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Journal : Dental Journal (Majalah Kedokteran Gigi)

Effect of oxygen hyperbaric therapy on malondialdehyde levels in saliva of periodontitis patients with type 2 diabetes mellitus Mulawarmanti, Dian; Widyastuti, Widyastuti
Dental Journal (Majalah Kedokteran Gigi) Vol 41, No 4 (2008): (December 2008)
Publisher : Faculty of Dental Medicine, Universitas Airlangga

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Abstract

Background: Lipid peroxidation (LPO) has implication in pathogenesis of several pathological disorders including periodontitis. Malondialdehyde (MDA) is end products of upid peroxidation. Hyperbaric Oxygen Therapy (HBOT) involves the administration of 100% oxygen under atmosphere pressure and has been used as an adjuvant therapy, while saliva is a diagnostic tool for many oral and systemic diseases. Purpose: The aim of this study was to examine the effect of HBOT on malondialdehyde in saliva to measure lipid peroxidation in periodontitis patients with type 2 Diabetes Mellitus (DM). Methods: Eight regulated type 2 DM subjects were compared to ten unregulated periodontitis patients type 2 DM (n = 18). Pre HBOT and after 10 days HBOT with 2.4 ATA dose, unstimulated whole saliva samples from study subjects were collected, centrifuged at 3000 g for 15 minutes and were then stored at −80° C until analyzed. The MDA level was determined with 2-thiobarbituric acid by a colorimetric method at 532 nm. Results: Data showed that regulated type 2 DM had lower level of MDA (3.08 ± 0.62 ug/mol) compared with unregulated periodontally- type 2 DM subjects (5.88 ± 1.04 ug/mol) (p>0.05). MDA levels were significantly lower after HBOT in regulated DM (2.30 ± 0.46 ug/mol) compared with unregulated periodontally type 2 DM (4.09 ± 0.77ug/mol) (p < 0.05). The regulated DM subjects and post HBOT showed MDA levels lower than the periodontally-unregulated group significantly. Conclusion: The saliva of periodontitis patients with unregulated type 2 DM showed more lipid peroxidation than regulated DM type 2. HBOT decreased MDA levels in regulated and unregulated type 2 DM with periodontitis.
Co-Authors ABDUL GAFUR Adang Hardi Gunawan Afif, Muhammad Nur Agung Cahyono Agung Putra Wijaya, Agung Putra Agus Sugiarto Andini, Yuri Tri Aprilina, Ulfah Arnelis Djalil Asih Purnami Widiastuti Asri, Peggy Nurida Bidari, Masgusti Dinda Caswita Caswita Cecep Taufik Rustendi Dharma Himawan, Muhammad Agung Dian Mulawarmanti, Dian Diba, Shofura Farah Dwi Kurniawati, Dwi Dwi Laila Sulistiowati, Dwi Laila Elin Erlina Sasanti Eni Indriani Eni Kartika, Eni Enny Lestari Eva Meizara Puspita Dewi, Eva Meizara Fajarin, Rindang Febby Eka Putri Febrian Budi Pratama FELLY YULIAN FF, FELLY Fitri Rahmawati Fitriyani ZS, Syawalia Florensia Evindonta Bangun, Florensia Evindonta Gita Novian Hermana Gunawan, A. H. Guslihan Dasa Tjipta, Guslihan Dasa Hamzah Afandi Hanafiah A. Haninda Bharata Hariyati Purwaningsih Hasaruddin Hafid, Hasaruddin Indah Damayanti, Indah Iswanti, Nina Iwan Nurwantoro, Iwan Jayadinata, Asep Kurnia Juhamzah, Sulfiani Karim, Nina Karina Katibi, Ahmad Yakub Khairi, Husain Kholid, Rifki Rachman Kusuma, Ariya Eka Laksmi A. Lenap, Indria Puspitasari Lucia Maria Santoso, Lucia Maria M Coesamin M. Coesamin Mahfudho, Zahidatun Maskuroch Adesty Muhammad Safrudin Yafie Muhammad Yusuf Mulia, Septi Dianna Bunga Mustika, Lia Nanda, Evi Tirto Nasrun Nasrun Ningrum, Nia Widya Novianti, Elvita Lia Nurhanurawati Nurhanurawati Nurlaili Nurlaili Nurul Rohmah Nurvita Nurvita Nur’ainingsih, Dyah Parindra Kusriantoko Pentatito Gunowibowo Pratiwi, Ganjar Febriyani Pratiwi, Rafi Puji Rahayu Purnama Dewi Putri, Apriliani Qorri Ayuni Rani, wayan Widya Regina Lichteria Panjaitan, Regina Lichteria ria septiana Ridfah, Ahmad Ridfah, Ahmad Rini Asnawati Rini Rita T Marpaung Riyanto Riyanto Rizal Ramadhan Rizki Agustianto Robith Hudaya ROCHMAN R, ROCHMAN Rosalia Deviana Cahyaningrum Rusdi Setiono Sangaji, Darma Sapitri, Nonik Mega Sarlina Sarlina, Sarlina Silvana, Silvana Siti Laelatul Chasanah, Siti Laelatul Slamet Suprayogi Soraya, Rahayu Sri Hastuti Noer Sri Hastuti Noer Sri Setiyowati Sri Setyowati Sriyono Sriyono Sugeng Sutiarso Sukmawati, Fitriani Supriatmo Supriatmo, Supriatmo Syakir Mahid Tina Yunarti Titi Murniati Utami, Fithrina Yudha Utari Rezki Veronika Yulianti Wayan Rumite Wijayanti, Chusna Yuliana Yuliana Yulisa Yulisa Yuniarti, Tina Yunilda Yunilda YUSLI MARIADI Zuma Herdiyanti