Yana M. Syah
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RESVERATROL OLIGOMERS FROM DIPTEROCARPUS HASSELTII: CYTOTOXIC EFFECT AND CHEMOTAXONOMIC SIGNIFICANCE Muhtadi Muhtadi; Euis H. Hakim; Yana M. Syah; Lia D. Juliawaty; Jalifah Latip
Jurnal Ilmiah Farmasi Vol 5, No 1 (2008)
Publisher : Jurnal Ilmiah Farmasi

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Abstract

ABSTRACTTwo resveratrol tetramers, (-)-vaticanol B and (-)-hopeaphenol, were isolated from acetoneextract of the tree bark of Dipterocarpus hasseltii (Dipterocarpaceae), together with the knownresveratrol trimer, (-)-α-viniferin. The structures of these compounds were established based onspectroscopic evidence, UV, IR,1H-NMR,13C-NMR and determined by comparison with thestandard compounds. The cytotoxic activities of these compounds were evaluated against murineleukaemia P-388 cells. The IC50 values of all compounds were 42.2, 5.0 and 17.5 μg/ml,respectively. In addition, chemotaxonomic significance relationship between Dipterocarpus, Shoreaand Vatica will also be briefly discussed.Keywords: Chemotaxonomy, Cytotoxic, Dipterocarpaceae, D. hasseltii,Resveratroltetramer