Articles

Effect of Spontaneous Delivery and Elective Caesarean Section on Number of Bifidobacterium Colony in Newborns Irwanto, Engga L.; Yusrawati, Yusrawati; Jurnalis, Yusri D.; Rasyid, Roslaily; Machmud, Rizanda
Indonesian Journal of Obstetrics and Gynecology Vol. 35. No 2. April 2011
Publisher : Indonesian Journal of Obstetrics and Gynecology

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AbstractObjective: To know the effect of vaginal delivery and elective caesarean section in total colony of bifidobacterium in newborn’s faeces.Method: All the research subject who has fulfilled the inclusion criteria, the newborn’s faeces taken on the 3rd to 4th day after delivery. One cc of faeces diluted into 9 cc thioglycolate in a sterile tube and sent to the Microbiology Laboratory of Hospital of Dr. M. Djamil Padang for the examination of colony of bifidobacterium. Data was processed and analized statistically.Result: The sample was taken from 41 research subject of vaginal delivery and 41 research subject of elective caesarean section. The average of total colony of bifidobacterium in newborn’s faeces with vaginal delivery is 23,588,220 CFU/gram and the average of total colony of bifidobacterium in newborn’s faeces with elective caesarean section is 4,151,829.3 CFU/gram.Conclusion: Total colony of bifidobacterium in newborn’s faeces with vaginal delivery is higher than elective caesarean section, and proved statistically significant (p < 0.05).[Indones J Obstet Gynecol 2011; 35-2: 49-52]Keywords: bifidobacterium, vaginal delivery, caesarean section
The status of probiotics supplementation during pregnancy Wibowo, Noroyono; Mose, Johanes C.; Karkata, Made K.; Purwaka, Bangun T.; Kristanto, Herman; Chalid, Maisuri T.; Yusrawati, Yusrawati; Sitepu, Makmur; Kaeng, Juneke J.; Bernolian, Nuswil; Prasmusinto, Damar; Irwinda, Rima
Medical Journal of Indonesia Vol 24, No 2 (2015): June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (514.372 KB) | DOI: 10.13181/mji.v24i2.1223

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Probiotics have been known for their use in medical field for quite a long time. Strong evidences are now available for the use of probiotics in clinical setting. One of the current issues on this topic is the use of probiotics in pregnancy. Recent studies showed that probiotics may be safe and beneficial for prenatal supplementation. In this review, we highlighted several proven use of probiotics supplementation in pregnant women. A few selected strains of probiotics showed promising outcome to prevent preterm labor and preeclampsia, and to reduce atopic eczema but not asthma and wheezing, in offspring of women who had prenatal probiotics supplementation. The mechanism of action responsible for this effect is closely related to the regulation of T cells, although the exact pathways are not defined yet.
Differences in Maternal Leptin Serum Levels between Normal Pregnancy and Preeclampsia Yusrawati, Yusrawati; Habibah, Ratna Lestari; Machmud, Rizanda
The Indonesian Biomedical Journal Vol 7, No 1 (2015)
Publisher : The Prodia Education and Research Institute (PERI)

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BACKGROUND: Maternal circulating leptin, placental leptin gene expression and protein levels are increased in preeclampsia as compared with those in normal pregnancy. Increased serum leptin levels in preeclampsia which correspond with increased gestational age can be used independently or with other parameters as a marker for the severity of preeclampsia. The advantages of this examination in identifying preeclampsia severity are its simplicity, fast result, low cost and applicability.METHODS: A cross-sectional study was conducted in delivery room, polyclinic of Dr. M. Djamil Hospital, and Biomedical Laboratories of Medical Faculty of Andalas University from December 2013 to April 2014. The samples were collected from 68 women with singleton pregnancy in their third trimester (>28 weeks) presenting to the polyclinic and the delivery room of Dr. M. Djamil hospital. Differences in maternal serum leptin between preeclampsia and normal pregnancy were determined using t-test and Wilcoxon test for data with and without normal distribution, respectively, where p<0.05 indicating a significant results.RESULTS: The mean maternal serum leptin levels in normal pregnancy and preeclampsia were 1588.7964 ± 8.01074 ng/mL and 1608.1725 ± 6.69579 ng/mL, respectively. Thus, there is a statistically significant difference in mean maternal serum leptin levels between the normal pregnancy and preeclampsia (p<0.05).CONCLUSION: There are significant differences in maternal serum leptin levels between women with normal pregnancy and preeclampsia.KEYWORDS: leptin, preeclampsia, pregnancy
Third trimester maternal 1,25-dihydroxyvitamin D and neonatal birth weight Yusrawati, Yusrawati; Idaman, Meldafia; Lipoeto, Nur Indrawati
Paediatrica Indonesiana Vol 57 No 2 (2017): March 2017
Publisher : Indonesian Pediatric Society

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AbstractBackground The main cause of neonatal mortality is low birth weight. Active form of vitamin D (1,25-dihydroxyvitamin D) increase the efficiency of calcium and phosphorous absorption in intestinal. Deficiency 1,25-dihydroxyvitamin D in pregnant woman was hipothesized relates with low birth weight in neonate.Objective To determine the relationship between maternal 1,25-dihydroxyvitamin D level and neonatal birth weight.Methods This was an observational study with cohort design to 47 women in the third trimester pregnancy. This study was cond  ucted on August to December 2014. Subjects were taken from Ibu dan Anak Hospital, Padang, West Sumatera. Maternal blood from antecubital vein was examined for 1,25-dihydroxyvitamin D concentration using enzyme-linked immunosorbent assay (ELISA). Neonatal birth weights were measured right after delivery.  Data were analyzed by Pearson’s correlation and linear regression tests.Results A positive correlation was found between maternal 1,25-dihydroxyvitamin D level and neonatal birth weight (R=0.910; R2=0.821; P=0.000). The 1,25-dihydroxyvitamin D level had an 82.1% contribution to the baby’s birth weight, while other factors not assessed in this study had less of an effect.Conclusion There was positive correlation between maternal 1,25-dihydroxyvitamin D levels in the third trimester of pregnancy and neonatal birth weight
Faktor Risiko dan Luaran Maternal Plasenta Akreta di RSUP Dr. M. Djamil Padang Qatrunnada, Annissa; Antonius, Puja Agung; Yusrawati, Yusrawati
Indonesian Journal of Obstetrics & Gynecology Science Volume 1 Nomor 2 September 2018
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

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AbstrakTujuan: Penelitian ini bertujuan untuk mengetahui frekuensi kejadian, hubungan faktor risiko, dan luaran maternal dengan plasenta akreta.Metode: Penelitian ini adalah analitik observasional dengan desain cross sectional. Penelitian dilakukan di bagian rekam medis RSUP Dr. M. Djamil Padang dari Januari 2016 sampai Desember 2017 dengan sampel penelitian berjumlah 84 orang yang terbagi dalam 2 kelompok, yaitu kelompok suspek plasenta akreta dan kelompok kontrol.Hasil: Hasil penelitian didapatkan sebanyak 64 orang (4,3%) terdiagnosa suspek plasenta akreta. Terdapat hubungan yang bermakna antara usia, paritas, riwayat seksio sesarea, dan plasenta previa (p<0,05) dengan plasenta akreta. Didapatkan riwayat sectio cesarea ≥ 2 kali merupakan faktor dominan pada plasenta akreta (OR 6,038, 95% CI 2,145−16,995). Terdapat hubungan yang bermakna antara lama rawat >7 hari, butuh transfusi darah, dan histerektomi (p<0,05) dengan plasenta akreta.Kesimpulan: Riwayat sectio cesarea, plasenta previa, usia, dan paritas merupakan faktor risiko plasenta akreta dengan morbiditas berupa lama rawat >7 hari, butuh transfusi darah, dan histerektomi.Kata kunci: Plasenta akreta,  seksio sesarea, plasenta previaAbstractObjective: This study aims to determine the frequency of occurrence, association of risk factors, and maternal outcomes with placenta accreta.  Method: This is an observational analytic with a cross-sectional design. This study was conducted in the medical record Dr. M. Djamil Padang General Hospital from January 2016 until December 2017 with total samples of the study were eighty four people and divided into 2 groups, suspected placenta accreta group and control group.Result: The result showed 64 people (4.3%) were diagnosed with suspect placenta accreta. There were significant association between age, parity, prior cesarean section, and placenta previa (p<0.05) with placenta accreta. The dominant factor in placenta accreta is ≥ 2 prior cesarean section (OR 6,038, 95% CI 2,145-16,995). There were significant association between length of stay more than 7 days, need blood transfusion, and hysterectomy (p<0,05) with placenta accreta.Conclusion: Prior cesarean section, placenta previa, maternal age, and parity are risk factors for placenta accreta with maternal morbidity such as length of hospital stay more than 7 days, requires blood transfusion, and hysterectomy.Key words: Placenta accreta, cesarean section, placenta previa 
Pengaruh Pemberian Tablet Zink dan Besi terhadap Kadar Hemoglobin dan Feritin pada Ibu Hamil Anemia Defisiensi Besi Wildayani, Desi; Yusrawati, Yusrawati; Ali, Hirowati
Jurnal Kesehatan Andalas Vol 7 (2018): Supplement 4
Publisher : Fakultas Kedokteran Universitas Andalas

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Anemia pada kehamilan merupakan salah satu masalah nasional karena pengaruhnya sangat besar terhadap kualitas sumber daya manusia. Oleh karena itu, anemia memerlukan perhatian serius dari semua pihak yang terkait dalam pelayanan kesehatan. Sebagian zink merupakan alat transpor transferin, yang juga merupakan alat transpor zat besi. Suplemen zink dianjurkan apabila ibu hamil mendapat suplemen besi. Tujuan penelitian ini adalah mengetahui pengaruh pemberian tablet zink dan besi terhadap kadar hemoglobin dan feritin pada ibu hamil anemia defisiensi besi. Jenis penelitian ini adalah quasi eksperiment dengan metode non randomized control group pre test and post test design. Penelitian dilakukan di Puskesmas Lubuk Buaya Padang dan Laboratorium Biomedik Universitas Andalas pada bulan Oktober 2017 – Maret 2018 terhadap 30 orang ibu hamil trimester II dan III, kadar Hb <11 g/dl dan ferritin <15 ng/ml yang diambil dengan cara consecutive sampling. Sampel dibagi menjadi 2 kelompok (intervensi dan kontrol). Kadar feritin diperiksa dengan ELISA dan kadar hemoglobin dilakukan dengan metode Hematology analyzer. Uji normalitas data dengan uji Saphiro wilk dan dilanjutkan dengan uji T berpasangan dan uji T tidak berpasangan. Hasil penelitian didapatkan ibu hamil yang diberikan tablet zink dan besi rata-rata selisih kadar hemoglobinnya lebih tinggi (1,07 g/dl) dibandingkan dengan ibu hamil yang mendapatkan tablet besi saja (0,81 g/dl), dengan nilai p = 0,190. Selisih kadar feritin serum lebih tinggi pada ibu hamil yang mendapatkan tablet besi saja (19,39 ng/ml) dibandingkan dengan ibu hamil yang mendapatkan tablet zink dan besi (14,64 ng/ml), dengan nilai p = 0,529. Kesimpulan penelitian ini adalah tidak terdapat pengaruh pemberian tablet zink dan besi terhadap kadar hemoglobin dan feritin pada ibu hamil anemia defisiensi besi.
Perbedaan Rerata Kadar Resistin dan TNF-Α Antara Wanita Hamil Yang Obesitas dengan yang Memiliki Berat Badan Normal Pada Preeklamsi Berat Awitan Lambat Suryanis, Ira; Decroli, Eva; Yusrawati, Yusrawati; Darwin, Eryati
Jurnal Kesehatan Andalas Vol 7, No 1 (2018)
Publisher : Fakultas Kedokteran Universitas Andalas

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Faktor maternal merupakan pencetus Preeklamsi Awitan Lambat (PEAL). Salah satu faktor maternal adalah resistin, TNF-α yang dihubungkan dengan inflamasi dan resistensi insulin.. Tujuan penelitian ini adalah mengetahui perbedaan rerata kadar Resistin dan TNF-α maternal antara wanita hamil obesitas dan berat badan normal pada Preeklamsi Berat Awitan Lambat. Desain penelitian ialah comparative cross sectional yang dilakukan di RSUP Dr. M Djamil dan Laboratorium Biomedik Fakultas Kedokteran Universitas Andalas Padang dari Februari 2016 sampai Januari 2017. Jumlah sampel sebanyak 40 yang dipilih secara consecutive sampling, yang dibagi menjadi 2 kelompok yaitu 20 responden obesitas dan 20 responden berat badan normal. Kadar Resistin danTNF-α diperiksa dengan metode ELISA, kemudian data dianalisis dengan uji mann-whitney. Hasil penelitian median kadar resistin pada kelompok obesitas adalah 7,760 (3,862 – 40,620) ng/ml dan median kelompok berat badan normal adalah 2,696 (0,0154 – 6,1070) ng/ml. Median kadar TNF-α pada kelompok obesitas adalah 169,719 (152,312 – 451,04) ng/ml dan median kelompok berat badan normal 131,077(75,724 – 150,920) ng/ml. Secara statistik dengan uji mannwhitney diperoleh nilai p<0,001. Simpulan studi ini ialah terdapat perbedaan bermakna antara kadar Resistin dan TNF-α pada obesitas dan berat badan normal.
Twin to Twin Transfusion Syndrom Yusrawati, Yusrawati; Effendy, Rika
Jurnal Kesehatan Andalas Vol 3, No 2 (2014)
Publisher : Fakultas Kedokteran Universitas Andalas

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AbstrakPeningkatan mortalitas pada kembar monokorion disebabkan oleh adanya anastomosis vaskuler pada plasenta yang menyebabkan Twin to Twin Transfussion syndrome.Berikut laporan kasus yang ditangani di RS. DR. M. Djamil Padang. Kasus 1: Seorang pasien usia 28 tahun dengan diagnosa MP3 gravid preterm 33-34 minggu dengan Twin To Twin Transfusion Syndrom, Dari pemeriksaan USG didapatkan kesan: Gemelli, gravid 33-34 minggu dengan TTTS. Pasien diterminasi secara SCTPP. Bayi pertama lahir perempuan, dengan: BB: 1400 grams, PB: 44 cm, A / S: 8/9, Bayi ke II: perempuan, BB: 1000 grams, PB: 38 cm, A / S: 6/7, Hb janin I: 16,9 g/dl dan Hb janin II : 11,3 g/dl. Kedua bayi dirawat di bagian perinatology. Bayi pertama bertahan hidup dengan beberapa kelainan kongenital yaitu VSD dan Hemangioma Orbita. Bayi kedua meninggal pada usia 7 hari dengan susp. Sepsis. Hingga saat ini, bayi ini masih kontrol rutin ke poliklinik RS. DR. M. Djamil Padang. Kasus 2: Seorang pasien usia 31 tahun dengan diagnosa MP5 parturient aterm kala II dengan gemelli. Pasien melahirkan spontan. Bayi pertama lahir perempuan dengan: BB: 3200 grams, PB: 48cm, A / S: 8/9, Bayi ke II perempuan : BB: 2100 grams, PB: 44 cm, A / S: 7/8. Kadar Hb bayi I : 17,6 g/dl dan bayi II: 14,1 g/dl. Plasenta lahir secara spontan lengkap 1 buah, berat 1150 gr, ukuran 20x19 x3 cm, panjang kedua tali pusat masing-masing 60 cm, insersi paracentralis,Monokhorion-Monoamnion. Kesan: TTTS.Kata kunci: twin to twin transfusion sindrom, ultrasonografi, monokorionAbstractIncreased mortality in monochorionic fetus caused by vascular anastomosis in the placenta that causes Twin to Twin Transfusion Syndromes (TTTS). Reporting two cases experienced and taken care in our hospital. Case1: a woman 28 years old was diagnosed with MP3 preterm pregnancy 33-34 weeks with Twin to Twin Transfusion Syndromes.Ultrasound impression: Gemelli gravid 33-34 weeks with TTTS. The patient was terminated by SCTPP. The first baby was female, born with: BW: 1400 grams, BL: 44 cm, A / S: 8/9, the second baby: female, BW: 1000 grams, BL: 38 cm, A / S: 6/7 the first baby Hemoglobin was 16,9 g/dl and the second baby was 11,3 g/dl. The babies were treated in Perinatology, the first baby survive with some congenital abnormalities such as VSD and hemangioma in the orbita. The second baby died at the age of 7 days with suspected sepsis. To date the baby still has a routine medical checkup to RS. DR. M. Djamil Padang. Case2: a woman 31 years old with diagnose MP5 term parturient in second stage of labour with, gemelli. The babies were born spontaneously. The first baby: BW: 3200 gr, BL: 48 cm, A/S: 8/9. The second baby: BW: 2100 gr, BL: 44 cm, A/S: 7/8. Hemoglobin Concentration of the first baby: 17,6 g/dl and the second baby : 11,4 g/dl. Placenta was born monochorion, diamnion.Keywords:twin to twin transfusion syndrome, ultrasonography, monochorion
PERBANDINGAN KUALITAS SPERMATOZOA PADA ANALISIS SEMEN PRIA DARI PASANGAN INFERTIL DENGAN RIWAYAT MEROKOK DAN TIDAK MEROKOK Ridhoila, Indah; Yusrawati, Yusrawati; Amir, Arni
Jurnal Kesehatan Andalas Vol 6, No 2 (2017)
Publisher : Fakultas Kedokteran Universitas Andalas

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Infertilitas merupakan masalah pada sistem reproduksi yang dapat mengenai pria ataupun wanita dengan jumlah 48,5 juta pasangan di dunia. Infertilitas pada pria sering disebabkan oleh kelainan pada tingkat pre testikular, testikular, dan post testikular. Salah satu faktor resiko infertilitas adalah merokok, zat toksin yang terdapat pada rokok dapat menyebabkan peningkatan Reactive Oxygen Species (ROS) yang nantinya bisa menyebabkan stress oksidatif jaringan sehingga mengganggu kualitas spermatozoa. Tujuan penelitian ini adalah membandingkan kualitas spermatozoa pada pria dari pasangan infertil dengan riwayat merokok dan tidak merokok. Penelitian cross sectional ini menggunakan data rekam medis analisa semen di Klinik Spesialis Obstetri dan Ginekologi dan RSU Citra BMC Padang yang dilakukan dari Desember 2016 sampai April 2017. Didapatkan 64 sampel yang memenuhi kriteria inklusi. Perbandingan kualitas spermatozoa pria ini dianalisa dengan chi-square dan Mann-whitney dengan (p<0,05). Hasil penelitian didapatkan kualitas spermatozoa (morfologi, motilitas, konsentrasi) tidak bermakna (p >0,05). Simpulan penelitian ini adalah tidak terdapat perbedaan bermakna kualitas spermatozoa pria dari pasangan infertil dengan riwayat merokok dan tidak merokok.
Perbedaan Rerata Kadar Profil Lipid pada Preeklampsia dengan Kehamilan Normal pada Etnik Minangkabau Evelina Siringoringo, Helen; Yusrawati, Yusrawati; Chundrayetti, Eva
Jurnal Kesehatan Andalas Vol 5, No 1 (2016)
Publisher : Fakultas Kedokteran Universitas Andalas

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AbstrakPreeklampsia-eklampsia sampai saat ini masih merupakan disease of theory. Kelainan yang terjadi pada penyakit ini adalah disfungsi endotel yang dapat disebabkan oleh perubahan kadar profil lipid. Tujuan penelitian ini adalah mengetahui perbedaan rerata kadar profil lipid pada preeklampsia dengan kehamilan normal pada etnik Minangkabau. Penelitian observasional dengan rancangan cross sectional ini dilakukan di RSUP dr. M. Djamil Padang, RS Reksodiwiryo Padang dan UPTD Laboratorium Kesehatan Daerah Sumatera Barat. Subjek terdiri dari 2 kelompok yang diambil secara consecutive sampling dengan jumlah masing-masing 27 orang. Pemeriksaan profil lipid dilakukan dengan metode kalorimetri. Analisis data dilakukan secara uji statistik independent t-test. Hasil penelitian diperoleh rerata kadar total kolesterol pada kelompok preeklampsia dan kehamilan normal adalah 270,19+68,955 mg/dL dan 247,56+44,415 mg/dL dengan nilai p=0,158, rerata kadar trigliserida pada kelompok preeklampsia dan kehamilan normal adalah 296,07±157,993 mg/dL dan 272,89±84,608 mg/dL dengan nilai p=0,504, rerata kadar HDL pada kelompok preeklampsia dan kehamilan normal adalah 51,93±19,882 mg/dL dan 63,33±11,222 mg/dL dengan nilai p=0,012, rerata kadar LDL pada kelompok preeklampsia dan kehamilan normal adalah 159±52,038 mg/dL dan 129,67±38,692 mg/dL dengan nilai p=0,023, rasio perbandingan LDL/HDL pada kelompok preeklampsia dan kehamilan normal adalah 3,86 dan 2,04. Dari hasil penelitian dapat disimpulkan pada kedua kelompok tidak ada perbedaan kadar kolesterol total dan trigliserida, tetapi ada perbedaan kadar HDL dan LDL , rasio perbandingan LDL/HDL lebih tinggi pada preeklampsia daripada kehamilan normal.Kata kunci: preeklampsia, total kolesterol, trigliserida, HDL, LDL, etnik Minangkabau AbstractPreeclampsia-eklampsia still being a disease of theory. One of abnormality accured in preeclampsia is endothelial disfunction that is caused by changes in lipid profile. The objective of this study was to find out the difference of lipid profile mean level in preeclampsia and normal pregnancy at Minangkabau Ethnic. This was an observational study with cross-sectional design at  dr. M.djamil Padang Hospital, dr Reksodiwiryo Hospital and UPTD regional health laboratory of West Sumatera. The subjects consist of two groups, choosen by consecutiteve sampling. Each group consist of 27 subjects. Lipid profile was examined by using independent calorimetric methode. The data analyzed statistically by independent t-test. The result of this study showed mean level of total cholesterol in preeclamsia and normal pregnancy were 270.19±68.955 mg/dL and 247.56±44.415 mg/dL with p-value 0.158. The mean levels of triglyceride in preeclampsia and normal pregnancy were 296.07±157.993 and 272.89±44.415 mg/dL with p-value 0.504. The mean level of HDL in preeclampsia and normal pregnancy were 51.93±19.882 mg/dL and 63.33 mg/dL p-value 0.012. The mean level of LDL in two groups were 159±52.038 mg/dL and 129.67±38.692 mg/dL with p-value 0.023 and the mean levels of LDL/HDL ratio were 3.86±3,09 mg/dLin  preeclampsia and 2,08±0,64 in normal pregnancy. It can be concluded that there is no significant difference in total cholesterol and triglyseride between preeclampsia and normal in HDL and LDL and there is significant difference in LDL/HDL ratio between preeclampsia and normal pregnancy at Minangkabau Ethnic.Keywords: preeclampsia, total cholesterol, triglyceride, HDL, LDL, Minangkabau Ethnic