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Journal : Journal Of The Indonesian Medical Association (JInMA)

Cajal Interstitial Cells: The Pacemaker that Play a Role in Gastrointestinal Tract Malignancy Suryani, Des; Yuliana, Ida; Pawitan, Jeanne Adiwinata
JOURNAL OF THE INDONESIAN MEDICAL ASSOCIATION Majalah Kedokteran Indonesia Vol 63, No 9 (2013): Journal of the Indonesian Medical Association Majalah Kedokteran Indonesia
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA

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Abstract

Introduction: Interstitial cell of cajal (ICC) has a fusiform-shaped cell body, an oval nucleus, and a few cytoplasm. It has two to five primary cytoplasmic branches that again branch into secondary and tertiary branches so that the cell looks like a star (stellate cells) and was suspected to be a neuron. The cell has few contractile elements, many mitochondria and endoplasmic reticulum, and exists between nerve endings and smooth muscle cells. It can be found in the gastrointestinal tract, and outside the gastrointestinal tract, such as in the kidneys, various organs of the reproductive system, pancreas and blood vessels (portal vein). The main function of ICC is as a pacemaker. Malignancy of ICC causes gastrointestinal stromal tumor (GIST) that need to be distinguished from other tumors due to the different management. This review discusses the histophysiology of ICC that has a great importance in diagnosing GIST, especially in the pancreas. ICC derived tumors can be diagnosed by using ICC markers c-Kit and ANO 1 (more specific). J Indon Med Assoc. 2013;63:373-7.