. Along with the growth of entrepreneurs of SME, the number of absorbed labors also increased equal to 20% per year consisting of small industries 15,9% and middle industries 4,1%. The objective of this research is to analyze the characteristic and behavior of SME having effect on financial pattern, study constraints in giving working capital loan, determining financial pattern according to characteristics of SME, and also compile strategy for BNI in improving market compartment and facing competition in banking industry. Data analysis was done with methods of descriptive qualitative and analysis of strenghts, weaknesses, opportunities and threats (SWOT). According to the responses stated in the questionnaire by the clients of BNI, 84.5% expressed that working capital loan was  proper to SME’s, 82,5% expressed easy access to bank and there was relationship between bank and SME’s important. Meanwhile 77,5% expressed constraints in distribution and application of working capital loan from BNI.According to the analysis of chi square with db = 14, and expected result frequency (fh), working capital loan was proper to UKM with highly significant effect with chi square = 26,72, and easy access to bank influenced the distribution of working capital loan to UKM with highly significant effect with chi square = 25,48. There were constraint in distribution of working capital loan which was also highly significant with chi square = 28,55. The results of total and internal strategic factor score and strategic factor score of external with total score of IFAS = 2,55 and EFAS = 2,30 by matrix of IE indicates that BNI resides in condition of growth or of stability. The result of SWOT analysis, showed that there were alternative strategies to improve BNI performances, including : opening more center of SMEs credit (SKC) in and outside Java, cooperation with local government and upgrading services