Noor Wijayahadi
Dosen Farmakologi Fakultas Kedokteran, Universitas Diponegoro

Published : 46 Documents
Articles

Ekstrak Bawang Putih (Allium sativum) dan Ekspresi Insulin serta Derajat Insulitis Pankreas Tikus Sprague-Dawley yang Diinduksi Streptozotocin Dewi, Meira; Wijaya, Indra; Wijayahadi, Noor
MEDIA MEDIKA INDONESIANA 2011:MMI Volume 45 Issue 2 Year 2011
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ABSTRACTAllium sativum, insulin expression and insulitis degree of pancreas Sprague-Dawley rat induced by streptozotocinBackground: The organic-sulphur content in Allium sativum has been scientifically proven to be a potent insulin-mimetic, antioxidant, and anti-inflammation agent by inhibiting the activity of NF-κβ. This research is aimed at finding out the effect of Allium sativum extract towards insulitis level and insulin expression in pancreas of Sprague-Dawley male rats.Method: This research used a randomized post test only controlled group design. There were 28 rats, two were randomly selected for the initial blood glucose test prior to treatment, two were selected on the tenth day after streptozotocin induction to ensure that all rats were in hyperglycaemia condition, and the remains as many as 24 rats were grouped into four groups: three treatmentgroups were administered with Allium sativum in levelled doses of 0.1, 0.25, 0.5 grams/kgBW/day for 14 days, and one group were act as control negative. Kruskall Wallis test continued with Mann Whitney test were used, with significance level of p<0.05.Results: The insulitis level and insulin expression of rats’ pancreas in the three treatment groups showed significant difference compared with the group without treatment showing dose-dependent result. However, it was not able to completely restore the damage pancreas.Conclusion: Allium sativum extract may play important role in restoring damage pancreas.Keywords: Allium sativum, streptozotocin, insulin expression, level of insulitisABSTRAKLatar belakang: Kandungan organosulfur pada Allium sativum secara ilmiah memiliki berbagai potensi sebagai agen insulinomimetic, antioksidan dan antiinflamasi dengan menghambat aktivitas NF-κß. Penelitian ini bertujuan untuk melihat pengaruh pemberian ekstrak Allium sativum terhadap derajat insulitis dan ekspresi insulin pankreas tikus Sprague-Dawley jantan.Metode: Penelitian ini menggunakan desain randomized post test only controlled group. Hewan coba sebanyak 28 ekor tikus, dua ekor tikus diambil acak sebelum perlakuan untuk diperiksa gula darah awal, dua ekor setelah hari ke sepuluh induksi streptozotocin untuk memastikan tikus sudah dalam keadaan hiperglikemia dan sisanya dua puluh empat ekor tikus, dibagi dalam empat kelompok: tiga kelompok perlakuan diberi ekstrak Allium sativum dosis bertingkat 0,1, 0,25, 0,50 g/kgBB/hari selama 14 hari, dan satu kelompok sebagai kontrol negatif. Digunakan uji non parametrik Kruskal Wallis dilanjutkan Mann Whitney dengan taraf kemaknaan p<0,05.Hasil: Derajat insulitis dan ekspresi insulin pankreas tikus pada ketiga kelompok perlakuan menunjukkan perbedaan bermakna dibandingkan dengan kelompok yang tidak mendapat perlakuan dan bersifat dose – dependent, namun belum dapat mengembalikan pulau Langerhan kembali ke keadaan normal.Simpulan: Ekstrak Allium sativum berpeluang memperbaiki pankreas yang rusak.
The Effect of Nigella sativa L Oil on Wistar Rat’s Spermatozoa Quality Exposed by Cigarrete Smoke Musfiroh, Mujahidatul; Muslim, Rifki; Wijayahadi, Noor
Journal of the Indonesian Medical Association Vol. 62 No. 5 May 2012
Publisher : Journal of the Indonesian Medical Association

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Introduction: Exposure to cigarette smoke increase the production of Reactive Oxygen Species(ROS), one of the mediators causing infertility. Nigella sativa L may act as an antioxidant in aneffort to improve infertility.Methods: Experimental study were conducted on 24 male wistar rats exposed to cigarette smoke for 21 days and were randomized into 4 groups: control group and the group treated with black cumin oil administrated orally at a dose of 0.1 ml, 0.2 ml, and 0.3 ml. Analyses were performed using Kruskal-Wallis and Mann Whitney statistical test.Results: Delivery of Nigella sativa L oil orally at a dose of 0.1 ml, 0.2 ml, 0.3 ml show improvement on viability (p=0.004), motility (p=0.049), the rate of movement of the spermatozoa (p = 0.055), and abnormalities in sperm morphology (p=0.039).Conclusion: Viability, motility, the rate of movement, and abnormal morphology of spermatozoain wistar rats exposed to cigarette smoke by the provision of black cumin oil (Nigella sativa L) is better compared to the control group. J Indon Med Assoc. 2012;62:178-82.Keywords: Oil Nigella sativa L, spermatogenesis, exposure to cigarette smoke
FAKTOR PENGARUH KEPATUHAN MAHASISWA DAN KARYAWAN TERHADAP PERATURAN KAWASAN TANPA ROKOK DI LINGKUNGAN KAMPUS FAKULTAS KEDOKTERAN UNIVERSITAS DIPONEGORO Puswitasari, Amalia; Santosa, Santosa; Wijayahadi, Noor
MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
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Background : According to WHO data, more than one billion people worldwide use of cigarettes and caused the deaths of more than 5 million people each year. It is estimated the majority of deaths occur in people who live in countries with low and middle income, including Indonesia. use of cigarettes is one of the biggest risk factor in disease is not contagious, because the policy was implemented without smoking area has been identified as a primary intervention strategy to control the disease which is not contagious, but in reality many people on a daily behavior do not indicate compliance with these regulations.Aim : To know student and staff participation in No Smoking Areas comply with the regulations in the Diponegoro University School of Medicine campus environment Semarang.Methods : The study was observational analytic study with cross-sectional study. Samples were obtained by taking the respondents randomly (simple random sampling) until the time the study ended in July 2012. Primary data in the form of descriptive data were presented in tabular form with a pictures or diagrams. Data were analyzed using chi-square test (χ2) Results There was a significant association between the background of smoking behavior (p = 0.01) and knowledge of no smoking areas regulation (p = 0.007) to the level of compliance, while knowledge of the dangers of cigarettes content showed no significant results (p = 0.6), then the influence of the environment provided risk 1.6 (1.1 to 2.2) times the level of compliance, not know the dangers of cigarettes content provided risk 1.3 (0.5 to 3.4) times, and not know the no smoking areas regulation provided risk 1.5 (1.1 to 2.0) times.Conclusion : The background of smoking behavior and knowledge of no smoking areas regulation affect the level of compliance while knowledge of the dangers of cigarettes content has no effect.Keywords : smoking, no smoking areas, behavior, danger, content, compliance
Analisis Fungsi Fagositosis Sel Leukosit Penderita Sinusitis Kronik pada Pengobatan Gurah Andiyoga, Fathurrahman; Wijayahadi, Noor
MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
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Latar Belakang: Gurah merupakan pengobatan tradisional asli dari Indonesia dengan menggunakan tanaman dan ramuan asli Indonesia. Tujuan dari gurah adalah membersihkan sistem respirasi. Saat ini gurah mulai digunakan untuk terapi sinusitis kronik. Penelitian tentang hubungan antara transport mukosiliar rhinitis kronik dengan metode gurah sudah dilakukan, namun belum ada penelitian yang mengkaitkan hubungan antara aktifitas fagositosis sinusitis kronik dengan metode gurah.Tujuan: Menganalisis perubahan fungsi fagositosis sel leukosit penderita sinusitis kronik pada pengobatan gurah dengan akar Senggugu (Clerodendron serratum Spreng) yang telah distandardisiasi.Metode: Penelitian dilakukan menggunakan studi observasional dengan rancangan pre and post controlled group design terhadap 66 pasien sinusitis kronik di Unit-Unit Teknis Pelayanan SP3T Jawa Tengah dan RSUP Dr Kariadi. Pasien yang dilakukan gurah merupakan kelompok perlakuan dan pasien yang tidak dilakukan gurah merupakan kelompok kontrol. Seluruh sampel diambil data klinisnya dan diperiksa aktifitas fagositosisnya.Hasil: Aktifitas fagositosis rata-rata pasien sebelum digurah adalah 100,17±19,0%. Aktifitas fagositosis rata-rata pasien pada 1 minggu setelah digurah adalah 98,43±17,7%. Tidak terdapat perbedaan bermakna (p=0,743) antara aktifitas fagositosis sebelum dan 1 minggu setelah dilakukan gurah. Terdapat perbedaan bermakna (p=0,006) antara aktifitas fagositosis kelompok perlakuan dan kelompok kontrol pada satu minggu setelah pemeriksaan pertama. Aktifitas fagositosis kelompok perlakuan relatif tetap dengan penurunan tidak bermakna, (p=0,743) sedangkan pada kelompok kontrol mengalami penurunan aktifitas fagositosis bermakna (p=0,001).Kesimpulan: Aktifitas fagositosis pada pasien sinusitis kronik kelompok perlakuan gurah lebih baik daripada kelompok kontrol pada satu minggu setelah gurah..Kata kunci: gurah, aktifitas fagositosis, metode kemiluminesen
PERBANDINGAN KEPUASAN ANTARA PASIEN ASKES DAN PASIEN JAMKESMAS DI POLIKLINIK PENYAKIT DALAM RSUP DR.KARIADI SEMARANG Fatima, Desta; Santosa, Santosa; Wijayahadi, Noor
MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
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Background: Health is the right and investments, and all citizens are entitled to health, including the poor. It’s needed a system that regulates the implementation of the effort to fulfill the right of citizens to remain healthy, with an emphasis on health services for the community. Health insurance (Askes) is a type of financial services is very complex involving the three elements that can’t be separated the participant, the provider and insurance entities . Jamkesmas is a free healthcare program for the poor which in the previous year (in 2005) was called by the Health Insurance for Poor People, then in 2008 and later renamed with Jamkesmas. Askes in general used by the middle class and above, while Jamkesmas generally used by lower middle class people, because of differences in this social status, it is concerned about the services provided by health care providers will be different in the two groups then further affect the level of patient satisfaction.Aim: To know whether there were differences in patient satisfaction between Askes patients and Jamkesmas patients in the internal medicine clinic Dr.Kariadi Hospital Semarang.Methods: The study was observational analytic study with cross-sectional study. Samples obtained by taking the respondents were consecutive sampling until the end of the study period from May to July 2012. Primary data in the form of descriptive were presented in tabular form with pictures or diagrams. Datas were analyzed using chi-square test (χ2).Results: The interpretation datas of each class were test with chi-square test (χ2). It was showed non-significant p value (p = 0.054).Conclusion: There were no significant differences in patient satisfaction between patients who had Askes and patients who had Jamkesmas in the internal medicine clinic of Dr. Kariadi Hospital Semarang.Keyword: satisfaction, internal medicine clinic, Askes patients, Jamkesmas patients 
ANALISIS PERUBAHAN WAKTU TRANSPORTASI MUKOSILIAR HIDUNG PENDERITA SINUSITIS KRONIS PADA PENGOBATAN GURAH SURYADI, SUPRI; Wijayahadi, Noor; Sobirin, Mochamad Ali
MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
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Gurah adalah pengobatan tradisional yang banyak digunakan oleh masyarakatindonesia. Cara pengobatan gurah dengan memasukan ekstrak akar Senggugu kedalam lubang hidungdengan tujuan mengeluarkan kotoran dan lender yang ada dihidung dan rongga-rongga sekitarnya. Tujuan penggunaan gurah untuk berobatkarena penyakit/gangguan saluran nafas, hidung tersumbat, adapula agar suaramenjadi jernih dan lebih nyaring.
ANALISIS PENGARUH GURAH PADA PENDERITA SINUSITIS KRONIK TERHADAP ANGKA KEKAMBUHAN Abidin, Ali Zaenal; Wijayahadi, Noor
MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
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Background: Gurah is one of many traditional therapy to treat chronic sinusitis. Exacerbation could happened in chronic sinusitis patient, which can make the simptoms became worsen and decrease the quality of life of the patient. In this study senggugu root extract is used as gurah ingredient which contains tanin that according to previous studies serve as an antiseptic agents.Aim: This study aim was to know the different of the exarcebation rate between gurah chronic sinusitis patient and non gurah chronic sinusitis patient.Methode: The design of the study was observational with pre and post controlled group. Sample of this study were 66 patients of chronic sinusitis patients in the Kariadi Hospital Semarang that has been divided randomly in two group, control group and treatment group. Gurah treatments were given to the treatment group. Questionnares were given to both group to value the exacerbation rate. Patients were being observed in 3 months. Analysis of the data was processed by a computer program with difference test with 2x2 tabels and using fisher-exact analysis. S The significance levels were accepted if p < 0,05.Result: In the first month there weren’t any exarcebation in both control group and treatment group. The study continues to the third month. In the control group there were 5 patients that had exarcerbation. In treatment group there weren’t any exarcebation until the third month. Difference test was applied with 2x2 tabels and using chi-square analysis. There was 2 cell with expected count < 5,0 so it had to used altenative fisher-exact analysis. Fisher-exact analysis found significance different(p<0,05) between control group and treatment group at 0,03.Conclusion: There was significant decrease of exacerbation rate from gurah chronic sinusitis patient than non gurah chronic sinusitis patient.Key Word: gurah, chronic sinusitis, exacerbation
Analisis Kelengkapan Fasilitas Unit gawat Darurat Rumah Sakit Umum Pusat Dokter Kariadi Semarang Nurfadli, Nurfadli; Santoso, Santoso; Wijayahadi, Noor
MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
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Latar belakang : Setiap orang berhak memperoleh pelayanan kesehatan dari fasilitas pelayanan kesehatan agar dapat mewujudkan derajat kesehatan setinggitingginya. Sebuah rumah sakit harus mempunyai fasilitas pelayanan kesehatan yang memuaskan agar dalam pelaksanaannya tidak terjadi konflik antara pasien dan tenaga kesehatan. Tidak terkecuali pada bidang kegawatdaruratan medis dimana fasilitas kesehatan yang ada harus memenuhi standar mutu, keamanan dan kelayakan sesuai dengan ketentuan perundang-undangan.Tujuan : Menganalisis kelengkapan fasilitas pelayanan kesehatan dan alat-alat kesehatan di Unit Gawat Darurat Rumah Sakit Umum Pusat Dokter Kariadi SemarangMetode : Penelitian ini merupakan penelitian observasi dengan menggunakan metode checklist surveilans. Sampel adalah seluruh fasilitas pelayanan kesehatan dan alat-alat kesehatan serta obat-obatan termasuk di dalamnya dilakukanpendataan secara langsung lalu diolah menggunakan statistik deskriptif dan ditampilkan dalam bentuk tabel dan diagram.Hasil : Pada penelitian terhadap fasilitas pelayanan kesehatan didapatkan hasil 92,5% fasilitas pelayanan sudah tersedia di Unit Gawat Darurat RSUP Dr. Kariadi Semarang sedangkan 7,5% masih belum tersedia di UGD tersebut. Pada penelitian terhadap seluruh peralatan di UGD RSUP Dr. Kariadi Semarang didapatkan hasil sebanyak 82 buah atau 81,2% peralatan telah memenuhi syarat lengkap dan layak sedangkan terdapat 2 buah atau 2% peralatan yang lengkap tetapi tidak layak serta terdapat 17 buah atau 16,8% peralatan yang masih belum lengkap. Pada penelitan terhadap obat-obatan di UGD RSUP Dr. Kariadi Semarang didapatkan hasil sebanyak 44 sampel (97,8%) telah memenuhi syarat lengkap dan layak sedangkan terdapat 1 sampel (2,2%) yang masih belum lengkap.Kesimpulan : Fasilitas pelayanan kesehatan di RSUP Dr. Kariadi Semarang sudah sepenuhnya sesuai dengan standar pelayanan unit gawat darurat tetapi terdapat beberapa fasilitas masih perlu dilengkapi dan dilakukan perbaikan sedangkan obat-obatan yang tersedia sudah memenuhi syarat kelengkapan dan kelayakan.
Perbandingan Pelayanan Kesehatan pada Pasien Kelas 1 dengan VIP di Pusat Pelayanan Jantung dan Pembuluh Darah RSUP dr Kariadi Semarang. Ardiana, Desy Indira; Santosa, Santosa; Wijayahadi, Noor
MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
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Background : Hospital is a unit that has a regular organization, where prevention and cure of disease, health improvement and rehabilitation patients in a multidisciplinary done by various groups of skilled and educated professionals, used the infrastructure and physical facilities. Hospitalization room in Dr. Kariadi Hospital have some form class, they are third class, second class, first class and Very Important Person (VIP class. First class and VIP class services should be, in accordance with the Standard Minimum (SPM), same although with some different facilities. But the reality may be difference.Aim : To know whether the health service given to the patient in the hospitalization room in the Heart Service Unit of Dr. Kariadi Hospital was same between VIP class and first class.Method : This was an observational analytic study with cross-sectional study. The samples were obtained by taking respondents with consecutive sampling method until the end of the research (from May to July 2012). The gathered descriptive primary data were presented in the table form with images and diagrams. The data were analyzed using Fisher exact test.Results : The interpretation data of each class were analyzed using Fisher exact test but the result was not significant (p=0.49).Conclusion : There was no meaningful difference in the provided services between VIP class and first class in the Heart Service Unit of Dr. Kariadi Hospital Semarang.Keyword : service, hospitalization room, VIP class, first class, Dr. Kariadi Hospital
Analisis Perubahan Jumlah dan Jenis Sel PMN Penderita Sinusitis Kronik Pada Pengobatan Gurah Putra, Najih Rama Eka; Wijayahadi, Noor
MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
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Latar belakang: Gurah merupakan salah satu pengobatan tradisional untuk mengobati penyakit sinusitis kronis. Sinusitis yang disebabkan oleh infeksi bakteri atau virus, peran leukosit polymorphonuclear (PMN) dalam proses fagositosissangat penting. Pada penelitian ini ekstrak akar Senggugu digunakan sebagai ramuan gurah mengandung flavonoid dan sitosterol yang menurut penelitian terdahulu berfungsi sebagai antiinflamasi.Tujuan: Menganalisis perubahan jumlah dan jenis sel PMN penderita sinusitis kronik pada pengobatan gurah dengan akar Senggugu (Clerodendron serratum spreng) yang telah distandardisasi.Metode: Penelitian ini adalah penelitian observasi dengan rancangan pre and post controlled group design. Sampel penelitian ini adalah pasien sinusitis kronis di RSUP Dr Kariadi Semarang sebanyak 66 pasien dibagi dalam dua kelompoksecara acak yaitu kelompok kontrol dan kelompok perlakuan. Kelompok perlakuan diberikan pengobatan gurah. Analisis data diolah dengan SPSS 17.0. Uji tidak berpasangan untuk membandingkan kelompok kontrol dan perlakuan danuji t berpasangan untuk membandingkan sebelum dan sesudah digurah. Taraf signifikansi diterima bila p<0,05.Hasil: jumlah dan jenis rata-rata sel PMN pada pasien sebelum gurah adalah neutofil 65±5,1%, eosinofil 2,24±2,0%, dan basofil 0,36±0,5%. Jumlah dan jenis rata-rata sel PMN pada pasien setelah digurah adalah neutrofil 63±3,1%, eosinofil 2,15±2,0%, dan basofil 0,42±0,5%. Uji t tidak berpasangan menghasilkan perbedaan rerata bermakna (p<0,05) antara kelompok kontrol dan perlakuan sebesar 0,001 pada skor selisih neutrofil dan 0,041 pada skor selisih eosinofil. Meskipun didapatkan hasil perbedaan rerata yang tidak bermakna (p>0,05) pada skor selisih basofil yaitu sebesar 0,973. Uji t berpasangan menghasilkan perbedaan bermakna (p<0,05) antara kelompok sebelum dan sesudah digurah sebesar 0,004 pada skor neutrofil. Sedangkan untuk eosinofil dan basofil menghasilkan perbedaan rerata yang tidak bermakna (p>0,05), yaitu sebesar 0,366 pada skor eosinofil dan 0,414 pada skor basofil.Kesimpulan: Terdapat penurunan jumlah neutrofil dan eosinofil yang bermakna pada pasien sinusitis kronik yang mendapatkan pengobatan gurah dibanding yang tidak digurah. Jumah sel PMN pada penderita sinusitis kronik yang digurah lebih baik daripada yang tidak digurahKata kunci: gurah, sinusitis kronik, jumlah dan jenis sel PMN
Co-Authors Agus Priyatno, Agus Ali Zaenal Abidin Amalia Puswitasari Andika Eka Herlina, Andika Eka Andrew Johan Arfan, Pandhycha Veryza Pratama Argo Pandu Widigdo Bambang Witjahjo Desta Fatima Desy Indira Ardiana Devi Ninditya K., Devi Dwi Hadi Setya Palupi Edwin Tohaga, Edwin Elvi Suryati, Elvi Farida, Candra Fathurrahman Andiyoga Fatihatul Firdaus Munita, Fatihatul Firdaus Fiqih Kartika Murti, Fiqih Kartika Fuadi Fuadi Hartantyo Hartantyo, Hartantyo Hizkia Christian Willianto, Hizkia Christian I Made Prasetya Wardana, I Made Prasetya Ika Pawitra Miranti Indra Wijaya Iva-Yuana Iva-Yuana, Iva-Yuana Kamilah Budhi Kamilah Budhi R, Kamilah Budhi Kamilah Budhi Rahardjani, Kamilah Budhi Karlowee, Vega Ken Shinta, Ken Khanis, Abdul Kusdalinah Kusdalinah Kusmadewi Eka Damayanti Meira Dewi Mochamad Ali Sobirin Muhammad Sholeh Kosim, Muhammad Sholeh Mujahidatul Musfiroh Multazam, Rachmatu Bill Najih Rama Eka Putra Niken Puruhita Nofrian, Rifki Adhi NOVI ANGGRIYANI, NOVI Nurfadli Nurfadli Permatasari, Rizkia Nada Suci Putri Sekar Wiyati Putri, Rahmi Isma Asmara Ragil Parasmadhan, Ragil Ramadhan, Muhammad Fa'iz Ratna Damma Purnawati Rifki Agung, Rifki Rifki Muslim Rina Pratiwi Riska Sarah Dewi Meitina Pasha Rudy Handoyo, Rudy Santosa Santosa SANTOSO SANTOSO Sarah Dyaanggari Akip, Sarah Dyaanggari Silva Dwinta Junnisa, Silva Dwinta Siti Amarwati SUPRI SURYADI Tinjung Jatiningrum, Tinjung Tjahjono Tjahjono Tjipta Bahtera, Tjipta Tun Paksi Sareharto Wardani, Lisa Riana Yuda Nabella Prameswari