Articles

UJI EFEK ANTIPIRETIK KOMBINASI EKSTRAK ETANOL HERBA SAMBILOTO (Andrographis paniculata Burm.f. Nees.) DAN EKSTRAK ETANOL DAUN BELIMBING WULUH (Averrhoa bilimbi L.) PADA TIKUS PUTIH JANTAN (Rattus norvegicus) Ibrahim, Nurhalifah; Yusriadi, Yusriadi; Ihwan, Ihwan
Online Journal of Natural Science FMIPA Vol 3, No 3 (2014): Volume 3 Number 3 (December 2014)
Publisher : Online Journal of Natural Science FMIPA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.2012/

Abstract

This research is about antipyretic effect of combination ethanol extract of sambiloto (Andrographis paniculata Burm.f. Nees.) herbsand ethanol extract of  belimbing wuluh (Averrhoa bilimbi L.) leaves in white male rats (Rattus norvegicus)which induced by 5 % pepton, in order to know the effect of combination and to determine the most effective dose as an antipyretic. Extract was prepared by maceration method using 70% ethanol. White rats were grouped into 7 difference treatment. Each rat was induced by using 5% peptone in dose of 250 mg/200 g Body Wight (BW). The first group was given Na CMC as a negative control. The second group was given paracetamol as a positive control. Groups of 3rd, 4th, 5th, 6th and 7th were given a combination of ethanol extract sambiloto (A. paniculata Burm.f. Nees.) herbs and ethanol extract belimbing wuluh (A. bilimbi L.) leaves in doses of (200 + 0) mg/200 g BW,  (150 + 50) mg/200 g BW, (100 + 100) mg/200 g BW, (50 + 150) mg/200 g BW, and  (0 + 200) mg/200 g BW, respectively. Temperature measurements of antipyretic were done for 3 hours in 30 minutes interval. Temperature data were statistically analysed using ANOVA (Analisys Of Variance) one way Anova method. The result of research was showed that combinationextract could reduce thefever. The most effective combination as an antipyretic was ethanol extract of sambiloto (A. paniculata Burm.f. Nees.) Herbs 150 mg and ethanol extract of belimbing wuluh (A. bilimbi L.) leaves 50 mg (150 + 50) mg/200 g BW. The dose has antipyretic effects that was not significant different to the positive control group(paracetamol treatment).
Formulasi Mikroemulsi Ekstrak Bawang Hutan dan Uji Aktivitas Antioksidan Sulastri, Evi; Oktaviani, Cristadeolia; Yusriadi, Yusriadi
JURNAL PHARMASCIENCE Vol 2, No 2 (2015): JURNAL PHARMASCIENCE
Publisher : JURNAL PHARMASCIENCE

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRAKBawang hutan mengandung senyawa metabolit sekunder golongan naftokuinon (elecanacin, eleutherin, elutherol, eleutherinon) yang diketahui memiliki aktivitas antioksidan. Beberapa penelitian telah melaporkan tentang aktivitas antioksidan ekstrak yang diformulasi dalam bentuk sediaan tablet dan krim. Penelitian ini bertujuan mengembangkan formula dalam bentuk  mikroemulsi sebagai penghantaran yang efektif untuk mempertahankan aktivitas antioksidan ekstrak bawang hutan.  Mikroemulsi dibuat dengan menggunakan virgin coconut oil (VCO) sebagai fasa minyak, Tween 80 sebagai surfaktan dan gliserin sebagai kosurfaktan. Uji stabilitas fisik yang dilakukan terhadap sediaan meliputi uji organoleptik, pH, viskositas, sentrifugasi dan ukuran globul. Uji aktivitas antioksidan dilakukan secara in-vitro menggunakan metode peredaman DPPH dan menggunakan asam askorbat sebagai kontrol positif. Data hasil pengukuran dianalisis secara statistik menggunakan metode t-student. Hasil penelitian menunjukkan mikroemulsi dengan tampilan visual yang jernih dan ukuran globul < 5 μm. Meskipun sediaan mengalami perubahan pH dan viskositas tapi tidak terjadi pemisahan fase pada penyimpanan selama 28 hari. Hasil uji aktivitas antioksidan mikroemulsi ekstrak secara berturut-turut pada penyimpanan suhu 33°C dan 40°C: pada hari ke-1 menunjukkan nilai IC50 sebesar 101,167 μg/mL dan 89,956 μg/mL  sedangkan hari ke-35 sebesar 127,254 μg/mL dan 101,996 μg/mL. Berdasarkan hasil tersebut, aktivitas antioksidan ekstrak bawang hutan masuk dalam kategori kuat sampai sedang. Kata kunci  : Mikroemulsi, ekstrak bawang hutan (Eleutherine bulbosa (Mill.)Urb.), mutu fisik, antioksidan.  A B S T R A C TBawang hutan have contain secondary metabolite naftokuinon class (elecanacin, eleutherin, elutherol, eleutherinon) which known have antioxidant activities. Some of research reported antioxidant activity of extract which formulated in tablet and cream dosage form. The aim of this study was to developed effectively delivery system of bawang hutan in microemulsion  for maintenance its antioxidant activity. A microemulsion was prepared using an oil phase of  Virgin Coconut Oil (VCO), a surfactant of tween 80 and a  cosurfactant of gliserin. Evaluation of physical stability the microemulsions included analysis of organoleptic, viscosity, centrifugation and globul size. The antioxidant activities was evaluated by in vitro experiments using scavenging asssay of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals and using ascorbic acid as positif control. The evaluation result were statistically analyzed using the t-student. The results indicated that a clear microemulsion and the globul size was < 5 μm. Even though, the pH and viscosity were not stable but there are not separated phase after centrifugation on 28 day storage. The antioxidant activity of microemulsion at 33°C dan 40°C storage respectively showed that IC50 values on day 1 is 101.167 μg/mL and 89.956 μg/mL, on day 35 is 127.254 μg/mL and 101.996 μg/mL. According to the result, antioxidant activity of bawang hutan extract is categorized into the powerful to moderate antioxidants. Keywords        :   Microemulsion, Eleutherine bulbosa extract (bawang hutan), Physical stability, Antioxidant.
FORMULASI KRIM ANTIOKSIDAN EKSTRAK DAUN KAPAS (Gossypium sp.) Hasniar, Hasniar; Yusriadi, Yusriadi; Khumaidi, Akhmad
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Vol 1, No 1 (2015): (March 2015)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2015.v1.i1.4830

Abstract

Gossypium sp. leaf is one of the plants that contain flavonoids that can act as antioxidants. This study aims to look at the effect of combination of the stearic acid and triethanolamine which function as emulsifier in creams and determine antioxidant activity of cream Gossypium sp. leaf extract. Cream is formulated with a variety of stearic acid and triethanolamine emulsifier that F1 (8%: 2%), F2 (12%: 3%), F3 (16%: 4%). Tests carried out at the first day and the 28th days. Evaluation preparations include organoleptic test, homogeneity, viscosity, pH, and type of the cream. The results showed that the variation of concentration emulsifier that fill quality preparations with some parameters such as organoleptic, homogeneity, the type of cream and viscosity. pH of cream does not qualify are 4.5-6, but still in the neutral pH range (pH ± 7). Antioxidant activity of the cream has a large reduce power at the first day DPPH reduce percent value for F1, F2, and F3 are 80,73%, 83,05% and 83,51% respectively, while after the storage at the 28th days DPPH reduce percent value for F1, F2, and F3 are 80,43%, 82,49% and 79,02% respectively. Preparation creams that fill physical quality cream is F1 by using emulsifier triethanolamine and stearic acid with a concentration of 8%: 2%
GEL ANTI JERAWAT EKSTRAK DAUN BUTA-BUTA (Excoecaria agallocha L.) DAN PENGUJIAN ANTIBAKTERI Staphylococcus epidermidis Borman, Ika Olivia; Yusriadi, Yusriadi; Sulastri, Evi
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Vol 1, No 2 (2015): (October 2015)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2015.v1.i2.6215

Abstract

Buta-Buta (Excoecaria agallocha L.) leaf is a type of mangrove plants that has antibacterial activity againtsbacteriacausing acne, Staphylococcus epidermidis,. This study aims to formulate buta-buta leaf extract with the concentration of 12.5 % into anti-acne gel using two gels, namely HPMC 8% (Formula 1) and Carbopol 940 2%(Formula 2). Antibacterial activity test was carried out by agar diffusion method using well. The stability and antibacterial activity data during 28 days were analyzed statistically using unpaired t-student with a degree of confidence of 95% (α = 0.05). The evaluation results of anti-acne gel form of buta-buta leaf extract in Formula 2 showedbetter characteristics than Formula 1, which include organoleptic examination, homogenity, pH and viscosity during 28 days. The antibacterial test showed the diameter of inhibition zone of Formula 2 is 11.03 mm ±0,01. The statistic analysis showed a significant difference between Formula 2 with a positive control (klindamisin gel).
PENGARUH GEL EKSTRAK DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav) TERHADAP PENYEMBUHAN LUKA BAKAR PADA KELINCI (Oryctolagus cuniculus) Ulviani, Fina; Yusriadi, Yusriadi; Khaerati, Khildah
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Vol 2, No 2 (2016): (October 2016)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2016.v2.i2.5977

Abstract

Research on Gel Formulation of red betel leaf extract (Piper crocatum Ruiz & Pav) for the treatment of burn wounds in rabbits (Oryctolagus cuniculus) has been conducted. This study aimed to determine variation’s effect of concentration in gel of red betel leaf extract for the treatment of burn wounds in rabbits which had been wounded using hot metal. In this study, the viscous extract was formulated into gel with concentrations of 1%, 2% and 3%. The Gel’s Physical quality evaluation included organoleptic, pH, homogeneity and dispersive ability tests on day 0 until day 28. The gel activity test was performed on 5 rabbits divided into five treatment groups. Each rabbit was burn-wounded using hot metal plate at diameter of 20 mm. Each group was given five wounds consisting of a negative control, 1%, 2%, 3% of extract formula and a positive control. The diameter measurement of the wounds was done on the 1st, 3rd, 5th, 7th, 9th and the 21st day. Data of wound healing percentage was statistically analyzed with Two-Way ANOVA. The results showed that the gel with 3% of red betel leaf extract of which percentage of healing as much as 85.81% compared to gel extract 1% and 2% with percentage 65,32% dan 76,58%.
UJI AKTIVITAS REPELAN LOTION EKSTRAK ETANOL KULIT BUAH LANGSAT (Lansium parasiticum Osbeck.) TERHADAP NYAMUK Aedes aegypti Pebrianti, Pebrianti; Yusriadi, Yusriadi; Faustine, Ingrid
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Vol 1, No 2 (2015): (October 2015)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2015.v1.i2.6242

Abstract

Repellents are substances that can provide protection from nuisance insects by interfering with its sensory function. Lanzones fruit is known to contain triterpenoids which have activity as repelan. This study was to examine the repellent activity and to determine protection capacity of lotion containing ethanol extract of lanzones (Lansium parasiticum) peel against  Aedes aegypti mosquitoes. The ethanol extract was obtained by macerating the peel with 96% ethanol. The lotion is prepared in three extract concentrations, 15%; 20%; and 25% followed by its physical stability evaluation and activity examination. Data of pH, viscosity and dispersive capacity evaluation obtained were statistically analyzed using paired samples t-test. The results showed that the lotion preparations are stable on organoleptic observation and homogeneity evaluation. The statistical analysis of pH, viscosity, and the dispersive capacity evaluations showed that their results are significantly different after day 0 to day 28 storage (p> 0.05). Repellent activity examination of the lotion was carried out for 4 hours, using the Aedes aegypti mosquitoes. Of the three concentrations examined, each concentration has different repellent activity that concentration of 15% and 20% indicated a 100% protection up to 1 minute, and concentration of 25% indicated up to 135 minutes
Optimasi Pembentuk Film Polivinil Alkohol dan Humektan Propilen Glikol pada Formula Masker Gel Peel off Sari Buah Labu Kuning (Cucurbita moschata Duchesne) sebagai Antioksidan Andini, Tricia; Yusriadi, Yusriadi; Yuliet, Yuliet
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Vol 3, No 2 (2017): (October 2017)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.0.v0.i0.8773

Abstract

Telah dilakukan penelitian tentang formulasi dalam bentuk sediaan masker gel peel-off. Penelitian ini bertujuan untuk mengetahui konsentrasi optimum polivinil alkohol sebagai pembentuk film dan propilen glikol sebagai humektan terhadap sifat fisik dan kimia sediaan masker gel peel-off sari buah labu kuning, stabilitas formula optimummasker gel dan aktivitas antioksidan sediaan. Formula optimum yang didapatkan yaitu formula 1 dengan konsentrasi PVA 10%  dan PG 10% kemudian dilakukan evaluasi karakteristik mutu fisik kimia dan stabilitas meliputi pengujian daya sebar, pH, viskositas dan lama pengeringan. Pengamatan dilakukan tiap minggu selama 4 minggu penyimpanan pada suhu ruang. Data yang diperoleh dianalisis secara deskriptif dan secara statistik menggunakan metode paired sample t test. Hasil penelitian masker gel peel-off pada formula optimum menunjukkan sediaan stabil selama penyimpanan dimana tidak terjadi perubahan yang signifikan pada tiap parameter uji. Aktivitas antioksidan gel masker peel-off tergolong kuat yang dinyatakan dengan peresen peredaman formula optimum pada hari ke- 2 adalah 75,18% dan 73,37% pada hari ke- 30 setelah penyimpanan pada suhu ruang
FORMULASI SEDIAAN SABUN CAIR ANTIBAKTERI MINYAK ATSIRI DAUN KEMANGI (Ocimumamericanum L.) DAN UJI TERHADAP BAKTERI Staphylococcus epidermidis dan Staphylococcus aureus Abu, Febry Astuti; Yusriadi, Yusriadi; Tandah, Muhammad Rinaldhi
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Vol 1, No 1 (2015): (March 2015)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2015.v1.i1.4835

Abstract

Basil (Ocimum americanum L.) is a plant that has antibacterial activity against Staphylococcus aureus and Staphylococcus epidermidis that is a bacteria can cause infection. Basil contains essential oils that act as an antibacterial. This research aims to formulate the essential oil of basil leaves into a liquid soap, determine antibacterial activity against S.aureus and S.epidermidis bacteria with the agar diffusion method using wells and determine the stability of the preparation. Antibacterial activity data that gain was analyzed by one-way ANOVA with a level of trust 95% followed by Duncan test. The results of the research showed basil essential oil liquid soap preparation has antibacterial activity. The analysis results showed that there were significant differences in the concentration of 2%, 3%, 4%, and the Duncan test results showed no significant difference between the concentration of 4% with control (+). The results of the t-student analysis of liquid soap include viscosity, pH and dispersive capacity does not fill the parameters of stability during the storage period of 28 days
PENGARUH RELATIONSHIP MARKETING YUSRIADI, YUSRIADI
Al-Amwal Vol 6 No 1 (2017): Jurnal Volume 6, No. 1 Juni 2017
Publisher : STEI Iqra Annisa Pekanbaru

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Penelitian ini untuk mengetahui pengaruh relationship marketing yang variabelnya meliputi financial benefit, social benefit dan structural benefit terhadap loyalitas nasabah pada PT. BPRS Berkah Dana Fadhlillah Kabupaten Kampar baik secara parsial maupun secara simultan. Penelitian ini juga bertujuan untuk mengetahui dan menjelaskan berapa persen ketiga variabel tersebut menjelaskan pengaruhnya terhadap loyalitas nasabah. Dengan menggunakan alat analisa regresi berganda, di peroleh hasil variabel financial benefit berpengaruh secara positif terhadap loyalitas nasabah dengan nilai t hitung sebesar 8,763 > t Tabel 1,9796 dan nilai signifikansi sebesar 0,000 < 0,05. Variabel social benefit hasilnya berpengaruh secara negatif terhadap loyalitas nasabah dengan nilai t hitung sebesar 2,234 > t Tabel 1,9796, nilai t hitung negatif, dan nilai signifikansi sebesar 0,027 < 0,05. Variabel structural benefit hasilnya berpengaruh secara negatif terhadap loyalitas nasabah dengan nilai t hitung sebesar 2,332 > t Tabel 1,9796, nilai t hitung negatif, dan nilai signifikansi sebesar 0,021 < 0,05. Untuk nilai F sebesar 29,105 > F Tabel sebesar 2,68 dengan nilai signifikansi sebesar 0,000 < 0,05. Sedangkan nilai determinasi nya yang di sesuaikan (Adjusted R Square) sebesar 0,403 atau sebesar 40,3%. Dari analisis data, secara parsial hasilnya financial benefit berpengaruh positif dan signifikan terhadap loyaltas nasabah. Social benefit berpengaruh negatif dan signifikan terhadap loyalitas nasabah. Social benefit berpengaruh negatif dan signifikan terhadap loyalitas nasabah. Sedangkan secara simultan financial benefit, social benefit dan structural benefit berpengaruh positif dan signifikan terhadap loyalitas nasabah.
DESIMINASI DUA MODEL TEKNOLOGI BIOGAS PADA PETERNAKAN RAKYAT DI KABUPATEN ENREKANG GUNA MENCIPTAKAN MASYARAKAT HEMAT ENERGI Yusriadi, Yusriadi; Irmayani, Irmayani
JURNAL GALUNG TROPIKA Vol 2, No 3 (2013)
Publisher : Fapetrik-UMPAR

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Perkembangan ternak sapi perah khususnya di Kabupaten Enrekang Sulawesi Selatan mengalami perkembangan yang cukup pesat. Banyak kelompok ternak yang mengembangkan kegiatan pada bidang ini. Hasil utama dari sapi perah di Kabupaten Enrekang yaitu Susu yang kemudian diolah menjadi Dangke (makanan khas masyarakat Enrekang). Selain hasil utama ada juga hasil sampingan yang tidak kalah pentingnya yaitu feses dan urin. Feses dan urin penting sebab setiap hari ternak perah mengeluarkan feses dan urin, dan jika dibiarkan begitu saja ini akan menjadi sampah atau limbah yang dapat mencemari lingkungan dan menyebabkan kontaminasi susu yang sudah diperah. Proses ini akan menyebabkan kualitas susu menjadi menurun. Saat ini telah banyak teknologi khususnya pengolahan limbah yang digunakan. Semua teknologi menguntungkan, namun beberapa model teknologi tidak mampu bertahan sampai sekarang. Teknologi biogas salah satunya. Banyak model biogas di Kabupaten Enrekang yang telah dilaksanakan. Namun tingkat keberhasilannya rendah dalam daya tahan teknologi. Banyak teknologi biogas yang rusak menyebabkan masyarakat peternak enggan menggunakan alat ini. Metode pelaksanaanya itu Feses dicampur dengan air, menggunakan perbandingan 1 : 1 diaduk hingga merata. Feses yang telah tercampur dengan air kemudian dimasukkan ke dalam digester selanjutnya didiamkan selama 10 – 20 hari dalam keadaan hampa udara (anerob). Pada kondisi inilah terjadi reaksi dan interaksi antara bakteri metanogen dan non-metanogen serta bahan yang diumpankan ke dalam digester sebagai input. Ini adalah proses phisio-kimia yang kompleks dengan proses biologis yang melibatkan berbagai faktor dan tahapan bentuk. Hasil kegiatan menunjukkan adanya perbedaan digester berbahan fiber dan digester berbahan beton. Selain berbeda kapasitas, reaktor pada digester beton lebih banyak menghasilkan gas. Gas dari digester beton tidak perlu ditampung, tapi langsung disambungkan ke kompor. Hasilnya digester beton dapat digunakan memasak sepanjang hari sedangkan digester fiber hanya mampu digunakan beberapa jam saja.